Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines

A large electronic-health-record-based genome-wide study of serum lipids

(2018) Thomas J. Hoffmann et al.   NATURE GENETICS

The benefit of statins in chronic hepatitis C patients

(2017) Yi-Xiang Zheng et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Annotation-free quantification of RNA splicing using LeafCutter

(2017) Yang I. Li et al.   NATURE GENETICS

Allele-specific expression reveals interactions between genetic variation and environment

(2017) David A Knowles et al.   NATURE METHODS

Ensembl 2018

(2017) Daniel R Zerbino et al.   NUCLEIC ACIDS RESEARCH

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Pleiotropic effects of statins: new therapeutic targets in drug design

(2016) Onkar Bedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin

(2016) Ryosuke Kita et al.   PLoS Genetics

Fast and efficient QTL mapper for thousands of molecular phenotypes

(2015) Halit Ongen et al.   BIOINFORMATICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection

(2015) Minal Çalışkan et al.   PLoS Genetics

Genome-Wide Association Studies in Africans and African Americans: Expanding the Framework of the Genomics of Human Traits and Disease

(2015) Emmanuel Peprah et al.   Public Health Genomics

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

(2014) Ida Moltke et al.   NATURE

GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes

(2014) John D. Eicher et al.   NUCLEIC ACIDS RESEARCH

Ancestry and other genetic associations with plasma PCSK9 response to simvastatin

(2014) Elizabeth Theusch et al.   Pharmacogenetics and Genomics

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

(2014) Iris Postmus et al.   Nature Communications

Relationship of Sex to Diabetes Risk in Statin Trials

(2013) M. O. Goodarzi et al.   DIABETES CARE

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

(2013) Lara M. Mangravite et al.   NATURE

Transcriptome and genome sequencing uncovers functional variation in humans

(2013) Tuuli Lappalainen et al.   NATURE

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

(2012) Hong Yu Wang et al.   BIOCHEMICAL JOURNAL

An Atlas of the Epstein-Barr Virus Transcriptome and Epigenome Reveals Host-Virus Regulatory Interactions

(2012) Aaron Arvey et al.   Cell Host & Microbe

Genetic Determinants of Statin-Induced Low-Density Lipoprotein Cholesterol Reduction

(2012) Daniel I. Chasman et al.   Circulation-Cardiovascular Genetics

MaCH-Admix: Genotype Imputation for Admixed Populations

(2012) Eric Yi Liu et al.   GENETIC EPIDEMIOLOGY

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)

(2012) Harshal A. Deshmukh et al.   JOURNAL OF LIPID RESEARCH

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

(2012) L. B. Barreiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Balancing Selection at the Antiviral Gene OAS1 in Central African Chimpanzees

(2011) William Ferguson et al.   MOLECULAR BIOLOGY AND EVOLUTION

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Genome-wide association studies in pharmacogenomics

(2010) Alison A. Motsinger-Reif et al.   Pharmacogenetics and Genomics

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

(2010) Mathew J. Barber et al.   PLoS One

A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies

(2010) Oliver Stegle et al.   PLoS Computational Biology

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

Transcriptome analysis by strand-specific sequencing of complementary DNA

(2009) Dmitri Parkhomchuk et al.   NUCLEIC ACIDS RESEARCH

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

(2009) Jean K. Lim et al.   PLoS Pathogens

Alternative Splicing of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Is Associated With Plasma Low-Density Lipoprotein Cholesterol Response to Simvastatin

(2008) Marisa Wong Medina et al.   CIRCULATION

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE