Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses

(2016) N. Asano et al.   CANCER RESEARCH

MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription

(2016) Yue Li et al.   HEPATOLOGY

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

(2016) Yumi Miyazaki et al.   Molecular Cancer

Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpression

(2015) Ji Hyun Park et al.   BMC CANCER

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

(2015) Kazuhiro Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

(2015) Claudia Allemani et al.   LANCET

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

(2015) Guoxiang Jin et al.   MOLECULAR CELL

Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling

(2015) Diane C. Fingar   MOLECULAR CELL

Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis

(2015) Dazhi Xu et al.   Nature Communications

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

(2014) Janice D. Thomas et al.   CANCER CELL

Targeting mTOR dependency in pancreatic cancer

(2014) Douglas C Morran et al.   GUT

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

(2013) Chia-Hsin Chan et al.   CELL

STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells

(2013) Zheng Wei et al.   CELLULAR SIGNALLING

Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells

(2013) Z. Chang et al.   CLINICAL CANCER RESEARCH

Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study

(2013) Atsushi Ohtsu et al.   JOURNAL OF CLINICAL ONCOLOGY

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex

(2012) J Wu et al.   ONCOGENE

Skp2 is a Promising Therapeutic Target in Breast Cancer

(2012) Zhiwei Wang et al.   Frontiers in Oncology

Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer

(2010) Da-zhi Xu et al.   BMC CANCER

Possible role of EBV in breast cancer and other unusually EBV-associated cancers

(2010) Aurélie Hippocrate et al.   CANCER LETTERS

Regulation of Skp2 Levels by the Pim-1 Protein Kinase

(2010) Bo Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled

(2010) Thorsten Gnad et al.   Molecular Cancer

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

(2010) Chia-Hsin Chan et al.   NATURE CELL BIOLOGY

Relation between outcomes and localisation of p-mTOR expression in gastric cancer

(2009) T Murayama et al.   BRITISH JOURNAL OF CANCER

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase

(2008) Geneviève Rodier et al.   EMBO JOURNAL

Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial

(2008) Kazutoshi Fukase et al.   LANCET

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS