Hypertriglyceridemia and Atherosclerosis: Using Human Research to Guide Mechanistic Studies in Animal Models

The polygenic nature of mild-to-moderate hypertriglyceridemia

(2020) Jacqueline S. Dron et al.   Journal of Clinical Lipidology

GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells

(2020) Xia Meng et al.   JOURNAL OF LIPID RESEARCH

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

(2020) Kristian K. Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual apolipoprotein C-II mimetic–apolipoprotein C-III antagonist peptide lowers plasma triglycerides

(2020) Anna Wolska et al.   Science Translational Medicine

Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease

(2020) Alan Chait et al.   DIABETES

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

(2019) Frode Norheim et al.   Cell Metabolism

Knockout rat models mimicking human atherosclerosis created by Cpf1-mediated gene targeting

(2019) Jong Geol Lee et al.   Scientific Reports

Lipoprotein lipase is active as a monomer

(2019) Anne P. Beigneux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or apoC3 RNA interference

(2019) Andrew A. Butler et al.   JOURNAL OF LIPID RESEARCH

Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

(2019) Brian A. Ference et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice

(2019) Xuejing Liu et al.   ATHEROSCLEROSIS

Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment

(2019) Kota Suzuki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD

(2019) Marja-Riitta Taskinen et al.   Current Atherosclerosis Reports

ApoC-III ASO Promotes Tissue LPL Activity in Absence of ApoE-Mediated TRL Clearance

(2019) Bastian Ramms et al.   JOURNAL OF LIPID RESEARCH

Structure of lipoprotein lipase in complex with GPIHBP1

(2019) Rishi Arora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

(2019) Stephen G. Young et al.   Cell Metabolism

Effect Of Lipoprotein Lipase (Lpl) Deletion On Atherosclerosis Regression

(2019) D. Basu et al.   ATHEROSCLEROSIS

Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes

(2019) Jenny E. Kanter et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduction in First and Total Ischemic Events With Icosapent Ethyl Across Baseline Triglyceride Tertiles

(2019) Deepak L. Bhatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome

(2019) Joseph L. Witztum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Investigational drugs in development for hypertriglyceridemia: a coming-of-age story

(2019) David Rhainds et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Familial chylomicronemia syndrome: an under‐recognized cause of severe hypertriglyceridaemia

(2019) A. Baass et al.   JOURNAL OF INTERNAL MEDICINE

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

(2019) Stephen Zewinger et al.   NATURE IMMUNOLOGY

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats

(2018) Yongliang Zhao et al.   ATHEROSCLEROSIS

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3

(2018) Alexandra C. Chadwick et al.   CIRCULATION

It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm

(2018) Valentina Shakhnovich   CTS-Clinical and Translational Science

Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia

(2018) Yoichi Kawashima et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics

(2018) Ida Rune et al.   Scientific Reports

Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice

(2018) Han Yingchun et al.   Lipids in Health and Disease

The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk

(2018) Pratik B Sandesara et al.   ENDOCRINE REVIEWS

Severe hypertriglyceridemia is primarily polygenic

(2018) Jacqueline S. Dron et al.   Journal of Clinical Lipidology

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

ANGPTL4 variants and their haplotypes are associated with serum lipid levels, the risk of coronary artery disease and ischemic stroke and atorvastatin cholesterol-lowering responses

(2018) Qian Yang et al.   Nutrition & Metabolism

Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis

(2018) Gabriel Birrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field

(2017) Peter J Havel et al.   ILAR JOURNAL

A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis

(2017) Masako Ueda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL

(2017) Mikael Larsson et al.   JOURNAL OF LIPID RESEARCH

Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

(2017) Raimund Pechlaner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

(2017) Nathan O. Stitziel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

(2017) Danish Saleheen et al.   NATURE

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

(2017) Sumeet A Khetarpal et al.   NATURE MEDICINE

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

(2017) Anne P. Beigneux et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

(2017) Mark J. Graham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

(2017) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

(2017) Xun Chi et al.   Molecular Metabolism

Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature

(2017) Kiran Joglekar et al.   Therapeutic Advances in Endocrinology and Metabolism

Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1

(2017) Keyang Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis inLdlr−/−MiceHighlights

(2016) Jong-Gil Park et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

(2016) Philip L.S.M. Gordts et al.   JOURNAL OF CLINICAL INVESTIGATION

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

(2016) Simon Mysling et al.   eLife

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

(2016) Simon Mysling et al.   eLife

Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries

(2015) Shujie Wei et al.   ATHEROSCLEROSIS

Vascular risk factors, vascular disease, lipids and lipid targets in patients with familial dysbetalipoproteinemia: A European cross-sectional study

(2015) C. Koopal et al.   ATHEROSCLEROSIS

Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII

(2015) Haibo Li et al.   CARDIOVASCULAR RESEARCH

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

(2015) C. Liu et al.   Disease Models & Mechanisms

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

(2015) Viktoria Gusarova et al.   JOURNAL OF LIPID RESEARCH

Chylomicronaemia—current diagnosis and future therapies

(2015) Amanda J. Brahm et al.   Nature Reviews Endocrinology

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

(2015) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits

(2015) Bo Ning et al.   Nutrition & Metabolism

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

(2015) Brian J. Bennett et al.   PLoS Genetics

Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

(2015) Suvi E. Heinonen et al.   Journal of Diabetes Research

The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries

(2014) Chris N. Goulbourne et al.   Cell Metabolism

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

(2014) João Paulo G. Camporez et al.   JOURNAL OF LIPID RESEARCH

Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

(2014) Robert S. Rosenson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Occlusal disharmony accelerates the initiation of atherosclerosis in apoE knockout rats

(2014) Daisuke Ekuni et al.   Lipids in Health and Disease

Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

(2014) Anders Berg Jørgensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting APOC3 in the Familial Chylomicronemia Syndrome

(2014) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Hypertriglyceridemia in the Development of Atherosclerosis and Endothelial Dysfunction

(2014) Saki Matsumoto et al.   Nutrients

Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

(2013) Mark J. Graham et al.   CIRCULATION RESEARCH

Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity

(2013) Manabu Takahashi et al.   JOURNAL OF LIPID RESEARCH

Hypertriglyceridemia

(2013) Amanda Brahm et al.   Nutrients

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

(2013) Robert A Hegele et al.   Lancet Diabetes & Endocrinology

Transgenic Expression and Genetic Variation of Lmf1 Affect LPL Activity in Mice and Humans

(2012) Maryam Hosseini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Triglyceride: One molecule at the center of health and disease

(2012) Ira J. Goldberg   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells

(2012) Brandon S. J. Davies et al.   JOURNAL OF LIPID RESEARCH

Triglycerides and Cardiovascular Disease

(2011) Michael Miller et al.   CIRCULATION

Excess of Rare Variants in Non–Genome-Wide Association Study Candidate Genes in Patients With Hypertriglyceridemia

(2011) Christopher T. Johansen et al.   Circulation-Cardiovascular Genetics

Fructose-Fed Rhesus Monkeys: A Nonhuman Primate Model of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes

(2011) Andrew A. Bremer et al.   CTS-Clinical and Translational Science

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

(2011) M. John Chapman et al.   EUROPEAN HEART JOURNAL

Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII

(2011) Jingyuan Wei et al.   FEBS Journal

Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice

(2011) Joshua E. Basford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

(2011) Jung Hoon Lee et al.   NATURE MEDICINE

Comparative studies of glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1: evidence for a eutherian mammalian origin for the GPIHBP1 gene from an LY6-like gene

(2011) Roger S. Holmes et al.   3 Biotech

GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

(2010) Brandon S.J. Davies et al.   Cell Metabolism

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

(2010) Laeticia Lichtenstein et al.   Cell Metabolism

A high-resolution association mapping panel for the dissection of complex traits in mice

(2010) B. J. Bennett et al.   GENOME RESEARCH

Chylomicron- and VLDL-derived Lipids Enter the Heart through Different Pathways

(2010) Kalyani G. Bharadwaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chylomicronemia Elicits Atherosclerosis in Mice—Brief Report

(2009) Michael M. Weinstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NovelLMF1Nonsense Mutation in a Patient with Severe Hypertriglyceridemia

(2009) Angelo B. Cefalù et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A quantitative assay measuring the function of lipase maturation factor 1

(2009) Fen Yin et al.   JOURNAL OF LIPID RESEARCH

In Vivo Arterial Lipoprotein Lipase Expression Augments Inflammatory Responses and Impairs Vascular Dilatation

(2008) Mayumi Takahashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

(2008) Hironori Adachi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atheroprotective Effect of Human Apolipoprotein A5 in a Mouse Model of Mixed Dyslipidemia

(2008) Roxane M. Mansouri et al.   CIRCULATION RESEARCH

Apoprotein A-V: An important regulator of triglyceride metabolism

(2008) M. Kluger et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall

(2008) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH

Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice

(2008) F. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection

(2008) T. I. Pollin et al.   SCIENCE

Spontaneous Atherosclerosis in Aged Lipoprotein Lipase–Deficient Mice With Severe Hypertriglyceridemia on a Normal Chow Diet

(2007) Xiaohong Zhang et al.   CIRCULATION RESEARCH