The rise and rise of mitochondrial DNA mutations

Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis

(2019) Lawrence M. Schwartz   Frontiers in Physiology

Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions

(2019) Örjan Persson et al.   Nature Communications

Mechanisms of Mitochondrial DNA Deletion Formation

(2019) Nadee Nissanka et al.   TRENDS IN GENETICS

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

(2019) Leif S. Ludwig et al.   CELL

Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level

(2019) Diana Lehmann et al.   NUCLEIC ACIDS RESEARCH

Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues

(2019) Chun Chen et al.   NEUROBIOLOGY OF DISEASE

Pathological mechanisms underlying single large-scale mitochondrial DNA deletions

(2018) Mariana C. Rocha et al.   ANNALS OF NEUROLOGY

Sub-cellular origin of mtDNA deletions in human skeletal muscle

(2018) Amy E Vincent et al.   ANNALS OF NEUROLOGY

mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease

(2018) John P Grady et al.   EMBO Molecular Medicine

Tissue specific differences in mitochondrial DNA maintenance and expression

(2018) Elena Herbers et al.   MITOCHONDRION

Ultradeep mapping of neuronal mitochondrial deletions in Parkinson's disease

(2018) Gonzalo S. Nido et al.   NEUROBIOLOGY OF AGING

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo

(2018) Oliver M. Russell et al.   Scientific Reports

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

(2018) Tianhong Su et al.   Genes

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

(2018) Axel Kowald et al.   Genes

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

(2018) Craig Stamp et al.   EBioMedicine

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals

(2018) Lakshmi Narayanan Lakshmanan et al.   AGING CELL

Stan: A Probabilistic Programming Language

(2017) Bob Carpenter et al.   Journal of Statistical Software

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

(2017) Mohammad Moad et al.   Cell Reports

Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations

(2016) Iain G. Johnston et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

(2016) Bryan L. Gitschlag et al.   Cell Metabolism

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

(2016) Thomas G. McWilliams et al.   JOURNAL OF CELL BIOLOGY

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis

(2016) Karolina A. Rygiel et al.   NUCLEIC ACIDS RESEARCH

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

(2015) Prashant Mishra et al.   Cell Metabolism

Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle

(2014) G. Campbell et al.   HUMAN MOLECULAR GENETICS

Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling

(2014) Verónica Eisner et al.   JOURNAL OF CELL BIOLOGY

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

(2014) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

(2013) Holly L. Baines et al.   AGING CELL

MitoBreak: the mitochondrial DNA breakpoints database

(2013) Joana Damas et al.   NUCLEIC ACIDS RESEARCH

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animals

(2012) Michael F. N. O′Leary et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

(2012) Raymond G. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study

(2012) Martin Picard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Clinical features and heteroplasmy in blood, urine and saliva in 34 Dutch families carrying the m.3243A > G mutation

(2012) Paul de Laat et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells

(2011) John K Blackwood et al.   JOURNAL OF PATHOLOGY

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Bayesian parameter inference for stochastic biochemical network models using particle Markov chain Monte Carlo

(2011) A. Golightly et al.   Interface Focus

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

(2010) Laura C. Greaves et al.   EXPERIMENTAL GERONTOLOGY

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions

(2010) Paula M Keeney et al.   Molecular Neurodegeneration

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

(2009) Marco Nooteboom et al.   AGING CELL

Bayesian Emulation and Calibration of a Stochastic Computer Model of Mitochondrial DNA Deletions in Substantia Nigra Neurons

(2009) Daniel A. Henderson et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Stochastic modelling for quantitative description of heterogeneous biological systems

(2009) Darren J. Wilkinson   NATURE REVIEWS GENETICS

A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues

(2009) Tariq G. Fellous et al.   STEM CELLS

Nature of Mitochondrial DNA Deletions in Substantia Nigra Neurons

(2008) Amy K. Reeve et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

(2008) Hirokazu Fukui et al.   HUMAN MOLECULAR GENETICS

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

(2008) A. Bender et al.   JOURNAL OF NEUROLOGY

Mitochondrial Membrane Potential in Axons Increases with Local Nerve Growth Factor or Semaphorin Signaling

(2008) J. Verburg et al.   JOURNAL OF NEUROSCIENCE

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

(2007) Stuart A.C. McDonald et al.   GASTROENTEROLOGY