标题
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase
作者
关键词
-
出版物
Nature Microbiology
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-07-14
DOI
10.1038/s41564-020-0752-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation
- (2020) Ryan Abdella et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity
- (2019) Theresa Enkirch et al. Frontiers in Immunology
- Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses
- (2019) Ogino et al. Viruses-Basel
- Small molecule grp94 inhibitors block dengue and Zika virus replication
- (2019) Hussin A. Rothan et al. ANTIVIRAL RESEARCH
- Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
- (2019) Mart Toots et al. Science Translational Medicine
- A Phase 2b Randomized Controlled Trial of Presatovir, an Oral RSV Fusion Inhibitor, for the Treatment of Respiratory Syncytial Virus (RSV) in Lung Transplant (LT) Recipients
- (2018) J. Gottlieb et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation
- (2018) Sho Iketani et al. mBio
- Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
- (2018) Paul C. Jordan et al. PLoS Pathogens
- Biology must develop herd immunity against bad-actor molecules
- (2018) Richard K. Plemper et al. PLoS Pathogens
- Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex
- (2018) Robert M Cox et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- State of the Art in Respiratory Syncytial Virus Drug Discovery and Development
- (2018) G. Stuart Cockerill et al. JOURNAL OF MEDICINAL CHEMISTRY
- Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine
- (2018) Hao Chi et al. NATURE BIOTECHNOLOGY
- Dynamics of Sendai Virus Spread, Clearance, and Immunotherapeutic Efficacy after Hematopoietic Cell Transplant Imaged Noninvasively in Mice
- (2017) Heba H. Mostafa et al. JOURNAL OF VIROLOGY
- A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro
- (2017) Kinga Balogh Sivars et al. TOXICOLOGICAL SCIENCES
- RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V
- (2017) Molly R. Braun et al. PLoS Pathogens
- Efficient and Robust Paramyxoviridae Reverse Genetics Systems
- (2017) Shannon M. Beaty et al. mSphere
- New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase
- (2016) Rachel Fearns et al. ANTIVIRAL RESEARCH
- Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen
- (2016) Jeremy R. Duvall et al. ANTIVIRAL RESEARCH
- Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier of drug resistance
- (2016) Chunlong Ma et al. ANTIVIRAL RESEARCH
- Rapid Metagenomic Next-Generation Sequencing during an Investigation of Hospital-Acquired Human Parainfluenza Virus 3 Infections
- (2016) Alexander L. Greninger et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Paramyxovirus Infection: Mortality and Morbidity in a Pediatric Intensive Care Unit
- (2016) Alice S. W. Tong et al. JOURNAL OF TROPICAL PEDIATRICS
- The Immune Response in Measles: Virus Control, Clearance and Protective Immunity
- (2016) Diane Griffin Viruses-Basel
- Relationships among Dissemination of Primary Parainfluenza Virus Infection in the Respiratory Tract, Mucosal and Peripheral Immune Responses, and Protection from Reinfection: a Noninvasive Bioluminescence-Imaging Study
- (2015) Crystal W. Burke et al. JOURNAL OF VIROLOGY
- Characterization of a Respiratory Syncytial Virus L Protein Inhibitor
- (2014) Choi-Lai Tiong-Yip et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discontinued drugs in 2012 – 2013: hepatitis C virus infection
- (2014) Ivan Gentile et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Sendai Virus Pathogenesis in Mice Is Prevented by Ifit2 and Exacerbated by Interferon
- (2014) J. L. Wetzel et al. JOURNAL OF VIROLOGY
- An Outbreak of Measles in an Undervaccinated Community
- (2014) P. Gahr et al. PEDIATRICS
- An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model
- (2014) S. A. Krumm et al. Science Translational Medicine
- Estimates of Parainfluenza Virus-Associated Hospitalizations and Cost Among Children Aged Less Than 5 Years in the United States, 1998–2010
- (2014) Glen R. Abedi et al. Journal of the Pediatric Infectious Diseases Society
- Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal PhenotypeIn Vivo
- (2013) Catherine Spickler et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
- (2012) D. C. Koboldt et al. GENOME RESEARCH
- Independent Structural Domains inParamyxovirusPolymerase Protein
- (2012) Melanie Dochow et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ethical Issues in Neonatal and Pediatric Clinical Trials
- (2012) Naomi Laventhal et al. PEDIATRIC CLINICS OF NORTH AMERICA
- Pathogenesis of acute respiratory illness caused by human parainfluenza viruses
- (2012) Henrick Schomacker et al. Current Opinion in Virology
- The Respiratory Syncytial Virus Polymerase Has Multiple RNA Synthesis Activities at the Promoter
- (2012) Sarah L. Noton et al. PLoS Pathogens
- Mechanism of Fusion Triggering by Human Parainfluenza Virus Type III
- (2011) Matteo Porotto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5
- (2011) Takemasa Sakaguchi et al. MICROBIOLOGY AND IMMUNOLOGY
- Potent Host-Directed Small-Molecule Inhibitors of Myxovirus RNA-Dependent RNA-Polymerases
- (2011) Stefanie A. Krumm et al. PLoS One
- Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus
- (2010) John P. DeVincenzo et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
- (2010) K. Wang et al. NUCLEIC ACIDS RESEARCH
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues
- (2009) Nathaniel A Brown EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors‡
- (2009) Jesus M. Ontoria et al. JOURNAL OF MEDICINAL CHEMISTRY
- Human Parainfluenza Virus Infection of the Airway Epithelium: Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein Activation and Modulates Infectivity
- (2009) L. M. Palermo et al. JOURNAL OF VIROLOGY
- Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
- (2008) Frank Ruebsam et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now