Review
Microbiology
Yeshun Wu, Hongqing Xu, Xiaoming Tu, Zhenyan Gao
Summary: This article reviews the potential mechanisms of short-chain fatty acids in regulating blood pressure and their prospects as a target for preventing and treating hypertension.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Huimeng Liu, Meiyu Wang, Guangrui Chen, Huiyu Zhou, Jiahui Dong, Lei Yang, Tong Li, Zhiyun Meng, Ruolan Gu, Hui Gan, Zhuona Wu, Shuchen Liu, Yunbo Sun, Yong Yuan, Guifang Dou
Summary: This study explored the effects of radon exposure on gut microbiota and its metabolites (SCFAs) in BALB/c mice. The results showed that radon-exposed mice had slower body weight gain, decreased serum triglycerides and low-density lipoproteins, decreased diversity and altered abundance of gut microbiota. Radon exposure also affected the metabolic functions of gut microbiota, mainly carbohydrate, amino acid, and lipid metabolic pathways. The altered abundance of microbiota and resulting reduced levels of SCFAs may aggravate the damage caused by radon exposure.
Article
Chemistry, Applied
Lorena Calderon-Perez, Elisabet Llaurado, Judit Companys, Laura Pla-Paga, Anna Pedret, Laura Rubio, Maria Jose Gosalbes, Silvia Yuste, Rosa Sola, Rosa M. Valls
Summary: This study identified potential associations between dietary phenolic compounds (PCs), gut microbiota composition, and targeted faecal metabolites, highlighting the role of specific PCs as gut microbiome modulators in either the pathogenesis or prevention of hypertension in hypertensive (HT) and normotensive (NT) subjects.
Review
Nutrition & Dietetics
Peng Zhao, Suhong Zhao, Jinwei Tian, Xinxin Liu
Summary: This review primarily focuses on the relationship between the gut microbiota and its major metabolites, such as short-chain fatty acids (SCFAs), and heart failure (HF), aiming to explore effective treatments for HF by targeting SCFAs and improve patients' quality of life.
Review
Geriatrics & Gerontology
Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. They play a role in various physiological and pathological processes in the human body, including potential roles and mechanisms in neurodegenerative diseases such as Alzheimer's disease.
Article
Cardiac & Cardiovascular Systems
Ellen G. Avery, Hendrik Bartolomaeus, Andras Maifeld, Lajos Marko, Helge Wiig, Nicola Wilck, Stephan P. Rosshart, Sofia K. Forslund, Dominik N. Mueller
Summary: The pathogenesis of hypertension involves multiple factors including genetic, environmental, hormonal, hemodynamic, and inflammatory forces. There is increasing evidence that the gut microbiome plays a significant role in hypertension. Lifestyle factors such as dietary fiber consumption and fasting can impact hypertension through modulation of the microbiome.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Xiran Lou, Jinfang Xue, Ruifei Shao, Yan Yang, Deyuan Ning, Chunyan Mo, Fuping Wang, Guobing Chen
Summary: This study found significant differences in gut microbiota between sepsis patients and healthy individuals. Fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) were found to regulate the abundance of bacteria and improve survival rate and systemic inflammatory response in a mouse model of sepsis. These findings suggest that FMT and SCFAs may be a potential treatment for sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Huiqin Hou, Danfeng Chen, Kexin Zhang, Wanru Zhang, Tianyu Liu, Xin Dai, Bangmao Wang, Weilong Zhong, Hailong Cao
Summary: Colorectal cancer is the third most common cancer worldwide, and its development is closely related to changes in the gut microbiota and metabolites. Short-chain fatty acids play a crucial role in promoting intestinal health, inhibiting tumor development, and enhancing responses to chemotherapy and immunotherapy.
Article
Cell Biology
Kenneth J. O'Riordan, Michael K. Collins, Gerard M. Moloney, Emily G. Knox, Maria R. Aburto, Christine Fulling, Shane J. Morley, Gerard Clarke, Harriet Schellekens, John F. Cryan
Summary: The role of the intestinal microbiota in regulating gut-brain axis signaling has gained attention in recent years. Understanding the relationship between the gut microbiota, its metabolites, and the brain is crucial for developing new therapeutic approaches, including identifying psychobiotics. Current research focuses on the effects of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, on brain function, behavior, and physiology, and how these SCFAs enter the systemic circulation and can potentially impact the brain.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Velma T. E. Aho, Madelyn C. Houser, Pedro A. B. Pereira, Jianjun Chang, Knut Rudi, Lars Paulin, Vicki Hertzberg, Petri Auvinen, Malu G. Tansey, Filip Scheperjans
Summary: This study found that intestinal inflammatory responses and reductions in fecal SCFAs occur in Parkinson's disease (PD), are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels.
MOLECULAR NEURODEGENERATION
(2021)
Article
Food Science & Technology
Tong Sun, Jingyi Yang, Lili Lu
Summary: This study investigated the regulatory effects of Salidroside on gut microbiota disturbance in mice. The results showed that Salidroside can attenuate antibiotic-induced intestinal damage and reduce inflammation factors. Moreover, Salidroside promotes the recovery of gut microbiota, reshaping its structure and composition.
Article
Biotechnology & Applied Microbiology
Jing Zhang, Kun Zuo, Chen Fang, Xiandong Yin, Xiaoqing Liu, Jiuchang Zhong, Kuibao Li, Jing Li, Li Xu, Xinchun Yang
Summary: This study revealed dysbiotic gut microbiota in atrial fibrillation patients, coupled with disrupted SCFA-synthesis related genes, characterized by decreased abundances of KEGG orthologues, synthesis enzymatic genes, and harboring species.
Review
Cardiac & Cardiovascular Systems
Yang Guo, Xiaosu Li, Zhijian Wang, Bo Yu
Summary: This study revealed dysbiosis of gut microbiota in hypertension, characterized by decreased diversity, altered microbial structure, compositional changes in taxa, alterations in microbial function, and stronger microbial interactions. Depletion of short chain fatty acids (SCFAs) producers and over-growth of certain Proteobacteria and Bacteroidetes members were observed in the gut microbiota of hypertensive individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Preeti Dinesh Virwani, Gordon Qian, Matthew S. S. Hsu, Tommy K. K. T. S. Pijarnvanit, Carman Nga-Man Cheung, Yick Hin Chow, Lok Kan Tang, Yiu-Hei Tse, Jia-Wen Xian, Shirley Sau-Wing Lam, Crystal P. I. Lee, Chelsea C. W. Lo, Roxanna K. C. Liu, Tsi Lok Ho, Bak Yue Chow, Kin Sum Leung, Hing Wai Tsang, Emily K. K. Lo, Keith T. S. Tung, Sookja Kim Chung, Man-Fung Yuen, Suet Yi Leung, Patrick Ip, Ivan Fan-Ngai Hung, Jimmy Chun Yu Louie, Hani El-Nezami, Joshua Wing Kei Ho, Kui Kai Lau
Summary: Sex differences exist in the association between gut microbiota (GM) and hypertension. GM alterations are significantly associated with hypertension in women but not men. Additionally, propionic acid is independently associated with blood pressure in women. These findings highlight the importance of considering sex differences in studying and treating hypertension.
Review
Nutrition & Dietetics
Yang Jiao, Wenxing Li, Qianyi Zhang, Qianfeng Jiang
Summary: The relationship between gut microbiota (GM) and hypertension (HTN) is an active research area. Bibliometric tools were used to analyze critical articles in this field, providing an objective summary of the primary research directions, such as the relationship between GM and HTN, GM metabolites, high-salt diet, the developmental origins of health and disease, obstructive sleep apnea-induced hypertension, and antihypertensive peptide. The analysis aims to give researchers insights into hotspots and emerging trends in the field of GM and HTN for future research reference.
FRONTIERS IN NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Kymberleigh A. Romano, Ina Nemet, Prasenjit Prasad Saha, Arash Haghikia, Xinmin S. Li, Maradumane L. Mohan, Beth Lovano, Laurie Castel, Marco Witkowski, Jennifer A. Buffa, Yu Sun, Lin Li, Christopher M. Menge, Ilja Demuth, Maximilian Koenig, Elisabeth Steinhagen-Thiessen, Joseph A. DiDonato, Arjun Deb, Fredrik Baeckhed, W. H. Wilson Tang, Sathyamangla Venkata Naga Prasad, Ulf Landmesser, David R. Van Wagoner, Stanley L. Hazen
Summary: A study found that the gut microbiota-dependent metabolite PAGln is associated with the presence and severity of heart failure both clinically and mechanistically. The circulating levels of PAGln are dose-dependently correlated with heart failure presence and indices of severity. It was also found that PAGln directly promotes heart failure-related phenotypes. Modulating the gut microbiome and PAGln production may be a potential therapeutic target for heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Barbara J. H. Verhaar, Charlotte M. Mosterd, Didier Collard, Henrike Galenkamp, Majon Muller, Elena Rampanelli, Daniel H. van Raalte, Max Nieuwdorp, Bert-Jan H. van den Born
Summary: This study examined sex differences in plasma metabolite profiles associated with blood pressure and sympathicovagal balance, as well as associations between gut microbiota composition and blood pressure and heart rate variability. The results showed that plasma metabolite profiles are associated with blood pressure and heart rate variability in a sex-specific manner, and some of these metabolites are also associated with gut microbiota composition.
Article
Microbiology
Kazuyuki Kasahara, Robert L. Kerby, Qijun Zhang, Meenakshi Pradhan, Margarete Mehrabian, Aldons J. Lusis, Goran Bergstrom, Fredrik Backhed, Federico E. Rey
Summary: The study suggests that gut microbiota plays a role in the progression of inflammatory diseases such as atherosclerosis. It shows that certain gut bacteria can use uric acid as a carbon and energy source, and their catabolism of purines influences the levels of uric acid in the body. This highlights the importance of gut microbes in maintaining purine homeostasis and overall health.
CELL HOST & MICROBE
(2023)
Article
Biochemistry & Molecular Biology
Jayron J. Habibe, Ulrika Boulund, Maria P. Clemente-Olivo, Carlie J. M. de Vries, Etto C. Eringa, Max Nieuwdorp, Bart Ferwerda, Koos Zwinderman, Bert-Jan H. van den Born, Henrike Galenkamp, Daniel H. van Raalte
Summary: This study investigated the association between FHL2 genetic loci and type 2 diabetes and dyslipidemia using a large multiethnic cohort. The findings showed that specific lipid biomarkers were associated with FHL2 genetic polymorphisms, but only in the Ghanaian population. The study highlights the impact of ethnicity on lipid metabolism and diabetes risk, emphasizing the importance of multiethnic cohort studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Esther M. C. Vriend, Britt E. Wever, Thomas A. Bouwmeester, Charles Agyemang, Oscar H. Franco, Henrike Galenkamp, Eric P. Moll van Charante, Aeilko H. Zwinderman, Didier Collard, Bert-Jan H. van den Born
Summary: In this study, the researchers assessed ethnic differences in blood pressure over time in a multi-ethnic population in Amsterdam. They found that Ghanaian, Moroccan, and Turkish populations had a further increase in systolic blood pressure compared to the Dutch reference population. Differences in blood pressure were partially explained by differences in body mass index. The findings highlight the need for action to improve cardiovascular health management in multi-ethnic populations.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Karlijn A. C. Meeks, Amy R. Bentley, Charles Agyemang, Henrike Galenkamp, Bert-Jan H. van den Born, Nordin M. J. Hanssen, Ayo P. Doumatey, Adebowale A. Adeyemo, Charles N. Rotimi
Summary: West Africans and African Americans with West African ancestry have lower triglyceride levels compared to East Africans and Europeans. This study compared the association between triglycerides and cardiometabolic risk factors among different ancestry populations and found that the association was more consistent in West Africans and Europeans, while it varied in East Africans.
Article
Pharmacology & Pharmacy
Thei S. Steenvoorden, Robert E. van Duin, Janneke A. J. Rood, Hessel Peters-Sengers, Azam S. Nurmohamed, Frederike J. Bemelman, Liffert Vogt, Joost W. van Der Heijden
Summary: This study aimed to evaluate the safety and feasibility of peri-procedural alkaline phosphatase (AP) administration in living donor kidney transplantation. The results showed that the bRESCAP treatment group had lower expression of injury biomarkers in urine after 7 days, but there was no significant difference in kidney function after 1 year. Therefore, the bRESCAP treatment is feasible in kidney transplantation, might have a dampening effect on ischemia-reperfusion injury-induced renal inflammation, and raises no safety concerns.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Rosa D. Wouda, Martin Gritter, Micky Karsten, Erik H. A. Michels, Tamar M. Nieuweboer, A. H. Jan Danser, Martin H. de Borst, Ewout J. Hoorn, Joris I. Rotmans, Liffert Vogt
Summary: This study investigated whether intracellular uptake and potassium excretion after an acute oral potassium load depend on the accompanying anion and/or aldosterone. The results showed that potassium citrate has a greater effect on cellular potassium uptake and excretion compared to potassium chloride.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Sanne J. van der Veen, Mohamed el Sayed, Carla E. M. Hollak, Marion M. Brands, C. Khya S. Snelder, S. Matthijs Boekholdt, Liffert Vogt, Susan M. I. Goorden, Andre B. P. van Kuilenburg, Mirjam Langeveld
Summary: Fabry disease is a heterogeneous X-linked lysosomal storage disease with varying manifestations in the kidneys, heart, and brain even among patients of the same sex and classification. The study investigates the association between plasma lysoGb3 levels and disease manifestations in untreated patients with Fabry disease, and finds that higher levels of lysoGb3 are associated with disease progression in various organs.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pernille Baumann Toft, Hiroaki Yashiro, Derek M. Erion, Matthew Paul Gillum, Fredrik Backhed, Tulika Arora
Summary: Depletion of gut microbiota affects dietary protein metabolism and regulates GLP-1-mediated intestinal transit, playing an important role in host physiology.
Article
Multidisciplinary Sciences
Muhammad Tanweer Khan, Chinmay Dwibedi, Daniel Sundh, Meenakshi Pradhan, Jamie D. Kraft, Robert Caesar, Valentina Tremaroli, Mattias Lorentzon, Fredrik Backhed
Summary: This study successfully co-isolated Faecalibacterium prausnitzii and Desulfovibrio piger and identified their symbiotic relationship in growth and butyrate production. By adapting Faecalibacterium prausnitzii to tolerate oxygen exposure, researchers developed a next-generation probiotic formulation.
Article
Medicine, General & Internal
Charles F. Hayfron-Benjamin, Charles Agyemang, Bert-Jan H. van den Born, Albert G. B. Amoah, Kwesi Nyan Amissah-Arthur, Latif Musah, Benjamin Abaidoo, Pelagia Awula, Henry Wedoi Awuviri, Joseph Agyapong Abbey, Deladem A. Fummey, Joana N. Ackam, Gloria Odom Asante, Simone Hashimoto, Anke H. Maitland-van der Zee
Summary: This study found positive associations between pulmonary dysfunction and microvascular complications in patients with type 2 diabetes, with varying strengths depending on the specific circulation. Further research is needed to explore the mechanisms linking pulmonary dysfunction with microvascular complications in type 2 diabetes.
Article
Physiology
Didier Collard, Lennart van de Velde, Valerie E. Stegehuis, Ronak Delewi, Marcel A. M. Beijk, IJsbrand A. J. Zijlstra, Robbert J. de Winter, Liffert Vogt, Bert-Jan H. van den Born
Summary: Renal sympathetic innervation is crucial in regulating renal and systemic hemodynamics and serves as a target for pharmacological and catheter-based therapies. This study investigated the effect of static handgrip exercise on renal hemodynamics and intraglomerular pressure in humans. The findings suggest that measuring renal arterial pressure and flow velocity during handgrip exercise can help identify individuals with different levels of sympathetic control over renal perfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Martin O'Donnell, Salim Yusuf, Liffert Vogt, Andrew Mente, Franz H. Messerli
Summary: The article emphasizes the importance of reducing sodium intake and increasing potassium intake for the prevention of cardiovascular disease. Increased potassium intake can lower blood pressure and mitigate the hypertensive effects of excess sodium intake. Increasing potassium intake can be achieved through dietary intake of foods rich in potassium or salt substitution. Therefore, increasing potassium intake may be a more advantageous dietary strategy.
EUROPEAN HEART JOURNAL
(2023)
Article
Obstetrics & Gynecology
Veerle Kremer, Jetta J. Oppelaar, Theresa Gimbel, Susanne Koziarek, Wessel Ganzevoort, Marielle G. van Pampus, Bert-Jan Van den Born, Liffert Vogt, Christianne de Groot, Reinier A. Boon
Summary: This study found that NOVA2 regulates FLT1 splicing in endothelial cells, and the loss of NOVA2 results in impaired endothelial function, partially dependent on VEGF. A negative correlation between NOVA2 and sFLT1 was observed in pre-eclampsia patients.
REPRODUCTIVE SCIENCES
(2023)