期刊
CANCERS
卷 12, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cancers12030683
关键词
adoptive cell therapy of cancer; immunotherapy; TCR therapy; neoantigens; antigen-specific T cells; T cell-based therapy of solid tumours
类别
资金
- project International Centre for Cancer Vaccine Science within the International Research Agendas Programme of the Foundation for Polish Science - European Union under the European Regional Development Fund
In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.
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