Review of Atypical Organometallic Compounds as Antimalarial Drugs

Current scenario of ferrocene-containing hybrids for antimalarial activity

(2019) Jiaqi Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug targets for resistant malaria: Historic to future perspectives

(2018) Sahil Kumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Quinoline-Based Hybrid Compounds with Antimalarial Activity

(2017) Xhamla Nqoro et al.   MOLECULES

Is the Mitochondrion a Good Malaria Drug Target?

(2017) Christopher D. Goodman et al.   TRENDS IN PARASITOLOGY

Ferroquine, the next generation antimalarial drug, has antitumor activity

(2017) Artem Kondratskyi et al.   Scientific Reports

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

(2016) James S. McCarthy et al.   MALARIA JOURNAL

Ferroquine and its derivatives: New generation of antimalarial agents

(2015) Waseem A. Wani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria

(2015) Sahil Kumar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

(2015) Nicolli Bellotti de Souza et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine

(2015) Katy N. Olafson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

(2014) Wesley Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influence of host iron status on Plasmodium falciparum infection

(2014) Martha A. Clark et al.   Frontiers in Pharmacology

The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

(2013) Faustine Dubar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organometallic benzimidazoles: Synthesis, characterization and antimalarial activity

(2013) Patricia Toro et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Structural Characteristics of Chloroquine-Bridged Ferrocenophane Analogues of Ferroquine May Obviate Malaria Drug-Resistance Mechanisms

(2013) Paloma F. Salas et al.   JOURNAL OF MEDICINAL CHEMISTRY

The antimalarial ferroquine: from bench to clinic

(2013) C. Biot et al.   Parasite

Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children

(2012) M. Gwamaka et al.   CLINICAL INFECTIOUS DISEASES

The potential of organometallic complexes in medicinal chemistry

(2012) Gilles Gasser et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cyrhetrenyl chalcones: Synthesis, characterization and antimalarial evaluation

(2012) Rodrigo Arancibia et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Bioorganometallic Compounds with Antimalarial Targets: Inhibiting Hemozoin Formation

(2012) Maribel Navarro et al.   ORGANOMETALLICS

Plasmodium falciparum Apicoplast Drugs: Targets or Off-Targets?

(2011) Cyrille Y. Botté et al.   CHEMICAL REVIEWS

Synthesis, characterization and antimalarial activity of new chromium arene–quinoline half sandwich complexes

(2011) Lotta Glans et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

“Medicinal Organometallic Chemistry”

(2011) Simon P. Fricker  

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

(2010) Faustine Dubar et al.   ACS Chemical Biology

Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure

(2010) Rodrigo Arancibia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trioxaferroquines as New Hybrid Antimalarial Drugs

(2010) François Bellot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ferrocene–indole hybrids for cancer and malaria therapy

(2010) Josefina Quirante et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

The evolution, metabolism and functions of the apicoplast

(2010) L. Lim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

On the Mechanism of Chloroquine Resistance in Plasmodium falciparum

(2010) Mauro Chinappi et al.   PLoS One

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

(2009) Natascha Chavain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiparasitic and immunomodulatory activities of 1,1-bis(4-hydroxyphenyl)-2-phenyl-but-1-ene and its protected and free 2-ferrocenyl derivatives

(2009) Milena B.P. Soares et al.   DRUG DEVELOPMENT RESEARCH

Enhancement of the Antimalarial Activity of Ciprofloxacin Using a Double Prodrug/Bioorganometallic Approach

(2009) Faustine Dubar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interplay Between Malaria, Crystalline Hemozoin Formation, and Antimalarial Drug Action and Design

(2008) Isabelle Weissbuch et al.   CHEMICAL REVIEWS

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Investigation of the Redox Behavior of Ferroquine, a New Antimalarial

(2008) Natascha Chavain et al.   MOLECULAR PHARMACEUTICS

Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action

(2008) Faustine Dubar et al.   MOLECULES

Ferrocene Conjugates of Chloroquine and other Antimalarials: the Development of Ferroquine, a New Antimalarial

(2007) Daniel Dive et al.   ChemMedChem