LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

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SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death

(2014) Nicholas E. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

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Functional reconstitution of the mitochondrial Ca2+/H+antiporter Letm1

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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

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Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome

(2013) D. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart

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MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

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MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

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Mitochondria take center stage

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The Pathophysiology of LETM1

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The renaissance of mitochondrial pH

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CaMKII determines mitochondrial stress responses in heart

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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Erratum: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Activity of the mitochondrial calcium uniporter varies greatly between tissues

(2012) Francesca Fieni et al.   Nature Communications

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Leucine Zipper EF Hand-containing Transmembrane Protein 1 (Letm1) and Uncoupling Proteins 2 and 3 (UCP2/3) Contribute to Two Distinct Mitochondrial Ca2+Uptake Pathways

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Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

The Cardiac Mitochondrion: Nexus of Stress

(2010) Christopher P. Baines   Annual Review of Physiology

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

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Mitochondrial Complex II Prevents Hypoxic but Not Calcium- and Proapoptotic Bcl-2 Protein-induced Mitochondrial Membrane Potential Loss

(2010) Brian J. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

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A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome

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Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak

(2009) M. Madesh et al.   MOLECULAR AND CELLULAR BIOLOGY

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L

(2008) S. Tamai et al.   JOURNAL OF CELL SCIENCE