A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

(2019) Matthew H. Foley et al.   PLoS Pathogens

Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure

(2019) Vasundhara Kain et al.   FASEB JOURNAL

Human Inflammaging

(2019) Tamàs Fülöp et al.   GERONTOLOGY

Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome–gut–brain axis modulation

(2019) Shokouh Ahmadi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

(2019) Mary Ellen Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

(2019) Ravinder Nagpal et al.   EBioMedicine

Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations

(2019) Kylie Kavanagh et al.   GeroScience

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice

(2019) Shaohua Wang et al.   GeroScience

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

(2018) Benthe van der Lugt et al.   Aging-US

Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome

(2018) Monica S. Spychala et al.   ANNALS OF NEUROLOGY

Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS

(2018) Stefania De Marco et al.   Evidence-based Complementary and Alternative Medicine

Benefaction of probiotics for human health: A review

(2018) Rout George Kerry et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

(2018) Lenan Zhuang et al.   Nature Communications

Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics

(2018) Janina A. Krumbeck et al.   Microbiome

Composition and richness of the serum microbiome differ by age and link to systemic inflammation

(2018) Thomas W. Buford et al.   GeroScience

Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease

(2018) Peter Hegyi et al.   PHYSIOLOGICAL REVIEWS

Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome

(2018) Ravinder Nagpal et al.   Scientific Reports

Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet

(2018) Ravinder Nagpal et al.   Journal of Diabetes Research

Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults ≥60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction

(2018) Haider J. Warraich et al.   Circulation-Heart Failure

Gut dysbiosis is associated with the reduced exercise capacity of elderly patients with hypertension

(2018) Yanbo Yu et al.   HYPERTENSION RESEARCH

Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces

(2018) Ravinder Nagpal et al.   Frontiers in Microbiology

Cross-Talk Between Gluten, Intestinal Microbiota and Intestinal Mucosa in Celiac Disease: Recent Advances and Basis of Autoimmunity

(2018) Atul Munish Chander et al.   Frontiers in Microbiology

Microbiome-Modulated Metabolites at the Interface of Host Immunity

(2017) Eran Blacher et al.   JOURNAL OF IMMUNOLOGY

Taking Obesity in Older Adults Seriously

(2017) Stephen B Kritchevsky   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of Gut Microbiota-Mediated Bile Acid Metabolism on the Solubilization Capacity of Bile Salt Micelles and Drug Solubility

(2017) Elaine F. Enright et al.   MOLECULAR PHARMACEUTICS

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

(2017) Thomas W. Buford   Microbiome

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

(2017) Michael DiMarzio et al.   PLoS One

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

(2017) Rizwan Ahmad et al.   Scientific Reports

Optimized Sample Handling Strategy for Metabolic Profiling of Human Feces

(2016) Jasmine Gratton et al.   ANALYTICAL CHEMISTRY

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy

(2016) Valéria Nunes-Souza et al.   Oxidative Medicine and Cellular Longevity

Impact of physical function impairment and multimorbidity on mortality among community-living older persons with sarcopaenia: results from theilSIRENTEprospective cohort study

(2016) Francesco Landi et al.   BMJ Open

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

(2016) Sara Gelino et al.   PLoS Genetics

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Taurine and skeletal muscle function

(2015) Lawrence L. Spriet et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Probiotics as Potential Antioxidants: A Systematic Review

(2015) Vijendra Mishra et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Association of Physical Activity History With Physical Function and Mortality in Old Age

(2015) Sari Stenholm et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Butyrate benefits the intestinal barrier

(2015) Annalisa M. VanHook   Science Signaling

Butyrate benefits the intestinal barrier

(2015) Annalisa M. VanHook   Science Signaling

Obesity in the elderly: More complicated than you think

(2014) D. C. CETIN et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Label-Free Imaging of Lipid Depositions in C. elegans Using Third-Harmonic Generation Microscopy

(2014) George J. Tserevelakis et al.   PLoS One

Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice

(2014) Takashi Ito et al.   PLoS One

Economic and social implications of aging societies

(2014) S. Harper   SCIENCE

Methods to Assess Subcellular Compartments of Muscle in C. elegans

(2014) Christopher J. Gaffney et al.   Jove-Journal of Visualized Experiments

Probiotics, prebiotics, and the host microbiome: the science of translation

(2013) Bryon Petschow et al.   Annals of the New York Academy of Sciences

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

(2013) Hariom Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probiotics and prebiotics and health in ageing populations

(2013) Sylvia H. Duncan et al.   MATURITAS

Probiotics, their health benefits and applications for developing healthier foods: a review

(2012) Ravinder Nagpal et al.   FEMS MICROBIOLOGY LETTERS

Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms

(2012) J Gregory Caporaso et al.   ISME Journal

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

(2011) Gregory M. Solis et al.   Jove-Journal of Visualized Experiments

Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells

(2010) W. Cui et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Cancer-preventing attributes of probiotics: an update

(2010) Manoj Kumar et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Simultaneous quantification of glycine- and taurine-conjugated bile acids, total bile acids, and choline-containing phospholipids in human bile using 1H NMR spectroscopy

(2010) Omkar B. Ijare et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Taurine supplementation increases skeletal muscle force production and protects muscle function during and after high-frequency in vitro stimulation

(2009) Craig A. Goodman et al.   JOURNAL OF APPLIED PHYSIOLOGY

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Intestinal bile acid physiology and pathophysiology

(2008) Olga Martínez-Augustin et al.   WORLD JOURNAL OF GASTROENTEROLOGY