期刊
INORGANIC CHEMISTRY COMMUNICATIONS
卷 35, 期 -, 页码 126-129出版社
ELSEVIER
DOI: 10.1016/j.inoche.2013.06.019
关键词
Plasmodium falciparum; Antimalarial; Resistance; Cyrhetrene; Ferrocene; Benzimidazoles
资金
- FONDECYT-Chile [1110669, 3120091]
- Pontificia Universidad Catolica de Valparaiso
- MECESUP
- CONICYT
- D.I.-PUCV
- Ministry of Defense (Delegation Generale pour l'Armement)
- Direction Centrale du Service de Sante des Armees [10co405]
A series of ferrocenyl and cyrhetrenyl benzimidazoles were synthesized and characterized. The condensation-cyclization reaction of cyrhetrenecarbaldehyde with 1,2-phenylendiamine or 4-nitro-1,2-phenylendiamine produces only the 2-cyrhetrenyl-benzimidazoles [1-Re-(H, NO2)] whereas with the same diamines, ferrocenecarbaldehyde yields two products: 2-ferrocenyl-benzimidazole [1-Fe-(H, NO2)] and N-ferrocenylmethy1-2-ferrocenylbenzimidazole [2-Fe-(H, NO2)]. The structures of all products were confirmed by H-1, C-13 NMR spectra and MS. The molecular structure of 2-Fe-NO2 was determined by single crystal X-ray analysis. The antimalarial evaluation studies against the CQ susceptible-strain (3D7) and the CQ resistant-strain (W2) of Plasmodium falciparum revealed cyrhetrene conjugates to be most potent of the tested compounds. The presence of the nitro group at the 5-position of organometallic-benzimidazoles [1-M (M = Re, Fe)] also increases the antimalarial activity. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据