Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters

Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Oatps

(2018) Kazuya Ishida et al.   DRUG METABOLISM AND DISPOSITION

Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein–Drug Interactions: Modulation of Multiple Cytochrome P450 Enzymes by Interleukin-6

(2016) Xiling Jiang et al.   AAPS Journal

Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity

(2016) Ze-yu Zhong et al.   ACTA PHARMACOLOGICA SINICA

Decreased exposure of atorvastatin in diabetic rats partly due to induction of hepatic Cyp3a and Oatp2

(2016) Nan Shu et al.   XENOBIOTICA

Differential Effects of Chrysin on Nitrofurantoin Pharmacokinetics Mediated by Intestinal Breast Cancer Resistance Protein in Rats and Mice

(2016) Atsushi Kawase et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

A Physiologically Based Pharmacokinetic Drug–Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows

(2015) Muhammad Fawad Rasool et al.   CLINICAL PHARMACOKINETICS

Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats

(2015) Shuwen Jiang et al.   Drug Metabolism and Pharmacokinetics

Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes

(2014) Dan Xu et al.   ACTA PHARMACOLOGICA SINICA

A clinician's guide to statin drug-drug interactions

(2014) Kenneth A. Kellick et al.   Journal of Clinical Lipidology

The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats

(2014) Ling-ling Jia et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human

(2013) Jian Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Mechanistic Physiologically Based Pharmacokinetic-Enzyme Turnover Model Involving both Intestine and Liver to Predict CYP3A Induction-Mediated Drug–Drug Interactions

(2013) Haifang Guo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Diabetes Mellitus on Pharmacokinetic and Pharmacodynamic Properties of Drugs

(2012) Miroslav Dostalek et al.   CLINICAL PHARMACOKINETICS

Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats

(2012) Dan Mei et al.   XENOBIOTICA

Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

(2011) K Maeda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs

(2011) Y. Yabe et al.   DRUG METABOLISM AND DISPOSITION

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Impact ofSLCO1B1(OATP1B1) andABCG2(BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins

(2011) Grant T. Generaux et al.   XENOBIOTICA

Opposite Effect of Diabetes Mellitus Induced by Streptozotocin on Oral and Intravenous Pharmacokinetics of Verapamil in Rats

(2010) N. Hu et al.   DRUG METABOLISM AND DISPOSITION

Hepatitis C Virus-related Cirrhosis is a Major Determinant of the Expression Levels of Hepatic Drug Transporters

(2010) Ken Ogasawara et al.   Drug Metabolism and Pharmacokinetics

Regional absorption of fexofenadine in rat intestine

(2010) Caroline MacLean et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Increased Plasma Exposures of Five Protoberberine Alkaloids from Coptidis Rhizoma in Streptozotocin-Induced Diabetic Rats: Is P‐GP Involved?

(2010) Sen Yu et al.   PLANTA MEDICA

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Effects of cyclosporin A and itraconazole on the pharmacokinetics of atorvastatin in rats1

(2008) Jing DONG et al.   ACTA PHARMACOLOGICA SINICA

Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes

(2008) K. Grime et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

(2008) S. W. Paine et al.   DRUG METABOLISM AND DISPOSITION

Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats

(2008) D. Mitschke et al.   DRUG METABOLISM AND DISPOSITION

Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3

(2008) Chunshan Gui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY