Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

(2012) Yoshiko Shimamura et al.   Clinical and Experimental Nephrology

Identification of novel small molecules that elevate Klotho expression

(2011) Gwendalyn D. King et al.   BIOCHEMICAL JOURNAL

TRPC Channels As Effectors of Cardiac Hypertrophy

(2011) Petra Eder et al.   CIRCULATION RESEARCH

KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer

(2011) L. Abramovitz et al.   CLINICAL CANCER RESEARCH

WNK1 Promotes PIP2 Synthesis to Coordinate Growth Factor and GPCR-Gq Signaling

(2011) Sung-Wan An et al.   CURRENT BIOLOGY

Vesicle-associated Membrane Protein-2 (VAMP2) Mediates cAMP-stimulated Renin Release in Mouse Juxtaglomerular Cells

(2011) Mariela Mendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiomyocyte calcineurin signaling in subcellular domains: From the sarcolemma to the nucleus and beyond

(2011) Joerg Heineke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TRPC6 Enhances Angiotensin II-induced Albuminuria

(2011) J. Eckel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

(2010) Yuji Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

Hypertension, left ventricular hypertrophy and chronic kidney disease

(2010) Stefano Taddei et al.   HEART FAILURE REVIEWS

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models

(2010) Zhen Liu et al.   HUMAN MOLECULAR GENETICS

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRPC channels are necessary mediators of pathologic cardiac hypertrophy

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRP-ing up Heart and Vessels: Canonical Transient Receptor Potential Channels and Cardiovascular Disease

(2010) Janelle Rowell et al.   Journal of Cardiovascular Translational Research

Left Ventricular Mass in Chronic Kidney Disease and ESRD

(2009) R. J. Glassock et al.   Clinical Journal of the American Society of Nephrology

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation

(2009) Norimichi Koitabashi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

(2008) Teruyo Nakatani et al.   FASEB JOURNAL

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

(2008) S.-K. Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA