Translating insights from neuropsychiatric genetics and genomics for precision psychiatry
出版年份 2020 全文链接
标题
Translating insights from neuropsychiatric genetics and genomics for precision psychiatry
作者
关键词
-
出版物
Genome Medicine
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-04-29
DOI
10.1186/s13073-020-00734-5
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
- (2020) F. Kyle Satterstrom et al. CELL
- SPECC1L regulates palate development downstream of IRF6
- (2020) Everett G Hall et al. HUMAN MOLECULAR GENETICS
- Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations
- (2020) Daniel P. Howrigan et al. NATURE NEUROSCIENCE
- De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia
- (2020) Elliott Rees et al. NATURE NEUROSCIENCE
- A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia
- (2019) Sophie E. Legge et al. MOLECULAR PSYCHIATRY
- Commercial Pharmacogenetic Tests in Psychiatry: Do they Facilitate the Implementation of Pharmacogenetic Dosing Guidelines?
- (2019) Mikayla Fan et al. PHARMACOPSYCHIATRY
- Molecular subtypes of pancreatic cancer
- (2019) Eric A. Collisson et al. Nature Reviews Gastroenterology & Hepatology
- Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- (2019) Laura M. Huckins et al. NATURE GENETICS
- Clinical use of current polygenic risk scores may exacerbate health disparities
- (2019) Alicia R. Martin et al. NATURE GENETICS
- Identification of common genetic risk variants for autism spectrum disorder
- (2019) Jakob Grove et al. NATURE GENETICS
- Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank
- (2019) Anthony Warland et al. MOLECULAR PSYCHIATRY
- Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders
- (2019) Patrick F. Sullivan et al. CELL
- Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism
- (2019) Antonio F. Pardiñas et al. AMERICAN JOURNAL OF PSYCHIATRY
- Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies
- (2019) Dongmei Yu et al. AMERICAN JOURNAL OF PSYCHIATRY
- Complex Trait Prediction from Genome Data: Contrasting EBV in Livestock to PRS in Humans
- (2019) Naomi R. Wray et al. GENETICS
- Genome-wide association study identifies 30 loci associated with bipolar disorder
- (2019) Eli A. Stahl et al. NATURE GENETICS
- Single-cell genomics identifies cell type–specific molecular changes in autism
- (2019) Dmitry Velmeshev et al. SCIENCE
- Modeling neuropsychiatric disorders using human induced pluripotent stem cells
- (2019) Meiyan Wang et al. Protein & Cell
- CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks
- (2019) Eric Deneault et al. eLife
- Association of Rare Copy Number Variants With Risk of Depression
- (2019) Kimberley Marie Kendall et al. JAMA Psychiatry
- Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders
- (2019) Siddharth Srivastava et al. GENETICS IN MEDICINE
- GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores
- (2019) Niamh Mullins et al. AMERICAN JOURNAL OF PSYCHIATRY
- Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems
- (2019) Amanda B. Zheutlin et al. AMERICAN JOURNAL OF PSYCHIATRY
- A global overview of pleiotropy and genetic architecture in complex traits
- (2019) Kyoko Watanabe et al. NATURE GENETICS
- A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity
- (2019) Vahid H. Gazestani et al. NATURE NEUROSCIENCE
- Non-Genetic Factors in Schizophrenia
- (2019) Simona A. Stilo et al. Current Psychiatry Reports
- CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
- (2019) Gabriel E. Hoffman et al. Scientific Data
- Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk
- (2019) Diana O. Perkins et al. AMERICAN JOURNAL OF PSYCHIATRY
- Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- (2019) Phil H. Lee et al. CELL
- Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register
- (2018) Rikke Hilker et al. BIOLOGICAL PSYCHIATRY
- Can Animal Models of Copy Number Variants that Predispose to Schizophrenia Elucidate Underlying Biology?
- (2018) Annika Forsingdal et al. BIOLOGICAL PSYCHIATRY
- Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome
- (2018) Adam C. Cunningham et al. BRITISH JOURNAL OF PSYCHIATRY
- Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model
- (2018) Naomi R. Wray et al. CELL
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
- (2018) Naomi R. Wray et al. NATURE GENETICS
- Genetic identification of brain cell types underlying schizophrenia
- (2018) Nathan G. Skene et al. NATURE GENETICS
- Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
- (2018) Antonio F. Pardiñas et al. NATURE GENETICS
- Analysis of shared heritability in common disorders of the brain
- (2018) et al. SCIENCE
- The conception of the ABCD study: From substance use to a broad NIH collaboration
- (2018) Nora D. Volkow et al. Developmental Cognitive Neuroscience
- Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
- (2018) Krishna C. Vadodaria et al. Genome Medicine
- Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
- (2018) Mari E. K. Niemi et al. NATURE
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
- (2018) Amit V. Khera et al. NATURE GENETICS
- De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis
- (2018) Sheng Wang et al. Cell Reports
- Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia
- (2018) Sarah E. Bergen et al. AMERICAN JOURNAL OF PSYCHIATRY
- Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis
- (2018) Jian-Ping Zhang et al. AMERICAN JOURNAL OF PSYCHIATRY
- Developmental Contributions of Schizophrenia Risk Alleles and Childhood Peer Victimization to Early-Onset Mental Health Trajectories
- (2018) Lucy Riglin et al. AMERICAN JOURNAL OF PSYCHIATRY
- Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis
- (2018) Elliott Rees et al. BIOLOGICAL PSYCHIATRY
- Predicting polygenic risk of psychiatric disorders
- (2018) Alicia R. Martin et al. BIOLOGICAL PSYCHIATRY
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
- (2018) Ditte Demontis et al. NATURE GENETICS
- Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity
- (2018) Bradley P. Coe et al. NATURE GENETICS
- Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder
- (2018) Nenad Sestan et al. NEURON
- Stem cell models of schizophrenia, what have we learned and what is the potential?
- (2018) Mohsen Moslem et al. SCHIZOPHRENIA RESEARCH
- Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
- (2018) Michael J. Gandal et al. SCIENCE
- Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood
- (2018) Sumit Mistry et al. JOURNAL OF AFFECTIVE DISORDERS
- Collider scope: when selection bias can substantially influence observed associations
- (2017) Marcus R Munafò et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
- (2017) D P Hibar et al. MOLECULAR PSYCHIATRY
- Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
- (2017) Paul D Arnold et al. MOLECULAR PSYCHIATRY
- The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
- (2017) Tarjinder Singh et al. NATURE GENETICS
- Truncating mutations in RBM12 are associated with psychosis
- (2017) Stacy Steinberg et al. NATURE GENETICS
- Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
- (2017) Daniel J Weiner et al. NATURE GENETICS
- Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
- (2017) Hon-Cheong So et al. NATURE NEUROSCIENCE
- Whole genome sequencing in psychiatric disorders: the WGSPD consortium
- (2017) Stephan J. Sanders et al. NATURE NEUROSCIENCE
- The use of brain organoids to investigate neural development and disease
- (2017) Elizabeth Di Lullo et al. NATURE REVIEWS NEUROSCIENCE
- Integration of optogenetics with complementary methodologies in systems neuroscience
- (2017) Christina K. Kim et al. NATURE REVIEWS NEUROSCIENCE
- Schizophrenia and the neurodevelopmental continuum:evidence from genomics
- (2017) Michael J. Owen et al. World Psychiatry
- Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
- (2017) Lavinia Paternoster et al. PLoS Genetics
- Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function
- (2017) Olav B. Smeland et al. JAMA Psychiatry
- Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia
- (2017) Joey Ward et al. Translational Psychiatry
- Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
- (2016) S E Legge et al. MOLECULAR PSYCHIATRY
- Analysis of protein-coding genetic variation in 60,706 humans
