Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

(2019) Dhanendra Tomar et al.   Cell Reports

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

(2019) Benjamin Gottschalk et al.   Nature Communications

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

(2018) Raghavendra Sashi Krishna Nagampalli et al.   Scientific Reports

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

(2018) Santhanam Shanmughapriya et al.   Nature Communications

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

SPG7 is an Essential and Conserved Component of the Mitochondrial Permeability transition Pore

(2016) Santhanam Shanmughapriya et al.   BIOPHYSICAL JOURNAL

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

(2016) Benoît Vanderperre et al.   PLoS Genetics

Mitochondrial pyruvate import and its effects on homeostasis

(2015) Benoît Vanderperre et al.   CURRENT OPINION IN CELL BIOLOGY

Atypical Manifestation of Carnitine Palmitoyltransferase 1A Deficiency

(2015) Beom Hee Lee et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

Mitochondrial response to nutrient availability and its role in metabolic disease

(2014) A. W. Gao et al.   EMBO Molecular Medicine

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation

(2014) Patrick J. Doonan et al.   FASEB JOURNAL

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

(2014) John C. Schell et al.   MOLECULAR CELL

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

(2014) Patrick A. Vigueira et al.   Cell Reports

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Hallmarks of a new era in mitochondrial biochemistry

(2013) D. J. Pagliarini et al.   GENES & DEVELOPMENT

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Common Pathway for a Rare Disease?

(2013) S. B. Vafai et al.   SCIENCE

Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart

(2013) R. J. Vagnozzi et al.   Science Translational Medicine

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor

(2011) Yin Pun Hung et al.   Cell Metabolism

Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis

(2011) K. M. Irrinki et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Endoplasmic reticulum: nutrient sensor in physiology and pathology

(2009) József Mandl et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diseases caused by defects of mitochondrial carriers: A review

(2008) Ferdinando Palmieri   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats

(2008) J. C. Gonzales et al.   DIABETOLOGIA

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE