期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 53, 期 10, 页码 4103-4109出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm100117e
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资金
- Palumed Co.
- ANR [ANR-06-RIB-020-02]
The synthesis, characterization, and antimalarial evaluation of a new series of potential antimalarial molecules, named trioxaferroquines, are reported. Trioxaferroquines are hybrid antimalarial drugs containing a 1,2,4-trioxane covalently linked to ferroquine (Fq), a synthetic ferrocenylquinoline derivative currently under clinical development. The aim was to combine, within a single structure, an iron(II) species, a 1,2,4-trioxane, as in artemisinin, and a substituted quinoline, as in chloroquine.
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