In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
出版年份 2020 全文链接
标题
In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 15, Pages 8486-8493
出版商
Proceedings of the National Academy of Sciences
发表日期
2020-04-01
DOI
10.1073/pnas.1913242117
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM
- (2019) Jessica B. Casaletto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The current state and future directions of RNAi-based therapeutics
- (2019) Ryan L. Setten et al. NATURE REVIEWS DRUG DISCOVERY
- Combined Computational-Experimental Approach to Explore Molecular Mechanism of SaCas9 with Broadened DNA Targeting Range
- (2019) Binquan Luan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- In silico designed RNA aptamer against epithelial cell adhesion molecule for cancer cell imaging
- (2019) Rohit Bavi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Detailed Analysis of 17β-Estradiol-Aptamer Interactions: A Molecular Dynamics Simulation Study
- (2018) Alexander Eisold et al. MOLECULES
- T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable
- (2018) Alok V. Joglekar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Insights into the Osteopontin-Aptamer Complex by Molecular Dynamics Simulations
- (2018) Giovanni La Penna et al. Frontiers in Chemistry
- Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9
- (2018) Serena H. Chen et al. Nanoscale
- EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion
- (2018) Aljaž Gaber et al. Scientific Reports
- HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy
- (2017) Yumeng Yan et al. NUCLEIC ACIDS RESEARCH
- RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme
- (2017) Zhichao Miao et al. RNA
- Unraveling Mg 2+ –RNA binding with atomistic molecular dynamics
- (2017) Richard A. Cunha et al. RNA
- Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
- (2017) Diego Chowell et al. SCIENCE
- Selection and targeting of EpCAM protein by ssDNA aptamer
- (2017) Walhan Alshaer et al. PLoS One
- Capturing RNA Folding Free Energy with Coarse-Grained Molecular Dynamics Simulations
- (2017) David R. Bell et al. Scientific Reports
- Improved Accuracy in RNA–Protein Rigid Body Docking by Incorporating Force Field for Molecular Dynamics Simulation into the Scoring Function
- (2016) Junichi Iwakiri et al. Journal of Chemical Theory and Computation
- Aptamers as targeted therapeutics: current potential and challenges
- (2016) Jiehua Zhou et al. NATURE REVIEWS DRUG DISCOVERY
- Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro
- (2015) Andreas Seeber et al. BMC CANCER
- Magnesium-binding architectures in RNA crystal structures: validation, binding preferences, classification and motif detection
- (2015) Heping Zheng et al. NUCLEIC ACIDS RESEARCH
- Comprehensive analysis of sequences of a protein switch
- (2015) Szu-Hua Chen et al. PROTEIN SCIENCE
- Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors
- (2015) Dongxi Xiang et al. Theranostics
- The energy landscape of a protein switch
- (2014) Szu-Hua Chen et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Crystal structure and its bearing towards an understanding of key biological functions of EpCAM
- (2014) Miha Pavšič et al. Nature Communications
- The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function
- (2014) Zhen Xia et al. Scientific Reports
- Molecular Mechanisms of RNA Interference
- (2013) Ross C. Wilson et al. Annual Review of Biophysics
- Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy
- (2013) Manuel Simon et al. Expert Opinion on Drug Delivery
- DOT2: Macromolecular docking with improved biophysical models
- (2013) Victoria A. Roberts et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- The Use of Sensitive Chemical Antibodies for Diagnosis: Detection of Low Levels of Epcam in Breast Cancer
- (2013) Sarah Shigdar et al. PLoS One
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
- (2012) Robert B. Best et al. Journal of Chemical Theory and Computation
- EpCAM and its potential role in tumor-initiating cells
- (2012) Sannia Imrich et al. Cell Adhesion & Migration
- Expression, crystallization and preliminary X-ray characterization of the human epithelial cell-adhesion molecule ectodomain
- (2011) Miha Pavšič et al. Acta Crystallographica Section F-Structural Biology and Crystallization Communications
- RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
- (2011) Sarah Shigdar et al. CANCER SCIENCE
- Computational approaches to RNA structure prediction, analysis, and design
- (2011) Christian Laing et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110
- (2011) Silke Petsch et al. mAbs
- The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
- (2010) Markus M. Heiss et al. INTERNATIONAL JOURNAL OF CANCER
- Aptamers as therapeutics
- (2010) Anthony D. Keefe et al. NATURE REVIEWS DRUG DISCOVERY
- Computational generation and screening of RNA motifs in large nucleotide sequence pools
- (2010) Namhee Kim et al. NUCLEIC ACIDS RESEARCH
- Origins and Mechanisms of miRNAs and siRNAs
- (2009) Richard W. Carthew et al. CELL
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