The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Glycation potentiates neurodegeneration in models of Huntington’s disease

(2016) Hugo Vicente Miranda et al.   Scientific Reports

The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

(2015) Xiqun Chen et al.   PLoS One

The Discovery of a Highly Selective 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

(2014) Paolo Di Fruscia et al.   ChemMedChem

(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy

(2014) Diana Macedo et al.   HUMAN MOLECULAR GENETICS

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Systemic regulation of mammalian ageing and longevity by brain sirtuins

(2014) Akiko Satoh et al.   Nature Communications

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

(2014) Luis Fonseca-Ornelas et al.   Nature Communications

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

(2013) Grit Taschenberger et al.   ANNALS OF NEUROLOGY

SIRT1 and SIRT2: emerging targets in neurodegeneration

(2013) Gizem Donmez et al.   EMBO Molecular Medicine

Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications

(2013) Hugo Vicente Miranda et al.   JOURNAL OF NEUROCHEMISTRY

PLK2 Modulates α-Synuclein Aggregation in Yeast and Mammalian Cells

(2013) Elisa Basso et al.   MOLECULAR NEUROBIOLOGY

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology

(2012) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

(2012) Patrícia Silva Guerreiro et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice

(2012) Éva M. Szegő et al.   NEUROBIOLOGY OF AGING

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

SIRT2 as a Therapeutic Target for Age-Related Disorders

(2012) Rita Machado de Oliveira et al.   Frontiers in Pharmacology

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice

(2011) Éva M. Szegő et al.   NEUROBIOLOGY OF DISEASE

mMass3: A Cross-Platform Software Environment for Precise Analysis of Mass Spectrometric Data

(2010) Martin Strohalm et al.   ANALYTICAL CHEMISTRY

Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death

(2010) Ying Zhao et al.   Autophagy

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

The sour side of neurodegenerative disorders: the effects of protein glycation

(2009) Hugo Vicente Miranda et al.   JOURNAL OF PATHOLOGY