Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation
出版年份 2017 全文链接
标题
Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation
作者
关键词
Familial Alzheimer’s disease, Sporadic Alzheimer’s disease, Induced pluripotent stem cells, Amyloid β, TAU pathology, Hyperphosphorylation, GSK3B
出版物
Alzheimers Research & Therapy
Volume 9, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-11-17
DOI
10.1186/s13195-017-0317-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
- (2017) Eric Tönnies et al. JOURNAL OF ALZHEIMERS DISEASE
- Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation
- (2017) Masato Hosokawa et al. Scientific Reports
- Alzheimer's Disease and the Amyloid-β Peptide
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Establishment of PSEN1 mutant induced pluripotent stem cell (iPSC) line from an Alzheimer's disease (AD) female patient
- (2016) Csilla Nemes et al. Stem Cell Research
- Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD)
- (2016) Abinaya Chandrasekaran et al. Stem Cell Research
- Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease
- (2016) Anna Ochalek et al. Stem Cell Research
- Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD)
- (2016) Zsuzsanna Táncos et al. Stem Cell Research
- Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD)
- (2016) Zsuzsanna Táncos et al. Stem Cell Research
- Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1
- (2016) Alisa Tubsuwan et al. Stem Cell Research
- Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks
- (2015) Amir M Hossini et al. BMC GENOMICS
- Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology
- (2015) Sue Richards et al. GENETICS IN MEDICINE
- Progranulin Reduction Is Associated With Increased Tau Phosphorylation in P301L Tau Transgenic Mice
- (2015) Masato Hosokawa et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Frontotemporal dementia
- (2015) Jee Bang et al. LANCET
- Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR
- (2015) Hui Yang et al. Nature Protocols
- The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
- (2014) Christina R. Muratore et al. HUMAN MOLECULAR GENETICS
- Small Aβ1-42oligomer-induced membrane depolarization of neuronal and microglial cells: Role of N-methyl-D-aspartate receptors
- (2014) Ramune Morkuniene et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors
- (2014) Andrew A. Sproul et al. PLoS One
- The therapeutics of Alzheimer's disease: Where we stand and where we are heading
- (2013) Dennis J. Selkoe ANNALS OF NEUROLOGY
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
- (2013) Takayuki Kondo et al. Cell Stem Cell
- Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation
- (2013) MIZUKI TOCHIGI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils
- (2013) Lei Gu et al. JOURNAL OF NEUROCHEMISTRY
- GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo
- (2013) M Llorens-Martín et al. MOLECULAR PSYCHIATRY
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3
- (2013) Yulei Deng et al. NEUROBIOLOGY OF AGING
- A induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
- (2013) M. Talantova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening
- (2013) C Boissart et al. Translational Psychiatry
- wANNOVAR: annotating genetic variants for personal genomes via the web
- (2012) Xiao Chang et al. JOURNAL OF MEDICAL GENETICS
- Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation
- (2011) Lujia Zhou et al. EMBO Molecular Medicine
- Hydrogen peroxide induces neurite degeneration: Prevention by tocotrienols
- (2011) Koji Fukui et al. FREE RADICAL RESEARCH
- Modeling familial Alzheimer's disease with induced pluripotent stem cells
- (2011) Takuya Yagi et al. HUMAN MOLECULAR GENETICS
- Soluble A Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors
- (2011) S. Li et al. JOURNAL OF NEUROSCIENCE
- Different Susceptibility to Neurodegeneration of Dorsal and Ventral Hippocampal Dentate Gyrus: A Study with Transgenic Mice Overexpressing GSK3β
- (2011) Almudena Fuster-Matanzo et al. PLoS One
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- A Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
- (2010) H. Zempel et al. JOURNAL OF NEUROSCIENCE
- Redox agents modulate neuronal activity and reproduce physiological aspects of neuronal aging
- (2010) Shawn N. Watson et al. NEUROBIOLOGY OF AGING
- Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons
- (2010) Xinglong Wang et al. Neurodegenerative Diseases
- Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
- (2010) Bart De Strooper PHYSIOLOGICAL REVIEWS
- The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells
- (2009) Kazuchika Nishitsuji et al. AMERICAN JOURNAL OF PATHOLOGY
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
- (2009) Bayani Uttara et al. Current Neuropharmacology
- Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease
- (2009) A. Auffret et al. JOURNAL OF NEUROSCIENCE
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- Controlled in situ preparation of Aβ(1–42) oligomers from the isopeptide “iso-Aβ(1–42)”, physicochemical and biological characterization
- (2009) Zsolt Bozso et al. PEPTIDES
- Interprotofilament interactions between Alzheimer's A 1-42 peptides in amyloid fibrils revealed by cryoEM
- (2009) R. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures
- (2009) M. Schmidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity
- (2008) Nichole E. LaPointe et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Amyloid- overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
- (2008) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3
- (2007) Seong-Ho Koh et al. BRAIN RESEARCH
- Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1
- (2007) I. Dewachter et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started