Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19
出版年份 2020 全文链接
标题
Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19
作者
关键词
-
出版物
Journal of Clinical Medicine
Volume 9, Issue 4, Pages 1131
出版商
MDPI AG
发表日期
2020-04-16
DOI
10.3390/jcm9041131
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
- (2020) Aiping Wu et al. Cell Host & Microbe
- Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- (2020) Manli Wang et al. CELL RESEARCH
- Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
- (2020) Shuai Xia et al. Cellular & Molecular Immunology
- Chloroquine and hydroxychloroquine as available weapons to fight COVID-19
- (2020) Philippe Colson et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges
- (2020) Chih-Cheng Lai et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Roles of Reconstituted High-Density Lipoprotein Nanoparticles in Cardiovascular Disease: A New Paradigm for Drug Discovery
- (2020) Jiansheng Huang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- 2019 Novel Coronavirus—Important Information for Clinicians
- (2020) Carlos del Rio et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China
- (2020) Wenjie Yang et al. JOURNAL OF INFECTION
- Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV
- (2020) Jia Liu et al. JOURNAL OF MEDICAL VIROLOGY
- Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection
- (2020) Jianhua Xia et al. JOURNAL OF MEDICAL VIROLOGY
- Data sharing and outbreaks: best practice exemplified
- (2020) David L Heymann LANCET
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
- (2020) Roujian Lu et al. LANCET
- A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
- (2020) Jasper Fuk-Woo Chan et al. LANCET
- Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
- (2020) Nanshan Chen et al. LANCET
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- Is COVID-19 receiving ADE from other coronaviruses?
- (2020) Jason A. Tetro MICROBES AND INFECTION
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- Therapeutic options for the 2019 novel coronavirus (2019-nCoV)
- (2020) Guangdi Li et al. NATURE REVIEWS DRUG DISCOVERY
- Clinical Characteristics of Coronavirus Disease 2019 in China
- (2020) Wei-jie Guan et al. NEW ENGLAND JOURNAL OF MEDICINE
- First Case of 2019 Novel Coronavirus in the United States
- (2020) Michelle L. Holshue et al. NEW ENGLAND JOURNAL OF MEDICINE
- Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
- (2020) Qun Li et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
- (2020) Emmie de Wit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia
- (2020) Junqiang Lei et al. RADIOLOGY
- Coronavirus epidemic snarls science worldwide
- (2020) Robert F. Service SCIENCE
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- SR-BI as a target of natural products and its significance in cancer
- (2020) Dongdong Wang et al. SEMINARS IN CANCER BIOLOGY
- Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
- (2020) Timothy P. Sheahan et al. Nature Communications
- Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series
- (2020) Xiao-Wei Xu et al. BMJ-British Medical Journal
- Pathological findings of COVID-19 associated with acute respiratory distress syndrome
- (2020) Zhe Xu et al. Lancet Respiratory Medicine
- On the origin and continuing evolution of SARS-CoV-2
- (2020) Xiaolu Tang et al. National Science Review
- Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses
- (2020) Michael Letko et al. Nature Microbiology
- The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights
- (2020) Hiroshi Nishiura et al. Journal of Clinical Medicine
- Novel Coronavirus Outbreak in Wuhan, China, 2020: Intense Surveillance Is Vital for Preventing Sustained Transmission in New Locations
- (2020) Robin N. Thompson Journal of Clinical Medicine
- Initial Cluster of Novel Coronavirus (2019-nCoV) Infections in Wuhan, China Is Consistent with Substantial Human-to-Human Transmission
- (2020) Hiroshi Nishiura et al. Journal of Clinical Medicine
- Bi-directional differentiation of single bronchioalveolar stem cells during lung repair
- (2020) Kuo Liu et al. Cell Discovery
- The Use of Antimalarial Drugs against Viral Infection
- (2020) Sarah D’Alessandro et al. Microorganisms
- The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
- (2020) B. Coutard et al. ANTIVIRAL RESEARCH
- Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?
- (2020) Undurti N. Das ARCHIVES OF MEDICAL RESEARCH
- Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
- (2020) Junwen Luan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus
- (2020) Sen Liu et al. BIOINFORMATICS
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
- (2020) Shuai Xia et al. CELL RESEARCH
- Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
- (2020) Wanbo Tai et al. Cellular & Molecular Immunology
- Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
- (2020) Daniel Batlle et al. CLINICAL SCIENCE
- Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)
- (2020) Waleed Alhazzani et al. CRITICAL CARE MEDICINE
- SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells
- (2020) Soeren Lukassen et al. EMBO JOURNAL
- SARS-CoV-2, COVID-19, and inherited arrhythmia syndromes
- (2020) Cheng-I. Wu et al. HEART RHYTHM
- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
- (2020) Philippe Gautret et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Community Prevalence of SARS-CoV-2 Among Patients With Influenzalike Illnesses Presenting to a Los Angeles Medical Center in March 2020
- (2020) Brad Spellberg et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Turbulent Gas Clouds and Respiratory Pathogen Emissions
- (2020) Lydia Bourouiba JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach
- (2020) Salman Ali Khan et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19
- (2020) Nisha Muralidharan et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Potential therapeutic agents against COVID-19
- (2020) Chih-Chia Lu et al. Journal of the Chinese Medical Association
- SARS-CoV-2: a time for clear and immediate action
- (2020) Gregory A Poland LANCET INFECTIOUS DISEASES
- A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
- (2020) Bin Cao et al. NEW ENGLAND JOURNAL OF MEDICINE
- News Feature: Avoiding pitfalls in the pursuit of a COVID-19 vaccine
- (2020) Lynne Peeples PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
- (2020) Meng Yuan et al. SCIENCE
- Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)
- (2020) Ruiyun Li et al. SCIENCE
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- (2020) Timothy P. Sheahan et al. Science Translational Medicine
- Macrolide treatment for COVID-19: Will this be the way forward?
- (2020) Masashi Ohe et al. BioScience Trends
- Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
- (2020) Jianjun Gao et al. BioScience Trends
- Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence
- (2020) Yu-chen Cao et al. Travel Medicine and Infectious Disease
- Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China
- (2020) Ping Wu et al. JAMA Ophthalmology
- A Systematic Review of COVID-19 Epidemiology Based on Current Evidence
- (2020) Minah Park et al. Journal of Clinical Medicine
- Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)
- (2020) Samuel James Brake et al. Journal of Clinical Medicine
- Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
- (2020) Yadi Zhou et al. Cell Discovery
- Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis
- (2019) Justin T. Marinko et al. CHEMICAL REVIEWS
- IL-1 Inhibition and Function of the HDL-Containing Fraction of Plasma in Patients with Stages 3 to 5 CKD
- (2019) Adriana M. Hung et al. Clinical Journal of the American Society of Nephrology
- Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
- (2019) Egor Tchesnokov et al. Viruses-Basel
- Human Coronavirus: Host-Pathogen Interaction
- (2019) To Sing Fung et al. Annual Review of Microbiology
- SHERLOCK: nucleic acid detection with CRISPR nucleases
- (2019) Max J. Kellner et al. Nature Protocols
- Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach
- (2019) Junwei Zhou et al. FASEB JOURNAL
- Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
- (2019) Young-Jun Park et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
- (2019) Nils C. Gassen et al. Nature Communications
- Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses
- (2018) Jeong-Joong Yoon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications
- (2018) Mehdi Sharifi-Rad et al. MICROBIOLOGICAL RESEARCH
- Ebola outbreak prompts experimental drug rollout
- (2018) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution
- (2018) Sangita Venkataraman et al. Viruses-Basel
- Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
- (2018) Maria L. Agostini et al. mBio
- Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations
- (2018) Hui Huang et al. Science Advances
- Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
- (2018) Robert N. Kirchdoerfer et al. Scientific Reports
- Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun
- (2017) To Sing Fung et al. Cell Death & Disease
- A Role for Neutrophils in Viral Respiratory Disease
- (2017) Jeremy V. Camp et al. Frontiers in Immunology
- Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems
- (2016) Jiansheng Huang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
- (2016) Alexandra East-Seletsky et al. NATURE
- Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol
- (2016) Rameshwar U. Kadam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Stress Responses and Translational Control by Coronavirus
- (2016) To Fung et al. Viruses-Basel
- Inactivation of myeloperoxidase by benzoic acid hydrazide
- (2015) Jiansheng Huang et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities
- (2015) Christoph Reiter et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
- (2015) Hin Chu et al. JOURNAL OF INFECTIOUS DISEASES
- The Endoplasmic Reticulum Stress Sensor IRE1 Protects Cells from Apoptosis Induced by the Coronavirus Infectious Bronchitis Virus
- (2014) T. S. Fung et al. JOURNAL OF VIROLOGY
- Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus
- (2014) Anna Lundin et al. PLoS Pathogens
- Coronavirus infection, ER stress, apoptosis and innate immunity
- (2014) To S. Fung et al. Frontiers in Microbiology
- Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
- (2013) Andy Kilianski et al. ANTIVIRAL RESEARCH
- Organization of the ER–Golgi interface for membrane traffic control
- (2013) Federica Brandizzi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety
- (2012) Sho Konno et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
- (2012) Jon Jacobs et al. JOURNAL OF MEDICINAL CHEMISTRY
- Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis
- (2011) Teluguakula Narasaraju et al. AMERICAN JOURNAL OF PATHOLOGY
- Human Coronavirus-Induced Neuronal Programmed Cell Death Is Cyclophilin D Dependent and Potentially Caspase Dispensable
- (2011) D. J. Favreau et al. JOURNAL OF VIROLOGY
- Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection
- (2011) Ryuichi Sugamata et al. MICROBIOLOGY AND IMMUNOLOGY
- An Artemisinin-Derived Dimer Has Highly Potent Anti-Cytomegalovirus (CMV) and Anti-Cancer Activities
- (2011) Ran He et al. PLoS One
- Computational Approaches for the Discovery of Cysteine Protease Inhibitors Against Malaria and SARS
- (2010) Falgun Shah et al. Current Computer-Aided Drug Design
- Inhibition of HIV-1 entry by extracts derived from traditional Chinese medicinal herbal plants
- (2009) In-Woo Park et al. BMC Complementary and Alternative Medicine
- Coronavirus Nucleocapsid Protein Facilitates Template Switching and Is Required for Efficient Transcription
- (2009) S. Zuniga et al. JOURNAL OF VIROLOGY
- The spike protein of SARS-CoV — a target for vaccine and therapeutic development
- (2009) Lanying Du et al. NATURE REVIEWS MICROBIOLOGY
- Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
- (2009) S. Belouzard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-based virtual screening against SARS-3CLpro to identify novel non-peptidic hits
- (2008) Prasenjit Mukherjee et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication
- (2008) Chia-Hsin Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The M, E, and N Structural Proteins of the Severe Acute Respiratory Syndrome Coronavirus Are Required for Efficient Assembly, Trafficking, and Release of Virus-Like Particles
- (2008) Y. L. Siu et al. JOURNAL OF VIROLOGY
- Analysis of severe acute respiratory syndrome coronavirus structural proteins in virus-like particle assembly
- (2008) Mina Nakauchi et al. MICROBIOLOGY AND IMMUNOLOGY
- Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein
- (2007) Kelly-Anne Spencer et al. VIROLOGY
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