Article
Multidisciplinary Sciences
Jeremy Di Domizio, Muhammet F. Gulen, Fanny Saidoune, Vivek V. Thacker, Ahmad Yatim, Kunal Sharma, Theo Nass, Emmanuella Guenova, Martin Schaller, Curdin Conrad, Christine Goepfert, Laurence de Leval, Christophe von Garnier, Sabina Berezowska, Anaelle Dubois, Michel Gilliet, Andrea Ablasser
Summary: This study reveals the mechanism behind aberrant type I interferon responses in COVID-19 through the cGAS-STING pathway and demonstrates its importance in severe cases. By using animal and lung-on-chip models, the study provides insights into host-directed therapeutic strategies for COVID-19.
Article
Multidisciplinary Sciences
Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U. Jung, Huaping Liang, Xiaozhen Liang
Summary: Type I interferons (IFNs) are the first line of defense against invading pathogens. This study identified a previously unknown protein, PINLYP, that interacts with TBK1 to induce the production of type I IFN. Loss of PINLYP impaired the activation of IRF3 and the production of IFN induced by various viruses and Toll-like receptor ligands. Mice lacking PINLYP were more susceptible to lethal virus infection, highlighting the importance of PINLYP in the host defense against viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Lauren E. Fritsch, Jing Ju, Erwin Kristobal Gudenschwager Basso, Eman Soliman, Swagatika Paul, Jiang Chen, Alexandra M. Kaloss, Elizabeth A. Kowalski, Taylor C. Tuhy, Rachana Deven Somaiya, Xia Wang, Irving Coy Allen, Michelle H. Theus, Alicia M. Pickrell
Summary: This study found that the cGAS-STING-mediated Type I interferon signaling pathway plays a critical role in neural tissue damage following TBI, and that mtDNA may be a possible trigger in this response.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Immunology
Zhe Ge, Shuzhe Ding
Summary: This paper summarizes the regulatory mechanism of the cGAS/STING signaling pathway and the immune escape mechanism of corresponding viruses, aiming to provide targeted immunotherapy ideas for specific viral infections in the future.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Mingyang Cheng, Makoye Mhozya Kanyema, Yu Sun, Wenhui Zhao, Yiyuan Lu, Junhong Wang, Xiaoxu Li, Chunwei Shi, Jianzhong Wang, Nan Wang, Wentao Yang, Yanlong Jiang, Haibin Huang, Guilian Yang, Yan Zeng, Chunfeng Wang, Xin Cao
Summary: African swine fever virus (ASFV) is a large double-stranded DNA virus that primarily infects porcine macrophages. The L83L gene in ASFV weakens the host immune system by blocking the cGAS-STING-mediated type I interferon signaling pathway through autophagy-lysosomal degradation of STING. This study provides insights into the evasion strategy used by ASFV and may contribute to the development of a vaccine against ASF.
JOURNAL OF VIROLOGY
(2023)
Article
Engineering, Environmental
Wencheng Xu, Luying Qiao, Zhifang Wang, Yanrong Qian, Lei Li, Qianqian Sun, Chunxia Li
Summary: HER2 can inhibit the immune activity of the cGAS-STING pathway, reducing its anti-tumor efficacy. Therefore, by designing a nanosystem and introducing the HER2-specific inhibitor Lapatinib, the immune therapeutic effect of the cGAS-STING pathway can be enhanced.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yutong Li, Juntao Bie, Chen Song, Yunfei Li, Tianzhuo Zhang, Haishuang Li, Long Zhao, Fuping You, Jianyuan Luo
Summary: This study reveals that SIRT2 negatively regulates the activation of cGAS through deacetylating G3BP1, indicating a potential antiviral strategy by modulating SIRT2 activity.
Review
Cell Biology
Yuting Yang, Yiming Huang, Zhenguo Zeng
Summary: Pathogens can produce conserved pathogen-associated molecular patterns (PAMPs) that are recognized by host pattern recognition receptors (PRRs). Recent studies have shown that cytoplasmic DNA receptors can specifically recognize exogenous DNA and activate interferon 1 (IFN1), which is a significant advancement in various research fields. The cGAS-STING signaling pathway is a critical natural immune pathway in cells and plays a crucial role in pathogen infection, tumors, and various autoimmune diseases in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Nanxin Liu, Xiaoxiao Pang, Hua Zhang, Ping Ji
Summary: The cGAS-STING pathway is crucial in protecting the host against viral infections and has also been found to play a role in response to bacterial infections. However, its functions in bacterial infections are more complex and diverse compared to viral infections, as the effects on the host vary depending on the bacterial species and infection mode.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei Si, Hua Liang, Jason Bugno, Qi Xu, Xingchen Ding, Kaiting Yang, Yanbin Fu, Ralph R. Weichselbaum, Xin Zhao, Liangliang Wang
Summary: Our study demonstrates that oral administration of live LGG enhances the antitumour activity of anti-PD-1 immunotherapy by increasing tumour-infiltrating DCs and T cells, and by shifting the gut microbial community towards enrichment in Lactobacillus murinus and Bacteroides uniformis. Mechanistically, LGG induces IFN-beta production via the cGAS/STING/TBK1/IRF7 axis in DCs, highlighting the potential of LGG as a combination agent with ICB for cancer therapies.
Article
Virology
Huifang Zhu, Rongzhao Zhang, Li Yi, Yan-Dong Tang, Chunfu Zheng
Summary: This study demonstrates that UNC93B1 acts as a crucial regulator of STING, attenuating its signaling pathway through autophagy-lysosome degradation, and provides novel insights into UNC93B1's function in antiviral innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Yang Du, Zhiqiang Hu, Yien Luo, Helen Y. Wang, Xiao Yu, Rong-Fu Wang
Summary: The DNA-sensing receptor cGAS and its downstream signaling adaptor STING play crucial roles in immune defense against infectious pathogens, and the interplay between the cGAS-STING pathway and pathogens provides insight into the development of pharmacological approaches for treating infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Lei Xu, Mengyuan Li, Yadong Yang, Chen Zhang, Zhen Xie, Jingjing Tang, Zhenkun Shi, Shukun Chen, Guangzhe Li, Yanchao Gu, Xiao Wang, Fuhua Zhang, Yao Wang, Xihui Shen
Summary: This study reveals the important role of the cytosolic surveillance pathway cGAS-STING in the activation of the type I interferon response during S. Typhimurium infection, in addition to the TLR4-dependent response. The study also highlights the significance of mtDNA release triggered by S. Typhimurium infection in the induction of type I interferon.
Review
Immunology
Ya Liu, Feifei Pu
Summary: This article reviews the important roles of the cGAS-STING signaling pathway in natural immunity, as well as the activation process and therapeutic drugs associated with autoimmune diseases. Studying these signaling pathways is of great significance for improving the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Behzad Hussain, Yufeng Xie, Uzma Jabeen, Defen Lu, Bo Yang, Changxin Wu, Guijun Shang
Summary: This review discusses the importance of the cGAS-cGAMP-STING pathway and the recent progress in understanding the activation mechanism of the STING protein. It also highlights the significance and potential applications of studying the STING activation mechanism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wen-Yu Cheng, Huai-Jie Jia, Xiao-Bing He, Guo-Hua Chen, Yuan Feng, Chun-Yan Wang, Xiao-Xia Wang, Zhi-Zhong Jing
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Medicine, Research & Experimental
Wenyu Cheng, Huaijie Jia, Xiaoxia Wang, Xiaobing He, Qiwang Jin, Jingxin Cao, Zhizhong Jing
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Wenyu Cheng, Guohua Chen, Huaijie Jia, Xiaobing He, Zhizhong Jing
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemical Research Methods
Wenyu Cheng, Xiaobing He, Huaijie Jia, Guohua Chen, Cong Wang, Jun Zhang, Zhizhong Jing
MOLECULAR AND CELLULAR PROBES
(2018)
Article
Environmental Sciences
Yuanyuan Li, Wenyu Cheng
Summary: This study assessed the knowledge and awareness of Human noroviruses (HuNoVs) infection among kindergarten parents. The survey revealed that most respondents had limited knowledge of HuNoV infection, including poor understanding of the incubation period, duration, and high-incidence seasons of the disease, as well as insufficient awareness of cleaning practices for contaminated areas. Factors associated with good knowledge of HuNoV infection were found to be level of education, occupation, history of infection, and HuNoV learning experience. The internet was the most commonly expected source of information on HuNoV among parents. These findings provide insights for developing effective strategies and educational materials for disease prevention and control.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)