期刊
IMMUNOLOGICAL REVIEWS
卷 261, 期 1, 页码 84-101出版社
WILEY
DOI: 10.1111/imr.12198
关键词
neutrophils; macrophages; dendritic cells; cytokines; STAT proteins
类别
资金
- NIH [AI073587, AI098099]
- Amgen Inc
- MD Anderson
- MD Anderson Center for Inflammation and Cancer
- MD Anderson Stem Cell and Developmental Biology Center
- MD Anderson Center for Cancer Epigenetics
- R.E. Bob Smith Fellowship
The term innate immunity typically refers to a quick but non-specific host defense response against invading pathogens. The innate immune system comprises particular immune cell populations, epithelial barriers, and numerous secretory mediators including cytokines, chemokines, and defense peptides. Innate immune cells are also now recognized to play important contributing roles in cancer and pathological inflammatory conditions. Innate immunity relies on rapid signal transduction elicited upon pathogen recognition via pattern recognition receptors (PRRs) and cell: cell communication conducted by soluble mediators, including cytokines. A majority of cytokines involved in innate immune signaling use a molecular cascade encompassing receptor-associated Jak protein tyrosine kinases and STAT (signal transducer and activator of transcription) transcriptional regulators. Here, we focus on roles for STAT proteins in three major innate immune subsets: neutrophils, macrophages, and dendritic cells (DCs). While knowledge in this area is only now emerging, understanding the molecular regulation of these cell types is necessary for developing new approaches to treat human disorders such as inflammatory conditions, autoimmunity, and cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据