Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathobiology and Potential Therapeutic Value of Intestinal Short-Chain Fatty Acids in Gut Inflammation and Obesity

(2013) Jessica Soldavini et al.   DIGESTIVE DISEASES AND SCIENCES

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

G Protein-Coupled Receptor 43 Moderates Gut Inflammation Through Cytokine Regulation from Mononuclear Cells

(2013) Ryuta Masui et al.   INFLAMMATORY BOWEL DISEASES

Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8

(2013) Tsuyoshi Mishiro et al.   LABORATORY INVESTIGATION

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

(2012) Hong-Bo Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis

(2011) Erica L.M. Vieira et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

(2010) R. DUCHMANN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Importance of disrupted intestinal barrier in inflammatory bowel diseases

(2010) Saʼad Y. Salim et al.   INFLAMMATORY BOWEL DISEASES

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

(2009) Yingcai Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

(2009) C. Sina et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability

(2008) Takuya Suzuki et al.   BRITISH JOURNAL OF NUTRITION

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

(2008) T. Lee et al.   MOLECULAR PHARMACOLOGY

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH