Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals

Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

(2016) Allen Herbst et al.   AGING CELL

Caenorhabditis elegans: What We Can and Cannot Learn from Aging Worms

(2015) Jan Gruber et al.   ANTIOXIDANTS & REDOX SIGNALING

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?

(2015) Lakshmi Narayanan Lakshmanan et al.   NUCLEIC ACIDS RESEARCH

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations

(2015) Zhi Yang Tam et al.   PLoS Computational Biology

Effects of 5′-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans

(2014) J.P. Rooney et al.   EXPERIMENTAL GERONTOLOGY

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

(2014) Li Fang Ng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals

(2013) Axel Kowald et al.   AGING CELL

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

(2013) Holly L. Baines et al.   AGING CELL

Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans

(2013) Bedoor Qabazard et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial mutations and ageing: Can mitochondrial deletion mutants accumulate via a size based replication advantage?

(2013) Axel Kowald et al.   JOURNAL OF THEORETICAL BIOLOGY

Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

(2013) Zhi Yang Tam et al.   PLoS One

Is mitochondrial DNA turnover slower than commonly assumed?

(2012) Suresh Kumar Poovathingal et al.   BIOGERONTOLOGY

Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

(2012) Amanda S. Bess et al.   NUCLEIC ACIDS RESEARCH

Role of Direct Repeat and Stem-Loop Motifs in mtDNA Deletions: Cause or Coincidence?

(2012) Lakshmi Narayanan Lakshmanan et al.   PLoS One

Mitochondrial Changes in Ageing Caenorhabditis elegans – What Do We Learn from Superoxide Dismutase Knockouts?

(2011) Jan Gruber et al.   PLoS One

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

The effect of dichloroacetate on health- and lifespan in C. elegans

(2010) S. Schaffer et al.   BIOGERONTOLOGY

The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers

(2010) Siôn L. Williams et al.   Cell Metabolism

QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology

(2010) Joel N. Meyer   ECOTOXICOLOGY

Decline in oxygen consumption correlates with lifespan in long-lived and short-lived mutants of Caenorhabditis elegans

(2009) Tetsuji Shoyama et al.   EXPERIMENTAL GERONTOLOGY

On the timing and the extent of clonal expansion of mtDNA deletions: Evidence from single-molecule PCR

(2009) Alexander Nicholas et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development

(2009) Ivana Bratic et al.   NUCLEIC ACIDS RESEARCH

Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico

(2009) Suresh Kumar Poovathingal et al.   PLoS Computational Biology

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS