NEK7 Coordinates Rapid Neuroinflammation After Subarachnoid Hemorrhage in Mice

MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats

(2019) Yujie Luo et al.   BRAIN RESEARCH BULLETIN

Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates

(2018) Dario Valdinocci et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation

(2018) Gabsik Yang et al.   RHEUMATOLOGY

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

(2018) Francisco Freixo et al.   Nature Communications

Nexilin Regulates Oligodendrocyte Progenitor Cell Migration and Remyelination and Is Negatively Regulated by Protease-Activated Receptor 1/Ras-Proximate-1 Signaling Following Subarachnoid Hemorrhage

(2018) Qiang Li et al.   Frontiers in Neurology

The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury

(2018) Kai-Ying Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons

(2018) Antonio Jesús Hinojosa et al.   Cell Reports

Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases

(2018) Bo-Zong Shao et al.   Frontiers in Molecular Neuroscience

Cyclosporine A alleviated matrix metalloproteinase 9 associated blood-brain barrier disruption after subarachnoid hemorrhage in mice

(2017) Pengyu Pan et al.   NEUROSCIENCE LETTERS

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

(2017) Yi Zhang et al.   Cell Death & Disease

Serum potassium and sodium levels after subarachnoid haemorrhage

(2016) Inga Chen et al.   BRITISH JOURNAL OF NEUROSURGERY

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

Artesunate Protected Blood–Brain Barrier via Sphingosine 1 Phosphate Receptor 1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats

(2016) Shilun Zuo et al.   MOLECULAR NEUROBIOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

(2016) Manohar Salla et al.   ACS Medicinal Chemistry Letters

Hemoglobin induced NO/cGMP suppression Deteriorate Microcirculation via Pericyte Phenotype Transformation after Subarachnoid Hemorrhage in Rats

(2016) Qiang Li et al.   Scientific Reports

Microglia inflict delayed brain injury after subarachnoid hemorrhage

(2015) Ulf C. Schneider et al.   ACTA NEUROPATHOLOGICA

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Human Nek7-interactor RGS2 is required for mitotic spindle organization

(2015) Edmarcia Elisa de Souza et al.   CELL CYCLE

Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats

(2015) Bo Li et al.   CRITICAL CARE MEDICINE

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain

(2015) Nan Yan et al.   MOLECULAR NEUROBIOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Controversies and evolving new mechanisms in subarachnoid hemorrhage

(2013) Sheng Chen et al.   PROGRESS IN NEUROBIOLOGY

Role of HCN Channels in Neuronal Hyperexcitability after Subarachnoid Hemorrhage in Rats

(2012) B. Li et al.   JOURNAL OF NEUROSCIENCE

The vascular neural network—a new paradigm in stroke pathophysiology

(2012) John H. Zhang et al.   Nature Reviews Neurology

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

(2010) Alexander T Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

(2009) S. Jha et al.   JOURNAL OF IMMUNOLOGY

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY