A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease

(2020) Pascaline Aimé et al.   NEUROBIOLOGY OF DISEASE

Insights into human genetic variation and population history from 929 diverse genomes

(2020) Anders Bergström et al.   SCIENCE

Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer

(2019) Isidre Felip et al.   GYNECOLOGIC ONCOLOGY

Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia

(2019) Katerina Harvati et al.   NATURE

Human-specific tandem repeat expansion and differential gene expression during primate evolution

(2019) Arvis Sulovari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP–ATF response elements in the Fgf21 promoter

(2018) Tiit Örd et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Susceptibility of brain atrophy toTRIB3in Alzheimer’s disease, evidence from functional prioritization in imaging genetics

(2018) Marco Lorenzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The earliest modern humans outside Africa

(2018) Israel Hershkovitz et al.   SCIENCE

A Census of Tandemly Repeated Polymorphic Loci in Genic Regions Through the Comparative Integration of Human Genome Assemblies

(2018) Loredana M. Genovese et al.   Frontiers in Genetics

Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia

(2018) Janet H.T. Song et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Disease status affects the association between rs4813620 and the expression of Alzheimer’s disease susceptibility geneTRIB3

(2018) Guiyou Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

(2017) Mario Mitt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Governing roles for Trib3 pseudokinase during stress erythropoiesis

(2017) Arvind Dev et al.   EXPERIMENTAL HEMATOLOGY

A high-coverage Neandertal genome from Vindija Cave in Croatia

(2017) Kay Prüfer et al.   SCIENCE

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis

(2017) Lee Butcher et al.   Scientific Reports

C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis

(2017) Kaido Lepik et al.   PLoS Computational Biology

TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1

(2016) Daima Örd et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal Death

(2016) Suraiya Saleem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor

(2015) Tiit Örd et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase

(2015) T. Erazo et al.   CLINICAL CANCER RESEARCH

Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models

(2015) P. Aime et al.   JOURNAL OF NEUROSCIENCE

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

(2015) Christopher J. Huggins et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic variation and the de novo assembly of human genomes

(2015) Mark J. P. Chaisson et al.   NATURE REVIEWS GENETICS

GenomeTester4: a toolkit for performing basic set operations - union, intersection and complement on k-mer lists

(2015) Lauris Kaplinski et al.   GigaScience

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

(2014) M Salazar et al.   CELL DEATH AND DIFFERENTIATION

Tribbles Homolog 3 Attenuates Mammalian Target of Rapamycin Complex-2 Signaling and Inflammation in the Diabetic Kidney

(2014) E. Borsting et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Replication of linkage at chromosome 20p13 and identification of suggestive sex-differential risk loci for autism spectrum disorder

(2014) Donna M Werling et al.   Molecular Autism

The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action

(2013) María Salazar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons

(2013) N Zareen et al.   CELL DEATH AND DIFFERENTIATION

Gene-Centric Analysis Identifies Variants Associated With Interleukin-6 Levels and Shared Pathways With Other Inflammation Markers

(2013) Tina Shah et al.   Circulation-Cardiovascular Genetics

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGF  pathways as fundamental Notch regulators in breast cancer

(2013) J. Izrailit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A High-Coverage Genome Sequence from an Archaic Denisovan Individual

(2012) M. Meyer et al.   SCIENCE

A Molecular Phylogeny of Living Primates

(2011) Polina Perelman et al.   PLoS Genetics

Whole genome association scan for genetic polymorphisms influencing information processing speed

(2010) Michelle Luciano et al.   BIOLOGICAL PSYCHOLOGY

TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion

(2010) S. Prudente et al.   DIABETOLOGIA

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells

(2010) Chong Wee Liew et al.   JOURNAL OF CLINICAL INVESTIGATION

Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway

(2010) Valérie Carraro et al.   PLoS One

A Draft Sequence of the Neandertal Genome

(2010) R. E. Green et al.   SCIENCE

Human TRB3 is upregulated in stressed cells by the induction of translationally efficient mRNA containing a truncated 5′-UTR

(2009) Tiit Örd et al.   GENE

Detection of nonneutral substitution rates on mammalian phylogenies

(2009) K. S. Pollard et al.   GENOME RESEARCH

Elevated ATF4 Expression, in the Absence of Other Signals, Is Sufficient for Transcriptional Induction via CCAAT Enhancer-binding Protein-activating Transcription Factor Response Elements

(2009) Jixiu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Control of Skeletogenesis

(2008) Gerard Karsenty   Annual Review of Genomics and Human Genetics