N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid-State 13C NMR Reveals Annealing of Raft-Like Membranes Containing Cholesterol by the Intrinsically Disordered Protein α-Synuclein

(2013) Avigdor Leftin et al.   JOURNAL OF MOLECULAR BIOLOGY

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans

(2012) Gusheng Wu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients

(2012) Jay S. Schneider et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

(2012) Adam J. Trexler et al.   PROTEIN SCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Mice Lacking Major Brain Gangliosides Develop Parkinsonism

(2011) Gusheng Wu et al.   NEUROCHEMICAL RESEARCH

Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method

(2011) Annika Öhrfelt et al.   NEUROCHEMICAL RESEARCH

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

GM1 ganglioside in Parkinson's disease: Results of a five year open study

(2010) Jay S. Schneider et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli

(2010) Matthew Johnson et al.   PLoS One

Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants

(2009) Jason D. Perlmutter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET