标题
Pleiotropic effects of statins: new therapeutic targets in drug design
作者
关键词
Atherosclerotic, Statins, Pleiotropic effects, Anti-inflammatory, Rheumatoid arthritis
出版物
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Volume 389, Issue 7, Pages 695-712
出版商
Springer Nature
发表日期
2016-05-05
DOI
10.1007/s00210-016-1252-4
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The roles of macrophage autophagy in atherosclerosis
- (2016) Bo-zong Shao et al. ACTA PHARMACOLOGICA SINICA
- Inflammatory cytokines in atherosclerosis: current therapeutic approaches
- (2016) Dimitris Tousoulis et al. EUROPEAN HEART JOURNAL
- Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer’s disease cybrid cells
- (2015) Jin-Heon Jeong et al. BMC Neurology
- Statins and Diabetes
- (2015) Kevin C. Maki et al. CARDIOLOGY CLINICS
- A novel therapeutic effect of statins on nephrogenic diabetes insipidus
- (2015) Leonilde Bonfrate et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Statins Do Not Protect Against Cancer: Quite the Opposite
- (2015) Uffe Ravnskov et al. JOURNAL OF CLINICAL ONCOLOGY
- Purinergic signaling in atherosclerosis
- (2015) Davide Ferrari et al. TRENDS IN MOLECULAR MEDICINE
- An investigation into the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomised controlled trials
- (2015) J. Sun et al. BMJ Open
- Statin Therapy and Risk of Fracture
- (2015) Jessica M. Peña et al. JAMA Internal Medicine
- Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms
- (2015) Harumi Okuyama et al. Expert Review of Clinical Pharmacology
- A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors
- (2015) Emilia Mira et al. Oncotarget
- Safety Profile of Subjects Treated to Very Low Low-Density Lipoprotein Cholesterol Levels (
- (2014) Brendan M. Everett et al. AMERICAN JOURNAL OF CARDIOLOGY
- Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway
- (2014) Yini Jiang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Statin-induced myopathies
- (2014) Michał Tomaszewski et al. Pharmacological Reports
- Protective effect of HMG CoA reductase inhibitors against running wheel activity induced fatigue, anxiety like behavior, oxidative stress and mitochondrial dysfunction in mice
- (2014) Anil Kumar et al. Pharmacological Reports
- Effects of peroxisome proliferator-activated receptor γ in simvastatin antiplatelet activity: Influences on cAMP and mitogen-activated protein kinases
- (2014) Hong Du et al. THROMBOSIS RESEARCH
- Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain
- (2014) EmineRabia Koc et al. Noise & Health
- Statins for the primary prevention of cardiovascular disease
- (2014) S. Ebrahim et al. BMJ-British Medical Journal
- Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis
- (2013) Naoki Sawada et al. ANTIOXIDANTS & REDOX SIGNALING
- Statins Exert the Pleiotropic Effects Through Small GTP-Binding Protein Dissociation Stimulator Upregulation With a Resultant Rac1 Degradation
- (2013) Shin-ichi Tanaka et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells
- (2013) Tobias Hilbert et al. BIOCHEMICAL PHARMACOLOGY
- Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes
- (2013) Yu-Miao Wei et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Rosuvastatin may have Neuroprotective Effect on Spinal Cord Ischemia Reperfusion Injury
- (2013) Celal Yavuz et al. CNS & Neurological Disorders-Drug Targets
- Atorvastatin protects against deleterious cardiovascular consequences induced by chronic intermittent hypoxia
- (2013) Perle Totoson et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Statin Therapy for Primary Prevention of Cardiovascular Disease
- (2013) Fiona C. Taylor et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Protective role of atorvastatin against doxorubicin-induced cardiotoxicity and testicular toxicity in mice
- (2013) Ramanjaneyulu SVVS et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Inhibition of Rho and Rac Geranylgeranylation by Atorvastatin Is Critical for Preservation of Endothelial Junction Integrity
- (2013) Hongbing Xiao et al. PLoS One
- Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms
- (2012) Anil Kumar et al. BRAIN RESEARCH
- Pravastatin Provides Antioxidant Activity and Protection Of Erythrocytes Loaded Primaquine
- (2012) Fars Alanazi International Journal of Medical Sciences
- Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells
- (2012) Pietro Enea Lazzerini et al. JOINT BONE SPINE
- Fluvastatin suppresses native and recombinant human P2X4 receptor function
- (2012) Jing Li et al. Purinergic Signalling
- Current and future treatments for Alzheimer’s disease
- (2012) Konstantina G. Yiannopoulou et al. Therapeutic Advances in Neurological Disorders
- Hepatotoxicity associated with statins: Reports of idiosyncratic liver injury post-marketing
- (2011) Einar Björnsson et al. JOURNAL OF HEPATOLOGY
- The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
- (2011) Colin Baigent et al. LANCET
- Fluvastatin modulates renal water reabsorption in vivo through increased AQP2 availability at the apical plasma membrane of collecting duct cells
- (2011) Giuseppe Procino et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- In Vitro Modulation of Peroxisome Proliferator-activated Receptor-γ and Its Genes by C-Reactive Protein. Role of Atorvastatin
- (2010) Nitin Mahajan et al. ARCHIVES OF MEDICAL RESEARCH
- Small leucine-rich proteoglycans in atherosclerotic lesions: novel targets of chronic statin treatment?
- (2010) Andrea Marzoll et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Rebound inflammatory response during the acute phase of myocardial infarction after simvastatin withdrawal
- (2009) Andrei C. Sposito et al. ATHEROSCLEROSIS
- Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1
- (2009) G Heeba et al. BRITISH JOURNAL OF PHARMACOLOGY
- In vitro effects of atorvastatin on lipopolysaccharide-induced gene expression in endometriotic stromal cells
- (2009) Indu Sharma et al. FERTILITY AND STERILITY
- C-reactive protein (CRP) up-regulates expression of receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in THP-1 cells: Inhibitory effects of atorvastatin
- (2009) Nitin Mahajan et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Atorvastatin Ameliorates Sildenafil-Induced Penile Erections in Experimental Diabetes by Inhibiting Diabetes-Induced RhoA/Rho-Kinase Signaling Hyperactivation
- (2009) Annamaria Morelli et al. Journal of Sexual Medicine
- Lipid-lowering therapy and peripheral sensory neuropathy in type 2 diabetes: the Fremantle Diabetes Study
- (2008) T. M. E. Davis et al. DIABETOLOGIA
- Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease
- (2008) Pazit Bar-On et al. JOURNAL OF NEUROCHEMISTRY
- A gift from nature: the birth of the statins
- (2008) Akira Endo NATURE MEDICINE
- Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study
- (2008) C. Cramer et al. NEUROLOGY
- Attenuation of Vascular/Neural Dysfunction in Zucker Rats Treated With Enalapril or Rosuvastatin
- (2008) Christine L Oltman et al. Obesity
- Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
- (2008) Marie-Laure Volvert et al. BMC Pharmacology & Toxicology
- Statins and ATP regulate nuclear pAkt via the P2X7 purinergic receptor in epithelial cells
- (2007) Oras Mistafa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pitavastatin, an HMG-CoA Reductase Inhibitor, Exerts eNOS-Independent Protective Actions Against Angiotensin II–Induced Cardiovascular Remodeling and Renal Insufficiency
- (2007) Shusuke Yagi et al. CIRCULATION RESEARCH
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