A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro

Establishment and characterization of an in vitro human small airway model (SmallAir™)

(2017) Song Huang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

(2017) Louise V Wain et al.   NATURE GENETICS

Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution

(2016) Jose Zavala et al.   INHALATION TOXICOLOGY

Toxicity assessment of aggregated/agglomerated cerium oxide nanoparticles in an in vitro 3D airway model: The influence of mucociliary clearance

(2015) C. Frieke Kuper et al.   TOXICOLOGY IN VITRO

Toxicological perspectives of inhaled therapeutics and nanoparticles

(2014) Amanda J Hayes et al.   Expert Opinion on Drug Metabolism & Toxicology

A 26-Week Toxicity Assessment of AIR001 (Sodium Nitrite) by Inhalation Exposure in Rats and by Intravenous Administration in Dogs

(2014) Jeffrey Tepper et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Nasal Epithelial Cells Can Act as a Physiological Surrogate for Paediatric Asthma Studies

(2014) Surendran Thavagnanam et al.   PLoS One

Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

(2013) Anita R. Iskandar et al.   Biomed Research International

Potential of in vitro reconstituted 3D human airway epithelia (MucilAir™) to assess respiratory sensitizers

(2012) Song Huang et al.   TOXICOLOGY IN VITRO

The preclinical toxicology of salmeterol hydroxynaphthoate

(2010) K. Owen et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Modulation of sensory nerve function and the cough reflex: Understanding disease pathogenesis

(2009) Julie Nasra et al.   PHARMACOLOGY & THERAPEUTICS

Nasal Epithelial Cells as Surrogates for Bronchial Epithelial Cells in Airway Inflammation Studies

(2008) Catherine M. McDougall et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

In vitromodels of the human epithelial airway barrier to study the toxic potential of particulate matter

(2008) Barbara Rothen-Rutishauser et al.   Expert Opinion on Drug Metabolism & Toxicology

Prevalence, pathogenesis, and causes of chronic cough

(2008) Kian Fan Chung et al.   LANCET

An in vitro approach to assess the toxicity of inhaled tobacco smoke components: Nicotine, cadmium, formaldehyde and urethane

(2007) Dominique Balharry et al.   TOXICOLOGY