Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin

LncRNA NEAT1/let-7a-5p axis regulates the cisplatin resistance in nasopharyngeal carcinoma by targeting Rsf-1 and modulating the Ras-MAPK pathway

(2018) Fei Liu et al.   CANCER BIOLOGY & THERAPY

Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway

(2018) Wei Li et al.   CELLULAR SIGNALLING

The value of radical radiotherapy in the primary tumor of newly diagnosed oligo-metastatic nasopharyngeal carcinoma patients

(2018) H. Shuang et al.   Clinical & Translational Oncology

Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy

(2018) Xiao-Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Radiotherapy alone and with concurrent chemotherapy for nasopharyngeal carcinoma

(2018) Atsuto Katano et al.   MEDICINE

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

(2018) Tingting Yang et al.   ONCOGENE

Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition

(2018) Chao Shi et al.   ONCOGENE

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

(2018) Fan Yao et al.   Nature Communications

Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma

(2018) Pierre-Antoine Bissey et al.   Oncogenesis

PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis

(2018) Chuanyao Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma

(2018) Richard Mair et al.   CANCER RESEARCH

Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells

(2018) Wei Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer

(2018) Woong Sub Byun et al.   BIOCHEMICAL PHARMACOLOGY

Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer

(2018) Tapesh Bhattacharyya et al.   Journal of Oncology

Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?

(2018) Victor H. Lee et al.   Journal of Oncology Practice

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

(2017) Xinfang Yu et al.   MOLECULAR CARCINOGENESIS

Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist

(2017) D Ruan et al.   ONCOGENE

BST2 confers cisplatin resistance via NF-κB signaling in nasopharyngeal cancer

(2017) Chun-mei Kuang et al.   Cell Death & Disease

Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target

(2017) Ping Xie et al.   Cell Death & Disease

BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma

(2017) Wei Gao et al.   Cancer Medicine

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop modulated by PDCD4 suppresses cell growth, metastasis and sensitizes nasopharyngeal carcinoma to cisplatin

(2016) Y Zhen et al.   ONCOGENE

Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective

(2015) Anne W.M. Lee et al.   JOURNAL OF CLINICAL ONCOLOGY

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

(2015) Jagadish C. Ghosh et al.   JNCI-Journal of the National Cancer Institute

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

(2015) Szu-Wei Lee et al.   MOLECULAR CELL

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

(2015) Jagadish C. Ghosh et al.   JNCI-Journal of the National Cancer Institute

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

(2014) L Xiao et al.   ONCOGENE

Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors

(2013) Hongling Zhao et al.   CANCER CELL

TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer

(2013) W. Li et al.   CANCER RESEARCH

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

(2013) Chia-Hsin Chan et al.   CELL

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential

(2013) Yu-Feng Tian et al.   TUMOR BIOLOGY

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

(2012) Juan Wu et al.   MOLECULAR CELL

Skp2 is a Promising Therapeutic Target in Breast Cancer

(2012) Zhiwei Wang et al.   Frontiers in Oncology

Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells

(2011) Ching-Chieh Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE