Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble

(2017) Vasilis Kontis et al.   LANCET

Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

(2016) Allen Herbst et al.   AGING CELL

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

(2016) Bryan L. Gitschlag et al.   Cell Metabolism

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

(2016) Nikolay P. Kandul et al.   Nature Communications

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations

(2015) Zhi Yang Tam et al.   PLoS Computational Biology

When man got his mtDNA deletions?

(2014) Konstantin Popadin et al.   AGING CELL

Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle

(2014) G. Campbell et al.   HUMAN MOLECULAR GENETICS

The road to rack and ruin: selecting deleterious mitochondrial DNA variants

(2014) I. J. Holt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

(2014) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals

(2013) Axel Kowald et al.   AGING CELL

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation

(2013) Ying Dai et al.   HUMAN MOLECULAR GENETICS

Mitochondrial mutations and ageing: Can mitochondrial deletion mutants accumulate via a size based replication advantage?

(2013) Axel Kowald et al.   JOURNAL OF THEORETICAL BIOLOGY

MitoBreak: the mitochondrial DNA breakpoints database

(2013) Joana Damas et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Inverted Repeats Strongly Correlate with Lifespan: mtDNA Inversions and Aging

(2013) Jiang-Nan Yang et al.   PLoS One

Role of Direct Repeat and Stem-Loop Motifs in mtDNA Deletions: Cause or Coincidence?

(2012) Lakshmi Narayanan Lakshmanan et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Differences in the accumulation of mitochondrial defects with age in mice and humans

(2011) Laura C. Greaves et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The timing of mitochondrial DNA mutations in aging

(2011) Konstantin Khrapko   NATURE GENETICS

Evolution of the mitochondrial fusion-fission cycle and its role in aging

(2011) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

(2010) Insil Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeats, longevity and the sources of mtDNA deletions: evidence from ‘deletional spectra’

(2010) Xinhong Guo et al.   TRENDS IN GENETICS

Frequency and Selectivity of Mitochondrial Fusion Are Key to Its Quality Maintenance Function

(2009) Pradeep K. Mouli et al.   BIOPHYSICAL JOURNAL

On the timing and the extent of clonal expansion of mtDNA deletions: Evidence from single-molecule PCR

(2009) Alexander Nicholas et al.   EXPERIMENTAL NEUROLOGY

Nature of Mitochondrial DNA Deletions in Substantia Nigra Neurons

(2008) Amy K. Reeve et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

(2008) Hirokazu Fukui et al.   HUMAN MOLECULAR GENETICS