Article
Immunology
Lisa Kornstaedt, Sandra Pierre, Andreas Weigert, Stefanie Ebersberger, Tim J. Schaeufele, Anja Kolbinger, Tobias Schmid, Jennifer Cohnen, Dominique Thomas, Nerea Ferreiros, Bernhard Bruene, Ingo Ebersberger, Klaus Scholich
Summary: Mast cells play a role in the resolution phase of inflammation by producing mediators like IFN-beta that regulate macrophage phagocytosis. Deficiency in mast cells can result in decreased efferocytosis and phagocytosis during the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gaetan Barbet, Priyanka Nair-Gupta, Michael Schotsaert, Stephen T. Yeung, Julien Moretti, Fabian Seyffer, Giorgi Metreveli, Thomas Gardner, Angela Choi, Domenico Tortorella, Robert Tampe, Kamal M. Khanna, Adolfo Garcia-Sastre, J. Magarian Blander
Summary: The study explains how viruses target host cell antigen-processing pathways, focusing on MHC-I molecules and the re-routing of ERGIC-resident MHC molecules to phagosomal vesicles for cross-presentation. It suggests that even without TAP, protective CD8(+) T cells can still be mobilized during viral infection, highlighting a noncanonical cross-presentation pathway.
Article
Immunology
Wei Zhang, Eun-Koung An, Juyoung Hwang, Jun-O Jin
Summary: The study found that LPS can directly stimulate pDCs via the TLR4/MD2 pathway and promote the activation of pDCs and cDCs. cDCs may contribute to the enhancement of IFN-alpha production in pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anette Christ, Pieter G. Goossens, Erwin Wijnands, Han Jin, Bart Legein, Tammy Oth, Aaron Isaacs, Monika Stoll, Joris Vanderlocht, Esther Lutgens, Mat J. A. P. Daemen, Martin Zenke, Erik A. L. Biessen
Summary: Hyperlipidemia significantly affects the activation and immune response of pDCs, particularly in response to pathogen-derived signals.
Article
Immunology
Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan
Summary: TLR-containing GM3 liposomes are effective vectors to induce DC maturation and T cell priming. Incorporation of PGPC or MDP does not enhance immune responses. These findings provide guidance for the optimal selection of liposomal components to stimulate anti-cancer immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Johnathan Canton, Hanna Blees, Conor M. Henry, Michael D. Buck, Oliver Schulz, Neil C. Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart, Lucy Collinson, Andres Alloatti, Cara J. Ellison, Sebastian Amigorena, Venizelos Papayannopoulos, David C. Thomas, Felix Randow, Caetano Reis e Sousa
Summary: DNGR-1 is a dedicated cross-presentation receptor that promotes phagosomal rupture, allowing corpse-associated antigens to access the major histocompatibility complex class I antigen processing pathway. This mechanism reveals the existence of innate immune receptors that couple ligand binding and endocytic vesicle damage to regulate adaptive immunity.
Article
Multidisciplinary Sciences
Helene Letscher, Viviane A. Agbogan, Sarantis Korniotis, Pauline Gastineau, Emmanuel Tejerina, Christophe Gras, Jerome Megret, Alison Moe, William R. Drobyski, Flora Zavala
Summary: Early innate education in the bone marrow primes hematopoietic progenitors for trained immunity or immunoregulatory functions. Activation of pDC precursors within the bone marrow can halt progression of autoimmune diseases, offering promising perspectives for cell therapy.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Tingting Zhang, Adila Aipire, Yijie Li, Changying Guo, Jinyao Li
Summary: This review summarizes the mechanisms of cross-presentation (XPT) and its application in tumor immunotherapy. Dendritic cells enhance their antigen presentation capacity through receptor-mediated internalization of exogenous antigens, endosome escape, engagement of other XPT-related proteins, and the use of adjuvants, thereby improving the outcomes of DC-based therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Nicholas J. Shields, Estelle M. Peyroux, Katrin Campbell, Sunali Mehta, Adele G. Woolley, Claudio Counoupas, Silke Neumann, Sarah L. Young
Summary: Proteases released from dying cells can degrade antigens and generate proteolytic intermediates that enhance immune cell responses.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs
Summary: Cholesterol 25-hydroxylase (CH25H) downregulation in dendritic cells (DCs) leads to defective cross-presentation of tumor antigens, resulting in tumor immune evasion and resistance to therapy.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Jamal Hussen, Mayyadah Abdullah Alkuwayti, Baraa Falemban, Mohammed Ali Al-Sukruwah, Sameer M. Alhojaily, Naser Abdallah Al Humam, Salma Al Adwani
Summary: Mastitis is a challenging disease that greatly affects the production and welfare of dairy animals. The study investigated the immunomodulatory effect of selected Toll-like receptor (TLR) ligands on milk immune cells in order to gain a deeper understanding of host-pathogen interactions in the mammary gland. The results may have implications for the development of vaccines against mastitis pathogens.
Article
Biochemistry & Molecular Biology
Lisa G. M. Huis In 't Veld, Nataschja Ho, Melisssa Wassink, Martijn H. den Brok, Gosse J. Adema
Summary: Saponin-based adjuvants (SBAs) are a promising new type of adjuvant that can enhance dendritic cell-mediated antigen cross-presentation and activate CD8 + T cells by inducing lipid bodies. The study reveals that SBAs specifically induce the PERK pathway and depend on its activation for dendritic cell cross-presentation. Additionally, the MHCII(lo)CD11b(hi) subset of dendritic cells shows the highest responsiveness to SBAs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Spencer E. E. Brightman, Angelica Becker, Rukman R. R. Thota, Martin S. S. Naradikian, Leila Chihab, Karla Soria Zavala, Ryan Q. Q. Griswold, Joseph S. S. Dolina, Ezra E. W. Cohen, Aaron M. M. Miller, Bjoern Peters, Stephen P. P. Schoenberger
Summary: CD4(+) T cells have important roles in immune responses, either directly or through accessory cells such as CD8(+) T lymphocytes. While the role of NeoAg-specific CD8(+) T cells in cancer has been extensively studied, the role of NeoAg-specific CD4(+) T cells is less well understood.
Article
Plant Sciences
Shujing Chen, Yun Bai, Yuan Wang, Chunxiao Liang, Kunze Du, Shuangqi Wang, Jin Li, Yan-xu Chang
Summary: The study aimed to clarify the immunosuppressive effect of CBN on the maturation, migration, allogenic T cell stimulation, and phagocytosis capacity of TNF-alpha induced DCs.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck, Karine Breckpot
Summary: The maturation of dendritic cells (DCs) using TriMix mRNA can induce an antibacterial transcriptional program, while the use of TetraMix mRNA can redirect DCs into an antiviral transcriptional program and induce tumor antigen-specific T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Florence Faure, Mabel Jouve, Isabelle Lebhar-Peguillet, Charlotte Sadaka, Fernando Sepulveda, Olivier Lantz, Stefano Berre, Raphael Gaudin, Silvia Sanchez-Ramon, Sebastian Amigorena
INTERNATIONAL JOURNAL OF CANCER
(2018)
Correction
Immunology
Andres Alloatti, Derek C. Rookhuizen, Leonel Joannas, Jean-Marie Carpier, Salvador Iborra, Joao G. Magalhaes, Nader Yatim, Patrycja Kozik, David Sancho, Matthew L. Albert, Sebastian Amigorena
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Immunology
Jean-Marie Carpier, Andres E. Zucchetti, Laurence Bataille, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Sabine Bardin, Marco Lucchino, Mathieu Maurin, Leonel D. Joannas, Joao Gamelas Magalhaes, Ludger Johannes, Thierry Galli, Bruno Goud, Claire Hivroz
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Editorial Material
Immunology
Sebastian Amigorena
JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Luigia Pace, Christel Goudot, Elina Zueva, Paul Gueguen, Nina Burgdorf, Joshua J. Waterfall, Jean-Pierre Quivy, Genevieve Almouzni, Sebastian Amigorena
Article
Multidisciplinary Sciences
Tsing-Lee Tang-Huau, Paul Gueguen, Christel Goudot, Melanie Durand, Mylene Bohec, Sylvain Baulande, Benoit Pasquier, Sebastian Amigorena, Elodie Segura
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Marine Oberkampf, Camille Guillerey, Juliette Mouries, Pierre Rosenbaum, Catherine Fayolle, Alexandre Bobard, Ariel Savina, Eric Ogier-Denis, Jost Enninga, Sebastian Amigorena, Claude Leclerc, Gilles Dadaglio
NATURE COMMUNICATIONS
(2018)
Article
Cell Biology
Patrycja Kozik, Marine Gros, Daniel N. Itzhak, Leonel Joannas, Sandrine Heurtebise-Chretien, Patrycja A. Krawczyk, Pablo Rodriguez-Silvestre, Andres Alloatti, Joao Gamelas Magalhaes, Elaine Del Nery, Georg H. H. Borner, Sebastian Amigorena
Article
Immunology
Johnathan Canton, Hanna Blees, Conor M. Henry, Michael D. Buck, Oliver Schulz, Neil C. Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart, Lucy Collinson, Andres Alloatti, Cara J. Ellison, Sebastian Amigorena, Venizelos Papayannopoulos, David C. Thomas, Felix Randow, Caetano Reis e Sousa
Summary: DNGR-1 is a dedicated cross-presentation receptor that promotes phagosomal rupture, allowing corpse-associated antigens to access the major histocompatibility complex class I antigen processing pathway. This mechanism reveals the existence of innate immune receptors that couple ligand binding and endocytic vesicle damage to regulate adaptive immunity.
Correction
Immunology
Johnathan Canton, Hanna Blees, Conor M. Henry, Michael D. Buck, Oliver Schulz, Neil C. Rogers, Eleanor Childs, Santiago Zelenay, Hefin Rhys, Marie-Charlotte Domart, Lucy Collinson, Andres Alloatti, Cara J. Ellison, Sebastian Amigorena, Venizelos Papayannopoulos, David C. Thomas, Felix Randow, Caetano Sousa
Article
Immunology
Lucia Biscari, Cintia Daniela Kaufman, Cecilia Farre, Victoria Huhn, Maria Florencia Pacini, Camila Bulfoni Balbi, Karina Andrea Gomez, Ana Rosa Perez, Andres Alloatti
Summary: This article presents a vaccination strategy based on dendritic cells (DCs) activated with LPS to enhance CD8(+) T cell responses against specific pathogens. The study found that this immunization scheme provides protection and reduces parasite burden in female mice, but not in male mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Lucia Biscari, Ma Carmen Maza, Cecilia Farre, Cintia Daniela Kaufman, Sebastian Amigorena, Manuel Fresno, Nuria Girones, Andres Alloatti
Summary: Antigen cross-presentation is an essential mechanism for dendritic cells and other antigen-presenting cells to activate CD8(+) T cells and induce cytotoxic responses against infected or cancer cells. The protein Sec22b plays a crucial role in this process by coordinating the recruitment of the transporter associated with antigen processing protein and the peptide loading complex. Silencing Sec22b in dendritic cells impairs antigen cross-presentation and leads to deficient priming of CD8(+) T cells, reduced control of tumor growth, and resistance to anti-checkpoint immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Oncology
Laurent Chene, Caroline Diveu Sader, Joao Magalhaes, Francesco Strozzi, Lorenzo Tibaldi, Celia Mendez, Simon Baeriswyl, Arnaud Laveissiere, Christophe Bonny
Meeting Abstract
Oncology
A. F. Oliveira, L. Bretes, I. Furtado, B. E. Gosalbez Pequeno, J. G. Magalhaes
ANNALS OF ONCOLOGY
(2018)