The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

(2016) Madhvi Menon et al.   IMMUNITY

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus

(2016) Malte A. Kluger et al.   KIDNEY INTERNATIONAL

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

MicroRNA: master controllers of intracellular signaling pathways

(2015) Pak-Yin Lui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice

(2015) Lindsay J. Edwards et al.   CLINICAL IMMUNOLOGY

Transcriptional enhancers: functional insights and role in human disease

(2015) Irene Miguel-Escalada et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases

(2015) Itay Raphael et al.   CYTOKINE

T follicular helper cells, T follicular regulatory cells and autoimmunity

(2015) Yangyang Zhu et al.   INTERNATIONAL IMMUNOLOGY

Immunogenetics of systemic lupus erythematosus: A comprehensive review

(2015) Yogita Ghodke-Puranik et al.   JOURNAL OF AUTOIMMUNITY

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

(2015) Vaishali R. Moulton et al.   JOURNAL OF CLINICAL INVESTIGATION

Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs

(2015) Ali A. Abdul-Sater et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation

(2015) Guangjin Li et al.   JOURNAL OF IMMUNOLOGY

Super-enhancers delineate disease-associated regulatory nodes in T cells

(2015) Golnaz Vahedi et al.   NATURE

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intersection of mTOR and STAT signaling in immunity

(2015) Diana Saleiro et al.   TRENDS IN IMMUNOLOGY

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Super-enhancers: Asset management in immune cell genomes

(2015) Steven Witte et al.   TRENDS IN IMMUNOLOGY

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus

(2015) Tue Kruse Rasmussen et al.   ARTHRITIS RESEARCH & THERAPY

Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome

(2015) Yu Gyoung Tak et al.   Epigenetics & Chromatin

Development of Th17-associated interstitial kidney inflammation in lupus-prone mice lacking the gene encoding STAT-1

(2015) Gloria Yiu et al.   Arthritis & Rheumatology

Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes

(2015) Marija Holcar et al.   Journal of Immunology Research

Transcriptional Enhancers in the Regulation of T Cell Differentiation

(2015) Michelle L. T. Nguyen et al.   Frontiers in Immunology

Animal Models of Interferon Signature Positive Lupus

(2015) Haoyang Zhuang et al.   Frontiers in Immunology

The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

(2015) Amalia Lamana et al.   PLoS One

Association of signaling transducers and activators of transcription 1 and systemic lupus erythematosus

(2014) Yan Liang et al.   AUTOIMMUNITY

Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3− cells versus regulatory T cells: A whole blood perspective

(2014) Guillaume Dupont et al.   CYTOKINE

Innate immune regulation by STAT-mediated transcriptional mechanisms

(2014) Haiyan S. Li et al.   IMMUNOLOGICAL REVIEWS

Transcriptional and epigenetic regulation of T-helper lineage specification

(2014) Subhash K. Tripathi et al.   IMMUNOLOGICAL REVIEWS

Loss of STAT3 in CD4 + T Cells Prevents Development of Experimental Autoimmune Diseases

(2014) Xuebin Liu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-  in Lupus Patients In Vivo

(2014) S. N. Kariuki et al.   JOURNAL OF IMMUNOLOGY

Autocrine Regulation of IL-21 Production in Human T Lymphocytes

(2014) F. Caprioli et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Jak/STAT Signaling in Immunity and Disease

(2014) Alejandro V. Villarino et al.   JOURNAL OF IMMUNOLOGY

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Stat3 promotes IL-10 expression in lupus T cells throughtrans-activation and chromatin remodeling

(2014) Christian M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus

(2014) Paul R Dominguez-Gutierrez et al.   ARTHRITIS RESEARCH & THERAPY

CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis?

(2014) Michael Bonelli et al.   ARTHRITIS RESEARCH & THERAPY

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage

(2014) Leen Moens et al.   Frontiers in Immunology

The Percentage of FoxP3+Helios+ Treg Cells Correlates Positively With Disease Activity in Systemic Lupus Erythematosus

(2013) Amit Golding et al.   ARTHRITIS AND RHEUMATISM

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells

(2013) Jennifer A. Jenks et al.   CLINICAL IMMUNOLOGY

Human T follicular helper (Tfh) cells and disease

(2013) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

Control of TFH cell numbers: why and how?

(2013) Alvin Pratama et al.   IMMUNOLOGY AND CELL BIOLOGY

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome

(2013) Gulbu Uzel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Positive Correlation of STAT1 and miR-146a with Anemia in Patients with Systemic Lupus Erythematosus

(2013) Paul R. Dominguez-Gutierrez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

(2013) Elissa K. Deenick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: The Pathogenicity of IFN- -Producing Th17 Cells Is Independent of T-bet

(2013) R. Duhen et al.   JOURNAL OF IMMUNOLOGY

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

(2013) Karin Bolin et al.   PLoS One

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

(2013) S. C. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT2 deficiency and susceptibility to viral illness in humans

(2013) S. Hambleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Recent insights into the genetic basis of systemic lupus erythematosus

(2012) Ornella Josephine Rullo et al.   ANNALS OF THE RHEUMATIC DISEASES

Foxp3+Helios+regulatory T cells are expanded in active systemic lupus erythematosus

(2012) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

STATs Shape the Active Enhancer Landscape of T Cell Populations

(2012) Golnaz Vahedi et al.   CELL

Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis

(2012) M-C. Lu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background

(2012) Maverick Lau et al.   JOURNAL OF AUTOIMMUNITY

Role of Cytokines in Systemic Lupus Erythematosus: Recent Progress from GWAS and Sequencing

(2012) John J. Connolly et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Myeloid Dendritic Cells from B6.NZM Sle1/Sle2/Sle3 Lupus-Prone Mice Express an IFN Signature That Precedes Disease Onset

(2012) U. Sriram et al.   JOURNAL OF IMMUNOLOGY

Anti-IFN- /  Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice

(2012) R. Baccala et al.   JOURNAL OF IMMUNOLOGY

Constitutive Phosphorylation of Interferon Receptor A-Associated Signaling Proteins in Systemic Lupus Erythematosus

(2012) Gabriela Ramírez-Vélez et al.   PLoS One

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells

(2011) Maria Elisabeth Kalland et al.   JOURNAL OF IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

STAT1Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis

(2011) Frank L. van de Veerdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus

(2011) Sebastian Dolff et al.   ARTHRITIS RESEARCH & THERAPY

STAT2 Contributes to Promotion of Colorectal and Skin Carcinogenesis

(2010) A. M. Gamero et al.   Cancer Prevention Research

Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming

(2010) Laura L. Elo et al.   IMMUNITY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

T cells and follicular dendritic cells in germinal center B-cell formation and selection

(2010) Carola G. Vinuesa et al.   IMMUNOLOGICAL REVIEWS

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice

(2010) Julia Menke et al.   KIDNEY INTERNATIONAL

Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients

(2010) H-H. Yu et al.   LUPUS

Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus

(2010) Magdalene Nakou et al.   PLoS One

Identity of mysterious CD4+CD25-Foxp3+ cells in SLE

(2010) David A Horwitz   ARTHRITIS RESEARCH & THERAPY

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

(2009) E. Svenungsson et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of the interferon-γ signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells

(2009) Thomas Karonitsch et al.   ARTHRITIS AND RHEUMATISM

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

(2009) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus Erythematosus

(2009) A. HELLQUIST et al.   JOURNAL OF RHEUMATOLOGY

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

(2009) M Petri et al.   LUPUS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Identification of novel Stat6 regulated proteins in IL-4-treated mouse lymphocytes

(2009) Soile Tuomela et al.   PROTEOMICS

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons

(2009) Westley H. Reeves et al.   TRENDS IN IMMUNOLOGY

Lack of association between the interferon-  signature and longitudinal changes in disease activity in systemic lupus erythematosus

(2008) C Landolt-Marticorena et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus

(2008) B Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

(2008) A-K Abelson et al.   ANNALS OF THE RHEUMATIC DISEASES

Roles of unphosphorylated STATs in signaling

(2008) Jinbo Yang et al.   CELL RESEARCH

Extracellular Signal-Regulated Kinase 5 SUMOylation Antagonizes Shear Stress–Induced Antiinflammatory Response and Endothelial Nitric Oxide Synthase Expression in Endothelial Cells

(2008) Chang-Hoon Woo et al.   CIRCULATION RESEARCH

STAT4: Genetics, mechanisms, and implications for autoimmunity

(2008) Benjamin D. Korman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas

(2008) Ciriaco A Piccirillo et al.   CURRENT OPINION IN IMMUNOLOGY

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

(2008) S. Sigurdsson et al.   HUMAN MOLECULAR GENETICS

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS

IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice

(2008) Donna L. Thibault et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

(2008) N. Wenta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE