Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges

Genetic risk variants as therapeutic targets for Crohn’s disease

(2017) Tommaso Gabbani et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

When Will Mendelian Randomization Become Relevant for Clinical Practice and Public Health?

(2017) George Davey Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

(2017) James C Lee et al.   NATURE GENETICS

Association of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study

(2016) Joanna Martin et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

(2016) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

Instrumental Variable Estimation in a Survival Context

(2015) Eric J. Tchetgen Tchetgen et al.   EPIDEMIOLOGY

Mendelian randomization studies: a review of the approaches used and the quality of reporting

(2015) A. G. C. Boef et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A genome-wide association study of body mass index across early life and childhood

(2015) N. M. Warrington et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway

(2014) Bjørn O Åsvold et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomisation applied to drug development in cardiovascular disease: a review

(2014) Lauren E Mokry et al.   JOURNAL OF MEDICAL GENETICS

Robustness of the linear mixed effects model to error distribution assumptions and the consequences for genome-wide association studies

(2014) Nicole M. Warrington et al.   Statistical Applications in Genetics and Molecular Biology

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

(2014) M. V. Holmes et al.   BMJ-British Medical Journal

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

(2012) Marcus R. Munafò et al.   JNCI-Journal of the National Cancer Institute

Progression of lumbar disc degeneration over a decade: a heritability study

(2011) F. M. K. Williams et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies

(2011) Ma'en Obeidat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Type II Secretory Phospholipase A2 and Prognosis in Patients with Stable Coronary Heart Disease: Mendelian Randomization Study

(2011) Lutz P. Breitling et al.   PLoS One

C-Reactive Protein and the Risk of Cancer: A Mendelian Randomization Study

(2010) Kristine H. Allin et al.   JNCI-Journal of the National Cancer Institute

The HapMap and Genome-Wide Association Studies in Diagnosis and Therapy

(2009) Teri A. Manolio et al.   Annual Review of Medicine

Inflammation, Insulin Resistance, and Diabetes—Mendelian Randomization Using CRP Haplotypes Points Upstream

(2008) Eric J Brunner et al.   PLOS MEDICINE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE