The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease

(2019) Sim K. Singhrao et al.   Journal of Oral Microbiology

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort

(2019) Ping Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic inflammation linking chronic periodontitis to cognitive decline

(2019) Rachel Pei-Hsuan Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Time to test antibacterial therapy in Alzheimer’s disease

(2019) Francesco Panza et al.   BRAIN

Analysis of Salivary Microbiome in Patients with Alzheimer’s Disease

(2019) Xi-Xi Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer’s disease?

(2019) Ingar Olsen et al.   Journal of Oral Microbiology

Neurotransmitter modulation by the gut microbiota

(2018) Philip Strandwitz   BRAIN RESEARCH

Impact of gut microbiota on neurological diseases: Diet composition and novel treatments

(2018) Ana Larroya-García et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease

(2018) Bo Cui et al.   Journal of Neuroinflammation

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

(2018) JACOB M. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration

(2018) Yuhai Zhao et al.   MOLECULAR NEUROBIOLOGY

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiome-metabolome signatures in mice genetically prone to develop dementia, fed a normal or fatty diet

(2018) Elena Sanguinetti et al.   Scientific Reports

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

(2018) Xinhua Zhan et al.   Frontiers in Aging Neuroscience

Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice

(2018) Dan Zhu et al.   Biomed Research International

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition

(2018) Jessica A. Deaver et al.   Frontiers in Microbiology

Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease

(2018) Dawn M. Fernandez et al.   Frontiers in Physiology

Crosstalk Between Gut Microbiota and the Central Nervous System: A Focus for Alzheimer's Disease

(2018) Vilma Maria Junges et al.   Current Alzheimer Research

Trends in Diet and Alzheimer's Disease During the Nutrition Transition in Japan and Developing Countries

(2018) William B. Grant   JOURNAL OF ALZHEIMERS DISEASE

Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?

(2018) Annalia Asti et al.   JOURNAL OF ALZHEIMERS DISEASE

Are noise and air pollution related to the incidence of dementia? A cohort study in London, England

(2018) Iain M Carey et al.   BMJ Open

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

(2018) Dora Abraham et al.   EXPERIMENTAL GERONTOLOGY

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study

(2017) Barbara Fenesi et al.   JOURNAL OF ALZHEIMERS DISEASE

Human and rat gut microbiome composition is maintained following sleep restriction

(2017) Shirley L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults

(2017) Jason R. Anderson et al.   SLEEP MEDICINE

Microbiota-gut-brain axis and the central nervous system

(2017) Xiqun Zhu et al.   Oncotarget

Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

(2017) Chang-Kai Chen et al.   Alzheimers Research & Therapy

Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition

(2017) Alice Harding et al.   Frontiers in Aging Neuroscience

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Linking the Gut Microbial Ecosystem with the Environment: Does Gut Health Depend on Where We Live?

(2017) Nishat Tasnim et al.   Frontiers in Microbiology

Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer’s disease-like tau hyperphosphorylation

(2017) Zhihui Gai et al.   Environmental Health and Preventive Medicine

Differences in gut microbiota profile between women with active lifestyle and sedentary women

(2017) Carlo Bressa et al.   PLoS One

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

(2017) Kyong Nyon Nam et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer's Disease

(2016) William B. Grant   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

(2016) Nian-Sheng Tzeng et al.   NEUROEPIDEMIOLOGY

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

(2016) Martin Prince et al.   Alzheimers Research & Therapy

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals

(2016) Christian Benedict et al.   Molecular Metabolism

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration

(2016) Surjyadipta Bhattacharjee et al.   PLoS One

Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice

(2016) Valeriy A. Poroyko et al.   Scientific Reports

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Bifidobacteria modulate cognitive processes in an anxious mouse strain

