Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

Antimalarial compounds in Phase II clinical development

(2015) Jana Held et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Molecular Mechanism of Action of 2-Ferrocenyl-1,1-diphenylbut-1-ene on HL-60 Leukemia Cells

(2014) Alane Cabral de Oliveira et al.   ChemMedChem

Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity

(2014) Martina Gobec et al.   DALTON TRANSACTIONS

Antiparasitic activities of novel ruthenium/lapachol complexes

(2014) Marília I.F. Barbosa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

(2014) Anna Citta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative Sequence of a Ruthenocene-Based Anticancer Drug Candidate in a Basic Environment

(2014) Hui Zhi Shirley Lee et al.   ORGANOMETALLICS

Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics

(2013) Michaela Wenzel et al.   ACS Chemical Biology

Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon

(2013) Marly M. Marques et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(ii)–arene complexes

(2013) Muneebah Adams et al.   DALTON TRANSACTIONS

Synthesis and antiproliferative activity of hydroxyferrocifen hybrids against triple-negative breast cancer cells

(2013) José de Jesús Cázares-Marinero et al.   DALTON TRANSACTIONS

Synthesis and evaluation of new polynuclear organometallic Ru(ii), Rh(iii) and Ir(iii) pyridyl ester complexes as in vitro antiparasitic and antitumor agents

(2013) Prinessa Chellan et al.   DALTON TRANSACTIONS

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Di- and Trinuclear Ruthenium-, Rhodium-, and Iridium-Functionalized Pyridyl Aromatic Ethers: A New Class of Antiparasitic Agents

(2013) Prinessa Chellan et al.   ORGANOMETALLICS

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

(2013) M. Chugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells

(2012) Yong Leng Kelvin Tan et al.   DALTON TRANSACTIONS

Ruthenium(ii) arene complexes with chelating chloroquine analogue ligands: Synthesis, characterization and in vitro antimalarial activity

(2012) Lotta Glans et al.   DALTON TRANSACTIONS

The therapeutic potential of metal-based antimalarial agents: Implications for the mechanism of action

(2012) Christophe Biot et al.   DALTON TRANSACTIONS

Perspectives on what ruthenium-based compounds could offer in the development of potential antiparasitic drugs

(2012) Dinorah Gambino et al.   INORGANICA CHIMICA ACTA

Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells

(2012) Alberto Martínez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes

(2012) Christophe Biot et al.   Metallomics

Introduction to the Organometallics in Biology and Medicine Issue

(2012) Michael P. Coogan et al.   ORGANOMETALLICS

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

(2011) Faustine Dubar et al.   CHEMICAL COMMUNICATIONS

Biological evaluation of twenty-eight ferrocenyl tetrasubstituted olefins: Cancer cell growth inhibition, ROS production and hemolytic activity

(2011) Alane Cabral de Oliveira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

(2010) Faustine Dubar et al.   ACS Chemical Biology

Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells

(2010) Meral Görmen et al.   ChemMedChem

Synthetic and Mechanistic Pathways ofCisandTrans-Hydroxytamoxifen Drug Derivatives Reacting with Cp*Rh Complexes that involve η1-N, η2-N,O, η1-O, and η6Bonding Modes, via a Novel N-π Rearrangement; Relative Binding Affinities and Computer Docking Studies ofCis and Trans-η6-Cp*Rh-Hydroxytamoxifen Complexes at the Estrogen, ERα and ERβ Receptors, and Growth Inhibition to Breast Cancer Cells

(2010) Siden Top et al.   INORGANIC CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series

(2010) Mehdi El Arbi et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Cysteine proteases as targets for metal-based drugs

(2010) Simon P. Fricker   Metallomics

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

(2010) Meral Görmen et al.   MedChemComm

Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

(2009) Didier Hamels et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, Characterization, and in vitro Antimalarial and Antitumor Activity of New Ruthenium(II) Complexes of Chloroquine

(2009) Chandima S. K. Rajapakse et al.   INORGANIC CHEMISTRY

One-Electron Oxidation of Ruthenocene: Reactions of the Ruthenocenium Ion in Gentle Electrolyte Media

(2009) Jannie C. Swarts et al.   INORGANIC CHEMISTRY

The antimalarial activity of Ru–chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces

(2009) Alberto Martínez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ferrocenyl compounds possessing protected phenol and thiophenol groups: Synthesis, X-ray structure, and in vitro biological effects against breast cancer

(2008) Julia B. Heilmann et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY