标题
Leveraging big data to transform target selection and drug discovery
作者
关键词
-
出版物
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 99, Issue 3, Pages 285-297
出版商
Wiley
发表日期
2015-12-12
DOI
10.1002/cpt.318
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research
- (2015) Bin Chen et al. BMC Medical Genomics
- Public data and open source tools for multi-assay genomic investigation of disease
- (2015) Lavanya Kannan et al. BRIEFINGS IN BIOINFORMATICS
- In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities
- (2015) Carlota Rubio-Perez et al. CANCER CELL
- Elucidating Compound Mechanism of Action by Network Perturbation Analysis
- (2015) Jung Hoon Woo et al. CELL
- Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges
- (2015) Chi-Ping Day et al. CELL
- Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia
- (2015) A. Wagner et al. Molecular Systems Biology
- Reproducibility crisis: Blame it on the antibodies
- (2015) Monya Baker NATURE
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- A New Initiative on Precision Medicine
- (2015) Francis S. Collins et al. NEW ENGLAND JOURNAL OF MEDICINE
- Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
- (2015) Rodolphe Barrangou et al. NUCLEIC ACIDS RESEARCH
- Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway
- (2015) Andrea M. Brum et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and characterization of essential genes in the human genome
- (2015) T. Wang et al. SCIENCE
- Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer
- (2015) Yi Sun et al. Nature Communications
- Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
- (2015) B. Seashore-Ludlow et al. Cancer Discovery
- Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records
- (2015) Hyojung Paik et al. Scientific Reports
- Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models
- (2015) Antonina Mitrofanova et al. Cell Reports
- A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions
- (2015) Francesco Iorio et al. PLoS One
- Novel Drug Candidates for the Treatment of Metastatic Colorectal Cancer through Global Inverse Gene-Expression Profiling
- (2014) V. van Noort et al. CANCER RESEARCH
- HMMR Maintains the Stemness and Tumorigenicity of Glioblastoma Stem-like Cells
- (2014) J. Tilghman et al. CANCER RESEARCH
- Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
- (2014) Yi-Hsin Hsu et al. CANCER RESEARCH
- A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma
- (2014) R. Chen et al. CANCER RESEARCH
- MTBP Is Overexpressed in Triple-Negative Breast Cancer and Contributes to Its Growth and Survival
- (2014) B. C. Grieb et al. MOLECULAR CANCER RESEARCH
- Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer
- (2014) L. F. Zerbini et al. MOLECULAR CANCER THERAPEUTICS
- A draft map of the human proteome
- (2014) Min-Sik Kim et al. NATURE
- A community computational challenge to predict the activity of pairs of compounds
- (2014) Mukesh Bansal et al. NATURE BIOTECHNOLOGY
- A comprehensive transcriptional portrait of human cancer cell lines
- (2014) Christiaan Klijn et al. NATURE BIOTECHNOLOGY
- The Comparative Toxicogenomics Database's 10th year anniversary: update 2015
- (2014) Allan Peter Davis et al. NUCLEIC ACIDS RESEARCH
- Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
- (2014) Maria M. Martins et al. Cancer Discovery
- Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
- (2014) Glenn S Cowley et al. Scientific Data
- An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
- (2013) Amrita Basu et al. CELL
- Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer
- (2013) Hyun Seok Kim et al. CELL
- Network Medicine in Disease Analysis and Therapeutics
- (2013) B Chen et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Validation of the 12-Gene Colon Cancer Recurrence Score in NSABP C-07 As a Predictor of Recurrence in Patients With Stage II and III Colon Cancer Treated With Fluorouracil and Leucovorin (FU/LV) and FU/LV Plus Oxaliplatin
- (2013) Greg Yothers et al. JOURNAL OF CLINICAL ONCOLOGY
- A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation
- (2013) Purvesh Khatri et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma
- (2013) H. W. Lee et al. MOLECULAR CANCER RESEARCH
- Genetics of rheumatoid arthritis contributes to biology and drug discovery
- (2013) Yukinori Okada et al. NATURE
- The big challenges of big data
- (2013) Vivien Marx NATURE
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- Raw data from clinical trials: within reach?
- (2013) Peter Doshi et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Inferring tumour purity and stromal and immune cell admixture from expression data
- (2013) Kosuke Yoshihara et al. Nature Communications
- Evaluating cell lines as tumour models by comparison of genomic profiles
- (2013) Silvia Domcke et al. Nature Communications
- A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
- (2013) N. S. Jahchan et al. Cancer Discovery
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Objective assessment of cancer genes for drug discovery
- (2012) Mishal N. Patel et al. NATURE REVIEWS DRUG DISCOVERY
- Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes
- (2012) K. Kodama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exploiting drug-disease relationships for computational drug repositioning
- (2011) J. T. Dudley et al. BRIEFINGS IN BIOINFORMATICS
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- canSAR: an integrated cancer public translational research and drug discovery resource
- (2011) Mark D. Halling-Brown et al. NUCLEIC ACIDS RESEARCH
- Subtype and pathway specific responses to anticancer compounds in breast cancer
- (2011) L. M. Heiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
- (2011) J. T. Dudley et al. Science Translational Medicine
- Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
- (2011) M. Sirota et al. Science Translational Medicine
- Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
- (2011) Richard Marcotte et al. Cancer Discovery
- Loss of ATM/Chk2/p53 Pathway Components Accelerates Tumor Development and Contributes to Radiation Resistance in Gliomas
- (2010) Massimo Squatrito et al. CANCER CELL
- Relationship Between Tumor Gene Expression and Recurrence in Four Independent Studies of Patients With Stage II/III Colon Cancer Treated With Surgery Alone or Surgery Plus Adjuvant Fluorouracil Plus Leucovorin
- (2010) Michael J. O'Connell et al. JOURNAL OF CLINICAL ONCOLOGY
- International network of cancer genome projects
- (2010) Thomas J. Hudson (Chairperson) et al. NATURE
- Network medicine: a network-based approach to human disease
- (2010) Albert-László Barabási et al. NATURE REVIEWS GENETICS
- Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
- (2010) Eunice L. Kwak et al. NEW ENGLAND JOURNAL OF MEDICINE
- DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
- (2010) C. Knox et al. NUCLEIC ACIDS RESEARCH
- Discovery of drug mode of action and drug repositioning from transcriptional responses
- (2010) F. Iorio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predicting new molecular targets for known drugs
- (2009) Michael J. Keiser et al. NATURE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now