- (2016) Monkol Lek et al. NATURE
- Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
- (2016) Christian R Marshall et al. NATURE GENETICS
- The implications of the shared genetics of psychiatric disorders
- (2016) Michael C O'Donovan et al. NATURE MEDICINE
- The promises and challenges of human brain organoids as models of neuropsychiatric disease
- (2016) Giorgia Quadrato et al. NATURE MEDICINE
- Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders
- (2016) Tarjinder Singh et al. NATURE NEUROSCIENCE
- Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
- (2016) Andrea Ganna et al. NATURE NEUROSCIENCE
- Gene expression elucidates functional impact of polygenic risk for schizophrenia
- (2016) Menachem Fromer et al. NATURE NEUROSCIENCE
- Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
- (2016) Giulio Genovese et al. NATURE NEUROSCIENCE
- Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia
- (2016) Elliott Rees et al. JAMA Psychiatry
- Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes
- (2016) Waseem K. Raja et al. PLoS One
- Prostate cancer screening in men aged 50–69 years (STHLM3): a prospective population-based diagnostic study
- (2015) Henrik Grönberg et al. LANCET ONCOLOGY
- Common alleles contribute to schizophrenia in CNV carriers
- (2015) K E Tansey et al. MOLECULAR PSYCHIATRY
- Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic
- (2015) T Lencz et al. MOLECULAR PSYCHIATRY
- Copy number variation in bipolar disorder
- (2015) E K Green et al. MOLECULAR PSYCHIATRY
- The PsychENCODE project
- (2015) Schahram Akbarian et al. NATURE NEUROSCIENCE
- Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci
- (2015) Stephan J. Sanders et al. NEURON
- The relative contribution of common and rare genetic variants to ADHD
- (2015) J Martin et al. Translational Psychiatry
- Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study
- (2014) Lauren M. McGrath et al. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
- De novo mutations in schizophrenia implicate synaptic networks
- (2014) Menachem Fromer et al. NATURE
- Refining analyses of copy number variation identifies specific genes associated with developmental delay
- (2014) Bradley P Coe et al. NATURE GENETICS
- New Approaches to Psychiatric Diagnostic Classification
- (2014) Michael J. Owen NEURON
- Translating intermediate phenotypes to psychopathology: The NIMH Research Domain Criteria
- (2014) Bruce N. Cuthbert PSYCHOPHYSIOLOGY
- Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease
- (2014) Jonathan Flint et al. TRENDS IN NEUROSCIENCES
- The Penetrance of Copy Number Variations for Schizophrenia and Developmental Delay
- (2013) George Kirov et al. BIOLOGICAL PSYCHIATRY
- Analysis of copy number variations at 15 schizophrenia-associated loci
- (2013) Elliott Rees et al. BRITISH JOURNAL OF PSYCHIATRY
- Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
- (2013) LANCET
- The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
- (2013) Danielle Welter et al. NUCLEIC ACIDS RESEARCH
- Pharmacogenomics Knowledge for Personalized Medicine
- (2012) M Whirl-Carrillo et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
- (2012) S Hong Lee et al. NATURE GENETICS
- Genetic architectures of psychiatric disorders: the emerging picture and its implications
- (2012) Patrick F. Sullivan et al. NATURE REVIEWS GENETICS
- De Novo Rates and Selection of Schizophrenia-Associated Copy Number Variants
- (2011) Elliott Rees et al. BIOLOGICAL PSYCHIATRY
- De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
- (2011) G Kirov et al. MOLECULAR PSYCHIATRY
- Using electronic health records to drive discovery in disease genomics
- (2011) Isaac S. Kohane NATURE REVIEWS GENETICS
- Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies
- (2010) David T. Miller et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis
- (2010) Nigel M Williams et al. LANCET
- Animal models of neuropsychiatric disorders
- (2010) Eric J Nestler et al. NATURE NEUROSCIENCE
- DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources
- (2009) Helen V. Firth et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
- (2009) Shaun M. Purcell et al. NATURE
- Neurexin 1 (NRXN1) Deletions in Schizophrenia
- (2009) G. Kirov et al. SCHIZOPHRENIA BULLETIN
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