(2015) H.M. Savignac et al.   BEHAVIOURAL BRAIN RESEARCH

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

(2015) Anastasia I. Petra et al.   CLINICAL THERAPEUTICS

Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes

(2015) Guillaume Perriard et al.   Journal of Neuroinflammation

IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation

(2015) Jie Sun et al.   Journal of Neuroinflammation

Brain-derived neurotrophic factor and TrkB expression in the “oldest-old,” the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta

(2015) Bernadeta Michalski et al.   NEUROBIOLOGY OF AGING

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

(2015) S. Liang et al.   NEUROSCIENCE

Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer’s Disease-Like Amyloid-β Pathology and Neuroinflammation in the Rat Hippocampus

(2015) Bo Cui et al.   Scientific Reports

Lactobacillus fermentumNS9 restores the antibiotic induced physiological and psychological abnormalities in rats

(2015) T. Wang et al.   Beneficial Microbes

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

Circadian clock disruption in neurodegenerative diseases: cause and effect?

(2015) Erik S. Musiek   Frontiers in Pharmacology

Missing the Dark: Health Effects of Light Pollution

(2014) Ron Chepesiuk   ENVIRONMENTAL HEALTH PERSPECTIVES

Early-onset Alzheimer's disease: a global cross-sectional analysis

(2014) P. K. Panegyres et al.   EUROPEAN JOURNAL OF NEUROLOGY

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

(2014) Glenn J. Rapsinski et al.   INFECTION AND IMMUNITY

Lactobacillus helveticus–fermented milk improves learning and memory in mice

(2014) Kazuhito Ohsawa et al.   NUTRITIONAL NEUROSCIENCE

Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat

(2014) Jia Luo et al.   Science China-Life Sciences

Environmental factors in the development and progression of late-onset Alzheimer’s disease

(2014) Moses N. Wainaina et al.   Neuroscience Bulletin

Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men

(2014) Sharon Ooms et al.   JAMA Neurology

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Microbial amyloids – functions and interactions within the host

(2013) Kelly Schwartz et al.   CURRENT OPINION IN MICROBIOLOGY

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Chronic noise exposure and Alzheimer disease: Is there an etiological association?

(2013) Bo Cui et al.   MEDICAL HYPOTHESES

Sleep and Alzheimer disease pathology—a bidirectional relationship

(2013) Yo-El S. Ju et al.   Nature Reviews Neurology

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Disease to Dirt: The Biology of Microbial Amyloids

(2013) David A. Hufnagel et al.   PLoS Pathogens

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse

(2012) Marielle S. Kahn et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex

(2012) Bo Cui et al.   EXPERIMENTAL NEUROLOGY

Microbial Amyloids Induce Interleukin 17A (IL-17A) and IL-22 Responses via Toll-Like Receptor 2 Activation in the Intestinal Mucosa

(2012) Jessalyn H. Nishimori et al.   INFECTION AND IMMUNITY

Dentition, Dental Health Habits, and Dementia: The Leisure World Cohort Study

(2012) Annlia Paganini-Hill et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation

(2011) Bo Cui et al.   BRAIN RESEARCH

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Sedentary Behavior: Emerging Evidence for a New Health Risk

(2010) Neville Owen et al.   MAYO CLINIC PROCEEDINGS

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Noise and Quality of Life

(2010) Michael D. Seidman et al.   International Journal of Environmental Research and Public Health

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

(2009) D Mariat et al.   BMC MICROBIOLOGY

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Oral Biofilms: Emerging Concepts in Microbial Ecology

(2009) S. Filoche et al.   JOURNAL OF DENTAL RESEARCH

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of Chronic Noise Exposure on Spatial Learning and Memory of Rats in Relation to Neurotransmitters and NMDAR2B Alteration in the Hippocampus

(2009) Bo Cui et al.   JOURNAL OF OCCUPATIONAL HEALTH

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP × PS1 knock-in mice

(2008) Christa M. Studzinski et al.   JOURNAL OF NEUROCHEMISTRY

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

(2008) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Inflammation and Alzheimer's disease: Possible role of periodontal diseases

(2007) Angela R. Kamer et al.   Alzheimers & Dementia