Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine

Impairment of intestinal monocarboxylate transporter 6 function and expression in diabetic rats induced by combination of high-fat diet and low dose of streptozocin. Involvement of butyrate-PPARγ activation.

(2019) Feng Xu et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters

(2019) Zhongjian Wang et al.   DRUG METABOLISM AND DISPOSITION

Modulation of expression/function of intestinal P-glycoprotein under disease states

(2019) Teruo Murakami et al.   Expert Opinion on Drug Metabolism & Toxicology

Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells

(2018) João Crispim Encarnação et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

(2018) Sébastien Lucas et al.   Nature Communications

Butyrate: A Double-Edged Sword for Health?

(2018) Hu Liu et al.   Advances in Nutrition

The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

(2018) Meng Li et al.   Frontiers in Pharmacology

Pioglitazone induces hypoxia-inducible factor 1 activation in human renal proximal tubular epithelial cell line HK-2

(2018) Yumiko Urakami-Takebayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells

(2018) Xiaoming Li et al.   BIOCHEMICAL PHARMACOLOGY

Use of a Collagen Membrane to Enhance the Survival of Primary Intestinal Epithelial Cells

(2017) Fiorella Di Claudio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intestinal alkaline phosphatase at the crossroad of intestinal health and disease - a putative role in type 1 diabetes

(2017) M. I. Lassenius et al.   JOURNAL OF INTERNAL MEDICINE

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells

(2017) Un-Ho Jin et al.   Scientific Reports

Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

(2017) Warren N. D’Souza et al.   PLoS One

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study

(2017) Pieter F. de Groot et al.   PLoS One

Commensal gut bacteria modulate phosphorylation-dependent PPARγ transcriptional activity in human intestinal epithelial cells

(2017) Malgorzata Nepelska et al.   Scientific Reports

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Regulation of the placental BCRP transporter by PPAR gamma

(2016) Yixin Lin et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Autocrine Acetylcholine, Induced by IL-17A via NFκB and ERK1/2 Pathway Activation, Promotes MUC5AC and IL-8 Synthesis in Bronchial Epithelial Cells

(2016) Angela Marina Montalbano et al.   MEDIATORS OF INFLAMMATION

Cyanidin-3- O -glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation

(2016) Daniela Ferrari et al.   TOXICOLOGY LETTERS

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Interaction of Drug or Food with Drug Transporters in Intestine and Liver

(2015) Takeo Nakanishi et al.   CURRENT DRUG METABOLISM

Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway

(2015) Tae-Hwan Jung et al.   Nutrition Research and Practice

Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans

(2014) S Rahat-Rozenbloom et al.   INTERNATIONAL JOURNAL OF OBESITY

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

(2014) Mathieu Pizzonero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Molecular Basis of NF-κB Signaling

(2013) Johanna Napetschnig et al.   Annual Review of Biophysics

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ12,14-prostaglandin J2 on the resistance to saquinavir

(2012) Stamatoula Pasvanis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines

(2012) Trinidad Balaguer et al.   BMC MOLECULAR BIOLOGY

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

Acetylation of Retinal Histones in Diabetes Increases Inflammatory Proteins

(2012) Chandra Sekhar Rao Kadiyala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Inflammatory Cytokines and Mitogen-activated Protein Kinases by Acetate in Primary Astrocytes

(2012) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats

(2012) Dan Mei et al.   XENOBIOTICA

The role of P-glycoprotein and breast cancer resistance protein (BCRP) in bacterial attachment to human gastrointestinal cells

(2011) Andrew Crowe   Journal of Crohns & Colitis

Suppression of NF-κB and GSK-3β is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone

(2010) Jung Ok Ban et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Increased Plasma Exposures of Five Protoberberine Alkaloids from Coptidis Rhizoma in Streptozotocin-Induced Diabetic Rats: Is P‐GP Involved?

(2010) Sen Yu et al.   PLANTA MEDICA

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo

(2009) Annika Lehmann et al.   BMC CANCER

Troglitazone inhibits histone deacetylase activity in breast cancer cells

(2009) G.F. Davies et al.   CANCER LETTERS

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Breast Cancer Resistance Protein and P-Glycoprotein Expression in Patients with Newly Diagnosed and Therapy-Refractory Ulcerative Colitis Compared with Healthy Controls

(2008) Heike Gutmann et al.   DIGESTION

Short-Chain Fatty Acids Induce Intestinal Transient Receptor Potential Vanilloid Type 6 Expression in Rats and Caco-2 Cells

(2008) Akiko Fukushima et al.   JOURNAL OF NUTRITION

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics

(2008) S PATHAK et al.   TALANTA