Gelsemine, a natural alkaloid extracted from Gelsemium elegans Benth. alleviates neuroinflammation and cognitive impairments in Aβ oligomer-treated mice

Gelsemine and koumine, principal active ingredients of Gelsemium, exhibit mechanical antiallodynia via spinal glycine receptor activation-induced allopregnanolone biosynthesis

(2019) Rana Muhammad Shoaib et al.   BIOCHEMICAL PHARMACOLOGY

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content

(2018) Yuanyuan Wang et al.   METABOLIC BRAIN DISEASE

Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer’s Disease

(2018) Jinze Li et al.   Frontiers in Aging Neuroscience

Soluble Aβ1–42 increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing

(2018) Daehun Park et al.   Molecular Brain

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in mice

(2018) Hui-Qin Li et al.   Chinese Medicine

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

(2018) Huang Chunhui et al.   Jove-Journal of Visualized Experiments

Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation

(2018) Yan-Fang Xian et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective effect of mogrol against Aβ1-42 -induced memory impairment neuroinflammation and apoptosis in mice

(2018) Gangling Chen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Uncaria rhynchophylla ameliorates amyloid beta deposition and amyloid beta-mediated pathology in 5XFAD mice

(2018) Soo Jung Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer’s Disease

(2017) Xin-jun Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

(2017) Jade Marsh et al.   NEUROBIOLOGY OF DISEASE

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

Amyloid-β Induces Caspase-Dependent Loss of PSD-95 and Synaptophysin Through NMDA Receptors

(2017) Jinping Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice

(2016) Ling Huang et al.   ACS Chemical Neuroscience

Functional modulation of glycine receptors by the alkaloid gelsemine

(2016) Cesar O Lara et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer’s Disease

(2016) Ingrid H. Philippens et al.   JOURNAL OF ALZHEIMERS DISEASE

Ginsenosides attenuate d-galactose- and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer's disease

(2016) Yan Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Alzheimer’s disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior

(2016) Sheetal Sharma et al.   NEUROLOGICAL RESEARCH

Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice

(2015) Yu-er Wu et al.   ACTA PHARMACOLOGICA SINICA

Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits

(2015) Shu-Sheng Jiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

(2015) Lan Chang et al.   Scientific Reports

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological effect of gelsemine on anxiety-like behavior in rat

(2013) Laurence Meyer et al.   BEHAVIOURAL BRAIN RESEARCH

New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease

(2013) Miguel Medina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer’s Disease

(2012) S. Duke Han et al.   Brain Imaging and Behavior

Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone

(2012) Ying Xu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics

(2012) Ming Liu et al.   PSYCHOPHARMACOLOGY

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

Antitumor activity of two gelsemine metabolites in rat liver microsomes

(2010) Qing-Chun Zhao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE