Review
Medicine, General & Internal
Qiang Han, Daming Liu, Peng Zhang
Summary: This study aims to evaluate the efficacy and safety of acupuncture for Crohn's disease. Relevant databases will be searched, and randomized controlled trials evaluating the effects of acupuncture on patients with Crohn's disease will be included. The results will be screened and extracted by two independent reviewers, and bias risk assessment, subgroup analysis, and sensitivity analysis will be conducted.
Review
Medicine, General & Internal
Uchukarn Boonyapo, Alison B. Rushton, Nicola R. Heneghan, Piyameth Dilokthornsakul, Nattawan Phungwattanakul, Taweewat Wiangkham
Summary: Neck pain is a common musculoskeletal complaint, and there is a lack of optimal management specifically for middle-aged or older adults. This study aims to conduct a systematic review and network meta-analysis to determine the best treatment options for this population.
Review
Biochemistry & Molecular Biology
Ana Fajardo-Serrano, Alberto J. Rico, Elvira Roda, Adriana Honrubia, Sandra Arrieta, Goiaz Ariznabarreta, Julia Chocarro, Elena Lorenzo-Ramos, Alvaro Pejenaute, Alfonso Vazquez, Jose Luis Lanciego
Summary: The gene therapy field, particularly targeting neurodegenerative disorders, is currently in the spotlight due to the development of new therapeutics. With the increasing number of ongoing clinical trials, providing advice on the best delivery route for AAV-based therapeutic approaches is crucial for beginners.
Article
Medicine, General & Internal
Margaret C. Smith, Helen Frances Ashdown, James Peter Sheppard, Christopher C. Butler, Clare Bankhead
Summary: A retrospective cohort study in England found that the use of statins in people with COPD was not associated with a decreased risk of COPD exacerbation, contrary to previous observational studies.
Review
Pharmacology & Pharmacy
Lili Zhang, Runyu Miao, Tongyue Yu, Ruonan Wei, Feng Tian, Yishan Huang, Xiaolin Tong, Linhua Zhao
Summary: Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, sodium glucose cotransporter inhibitors, and traditional Chinese medicine have all shown significant efficacy in the treatment of diabetic kidney disease, with the combination of traditional Chinese medicine and angiotensin converting enzyme inhibitors being the most effective option.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Laurel Y. Lee, Arvind K. Pandey, Bradley A. Maron, Joseph Loscalzo
Summary: Network medicine views diseases as the consequences of perturbed interactions between multiple interconnected biological components, facilitating a deeper understanding of complex disease mechanisms. The limitations associated with traditional reductionist analytical methods are apparent, whereas the concept of network medicine provides a new approach to advancing cardiovascular disease research.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Laurel Y. Lee, Arvind K. Pandey, Bradley A. Maron, Joseph Loscalzo
Summary: Network medicine views diseases as consequences of perturbed interactions between multiple interconnected biological components, and plays a crucial role in studying complex disease mechanisms. It has the potential to accelerate cardiovascular disease research and advance precision medicine.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biology
Vivek Sriram, Manu Shivakumar, Sang-Hyuk Jung, Yonghyun Nam, Lisa Bang, Anurag Verma, Seunggeun Lee, Eun Kyung Choe, Dokyoon Kim
Summary: This article introduces a tool for generating disease-disease network visualizations based on summary statistics from phenome-wide association studies. The tool was used to construct a network to study the relationships between human diseases. By analyzing this network, potential genetic explanations for the relationships between diseases can be identified, and a better understanding of the underlying architecture of human diseases can be achieved. This tool can help researchers identify potential genetic targets for drug design and contribute to the exploration of personalized medicine.
Article
Medicine, General & Internal
Tobias B. Polak, David G. J. Cucchi, Jonathan J. Darrow, Matthijs M. Versteegh
Summary: This study evaluates the incremental value of new drugs across various disease areas receiving favorable coverage decisions by the UK's NICE. The findings suggest that the median incremental benefit of these drugs, compared to the best alternative therapeutic option, is equivalent to 3-4 months of life in perfect health. The benefits vary across different drug-indication pairs.
Article
Health Care Sciences & Services
Vivek Sriram, Yonghyun Nam, Manu Shivakumar, Anurag Verma, Sang-Hyuk Jung, Seung Mi Lee, Dokyoon Kim
Summary: This study utilized UKBB data to construct disease networks centered around pregnancy-related disorders, translated network connections into pathologic knowledge using semi-supervised learning, and successfully predicted complication risks for different phenotypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez, Rebecca T. Levinson
Summary: Using systems medicine approaches, we analyzed comorbidity profiles of heart failure patients and identified distinct profiles for HFpEF and HFrEF. This can improve diagnosis and treatment for HFpEF patients.
Review
Integrative & Complementary Medicine
Changning Liu, Lijuan Zhang, Ying Li, Mingxiang Li, Huan Han, Kangfeng Wang
Summary: The study compared the efficacy and safety of Chinese patent medicine with western medicine for the treatment of Alzheimer's disease using Network Meta-analysis. After analyzing 47 studies involving 11 Chinese patent medicines, the results showed that Chinese patent medicine intervention was more effective in improving patient condition and did not significantly increase the risk of adverse reactions. Chinese patent medicine combined with western medicine had statistically significant differences in various assessments compared to western medicine alone and Chinese patent medicine alone. More high-quality studies are needed for further verification.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Medicine, General & Internal
John Sheppard, Bridgitte Shen Lee, Laura M. Periman
Summary: Dry eye disease is a multifactorial disorder characterized by tear film imbalance, which can lead to inflammation and damage of the ocular surface. It affects 5% to 50% of the worldwide population and can be caused by various factors such as ocular and systemic diseases, medications, and environmental conditions. The management of this chronic disease involves both pharmacologic and nonpharmacologic interventions, with primary care clinicians playing a crucial role in diagnosis, education, and referral. It is important for healthcare professionals to be aware of the etiology and treatment options of dry eye disease.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Gihanna Galindez, Sepideh Sadegh, Jan Baumbach, Tim Kacprowski, Markus List
Summary: Molecular interaction networks are the basis for studying the control of biological functions by genes and proteins. Utilizing these networks, researchers have uncovered mechanisms underlying complex diseases. Advancements in omics technologies have enabled large-scale network analysis, and various modeling techniques have proven useful for gaining new insights. This article provides an overview of recent network-based methods and discusses the relevance to biomedical research, highlighting the need for integrative and dynamic network approaches.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Jie Zhu, Qingchun Liang, Siyi He, Chen Wang, Xiafei Lin, Duozhi Wu, Guanwen Lin, Zhihua Wang
Summary: This study conducted a comprehensive investigation on network pharmacology in neurodegenerative diseases using bibliometric analysis. The results showed a steady growth in research on network pharmacology in neurodegenerative diseases from 2008 to 2022, with China, Beijing Univ Chinese Med, Frontiers in Pharmacology, and Geerts H being the most active country, institution, journal, and author, respectively. Moreover, network pharmacology and Alzheimer's disease were identified as the focal areas of current research based on co-cited references and keywords analysis.
FRONTIERS IN PHARMACOLOGY
(2023)
