Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors
出版年份 2020 全文链接
标题
Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors
作者
关键词
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出版物
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 31, Issue 5, Pages 907-919
出版商
American Society of Nephrology (ASN)
发表日期
2020-04-11
DOI
10.1681/asn.2020010010
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Biological Functions of Autophagy Genes: A Disease Perspective
- (2019) Beth Levine et al. CELL
- Organelle crosstalk in the kidney
- (2019) Tsuyoshi Inoue et al. KIDNEY INTERNATIONAL
- Role of sirtuin-1 in diabetic nephropathy
- (2019) Wanning Wang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017
- (2019) Kazuhiro Hasegawa Clinical and Experimental Nephrology
- Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model
- (2019) Yin Ying et al. Aging-US
- Hyperglycemia induces NFκ‐B activation and MCP‐1 expression via downregulating GLP‐1R expression in rat mesangial cells: inhibition by metformin
- (2019) Zhanfang Kang et al. CELL BIOLOGY INTERNATIONAL
- Absence of the β1 subunit of AMP ‐activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes
- (2019) Suet‐Wan Choy et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes
- (2019) Shinsuke Sakai et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- (2019) Vlado Perkovic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice Using In Vivo Imaging
- (2019) Kengo Kidokoro et al. CIRCULATION
- Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice
- (2019) Masa-Ki Inoue et al. Diabetology & Metabolic Syndrome
- Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats
- (2019) Sua Kim et al. HYPERTENSION RESEARCH
- Molecular Interactions Between Reactive Oxygen Species and Autophagy in Kidney Disease
- (2019) Gur P. Kaushal et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Liraglutide promotes autophagy by regulating the AMPK/mTOR pathway in a rat remnant kidney model of chronic renal failure
- (2019) Lingyu Xue et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- Insulin promotes sodium transport but suppresses gluconeogenesis via distinct cellular pathways in human and rat renal proximal tubules
- (2019) Motonobu Nakamura et al. KIDNEY INTERNATIONAL
- SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis
- (2019) Brendon L Neuen et al. Lancet Diabetes & Endocrinology
- Effect of Empagliflozin on Erythropoietin Levels, Iron Stores and Red Blood Cell Morphology in Patients with Type 2 Diabetes and Coronary Artery Disease
- (2019) C. David Mazer et al. CIRCULATION
- Pioglitazone protects tubular cells against hypoxia/reoxygenation injury through enhancing autophagy via AMPK-mTOR signaling pathway
- (2019) Xiaoqing Xi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial
- (2019) Erik J.M. van Bommel et al. KIDNEY INTERNATIONAL
- Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy
- (2019) Ryoichi Bessho et al. Scientific Reports
- Mediators of the Effects of Canagliflozin on Heart Failure in Patients With Type 2 Diabetes
- (2019) JingWei Li et al. JACC-Heart Failure
- Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats
- (2019) Alana Aragón-Herrera et al. BIOCHEMICAL PHARMACOLOGY
- Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis
- (2019) Jiang Xu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats
- (2019) Myat Theingi Swe et al. CLINICAL SCIENCE
- Are the cardiovascular and kidney benefits of empagliflozin influenced by baseline glucose‐lowering therapy?
- (2019) Silvio E. Inzucchi et al. DIABETES OBESITY & METABOLISM
- Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules
- (2019) Kohshiro Hosokawa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions
- (2019) Chigure Suzuki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway
- (2019) Huiwen Ren et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells
- (2018) Chenke Xu et al. BIOCHEMICAL PHARMACOLOGY
- Have dipeptidyl peptidase-4 inhibitors ameliorated the vascular complications of type 2 diabetes in large-scale trials? The potential confounding effect of stem-cell chemokines
- (2018) Milton Packer Cardiovascular Diabetology
- Serum level of the autophagy biomarker Beclin-1 in patients with diabetic kidney disease
- (2018) Mervat Naguib et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB
- (2018) Xingchen Zhao et al. JOURNAL OF PATHOLOGY
- Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease
- (2018) Yue Wang et al. Journal of Translational Medicine
- Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury
- (2018) Quan Hong et al. KIDNEY INTERNATIONAL
- Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway
- (2018) Xu Chen et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy
- (2018) Qian Lu et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Autophagy as a promoter of longevity: insights from model organisms
- (2018) Malene Hansen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Intracellular organelles in health and kidney disease
- (2018) Fateme Shamekhi Amiri Nephrologie & Therapeutique
- Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy
- (2018) Sonia Sifuentes-Franco et al. International Journal of Endocrinology
- Ischemic preconditioning attenuates ischemia/reperfusion-induced kidney injury by activating autophagy via the SGK1 signaling pathway
- (2018) Ying Xie et al. Cell Death & Disease
- High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection
- (2018) Hiroyuki Umino et al. Scientific Reports
- Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms
- (2018) Sarah J. Mancini et al. Scientific Reports
- Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways
- (2018) Wenjing Jiang et al. Scientific Reports
- Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
- (2018) Hao Zhou et al. Redox Biology
- Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress
- (2018) Tao Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning
- (2018) Na Lu et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
- (2018) Wei Wei et al. Scientific Reports
- AMPK contributes to autophagosome maturation and lysosomal fusion
- (2018) Minsu Jang et al. Scientific Reports
- Energy restriction in renal protection
- (2018) Si-Yang Wang et al. BRITISH JOURNAL OF NUTRITION
- Metformin inhibits mTOR-HIF-1α axis and profibrogenic and inflammatory biomarkers in thioacetamide-induced hepatic tissue alterations
- (2018) Fahaid Al-Hashem et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences
- (2018) Eric Fontaine Frontiers in Endocrinology
- Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation
- (2018) Elisabet Cuyàs et al. Frontiers in Endocrinology
- Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort
- (2017) Kang Tang et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients
- (2017) Hemat El-Sayed El-Horany et al. IUBMB LIFE
- Evaluation of urinary autophagy transcripts expression in diabetic kidney disease
- (2017) Marwa Matboli et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Selective Activation of AMPK β 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy
- (2017) Christopher T. Salatto et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Advanced glycation end products (AGEs) increase renal lipid accumulation: a pathogenic factor of diabetic nephropathy (DN)
- (2017) Yang Yuan et al. Lipids in Health and Disease
- Hypoxia inducible factor-1α regulates autophagy via the p27-E2F1 signaling pathway
- (2017) Pan Wang et al. Molecular Medicine Reports
- Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
- (2017) Cassiano Felippe Gonçalves-de-Albuquerque et al. MOLECULES
- Mitochondrial energetics in the kidney
- (2017) Pallavi Bhargava et al. Nature Reviews Nephrology
- Liraglutide and Renal Outcomes in Type 2 Diabetes
- (2017) Johannes F.E. Mann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes
- (2017) Siwei Zhang et al. Experimental and Therapeutic Medicine
- Histopathological findings of renal tissue induced by oxidative stress due to different concentrations of fluoride
- (2017) Qin Luo et al. Oncotarget
- SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
- (2017) Yanyan Zhao et al. Scientific Reports
- Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells
- (2017) Junping Hu et al. Scientific Reports
- SDF‐1α (Stromal Cell‐Derived Factor 1α) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen
- (2017) Edwin K. Jackson et al. Journal of the American Heart Association
- The Autophagy Machinery: A New Player in Chemotactic Cell Migration
- (2017) Pierre-Michaël Coly et al. Frontiers in Neuroscience
- Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats
- (2017) Tengis S. Pavlov et al. Frontiers in Physiology
- Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis
- (2017) Kyoung Hye Kong et al. Scientific Reports
- Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes
- (2017) Shingo Muratsubaki et al. Scientific Reports
- The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue
- (2016) Xiaole Li et al. BRITISH JOURNAL OF PHARMACOLOGY
- The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis
- (2016) Hai-Tao Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus
- (2016) Hiddo J.L. Heerspink et al. CIRCULATION
- HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice
- (2016) Bijaya K. Nayak et al. DIABETES
- The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
- (2016) Simon A. Hawley et al. DIABETES
- Effect of Sitagliptin on Kidney Function and Respective Cardiovascular Outcomes in Type 2 Diabetes: Outcomes From TECOS
- (2016) Jan H. Cornel et al. DIABETES CARE
- Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial
- (2016) Ofri Mosenzon et al. DIABETES CARE
- Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3
- (2016) Bethany Baumann et al. KIDNEY INTERNATIONAL
- Prevention of apoptosis averts glomerular tubular disconnection and podocyte loss in proteinuric kidney disease
- (2016) Ievgeniia Burlaka et al. KIDNEY INTERNATIONAL
- Time-dependent activity of Na+/H+ exchanger isoform 1 and homeostasis of intracellular pH in astrocytes exposed to CoCl2 treatment
- (2016) PENG WANG et al. Molecular Medicine Reports
- The NLRP3 inflammasome in kidney disease and autoimmunity
- (2016) Holly L Hutton et al. NEPHROLOGY
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
- (2016) Liqun Ma et al. PATHOLOGY RESEARCH AND PRACTICE
- β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy
- (2016) J Liu et al. Cell Death & Disease
- Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma
- (2016) Talita Antunes Guimarães et al. Oncotarget
- Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis
- (2016) Zhanjun Jia et al. Oncotarget
- Selective Insulin Resistance in the Kidney
- (2016) Shoko Horita et al. Biomed Research International
- SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
- (2016) Matthew D. Hirschey et al. Aging-US
- Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction
- (2016) Jianzhong Li et al. Scientific Reports
- Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
- (2015) Olivia Lenoir et al. Autophagy
- MTOR, PIK3C3, and autophagy: Signaling the beginning from the end
- (2015) Michael J Munson et al. Autophagy
- Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy
- (2015) Atsuko Tagawa et al. DIABETES
- Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy
- (2015) Wei Jing Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of autophagy inducers in clinical medicine
- (2015) Beth Levine et al. JOURNAL OF CLINICAL INVESTIGATION
- SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual subsarcolemmal and intermyofibrillar mitochondria
- (2015) Hao-Hao Zhang et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Regulation of the epithelial Na+channel by the mTORC2/SGK1 pathway
- (2015) Florian Lang et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study
- (2015) Lancet Diabetes & Endocrinology
- Metformin alleviates high glucose-mediated oxidative stress in rat glomerular mesangial cells by modulation of p38 mitogen-activated protein kinase expression in vitro
- (2015) XIN-MING YAO et al. Molecular Medicine Reports
- AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1
- (2014) Yanh Li et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- KB-R7943, a plasma membrane Na+/Ca2+ exchanger inhibitor, blocks opening of the mitochondrial permeability transition pore
- (2014) Brian M. Wiczer et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
- (2014) Evandro Fei Fang et al. CELL
- Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
- (2014) Katharina M. Walter et al. Cell Metabolism
- Role of Transcription Factor Acetylation in Diabetic Kidney Disease
- (2014) R. Liu et al. DIABETES
- Protective effect of truncated Na+/K+‐ATPase β on ischemia/reperfusion-induced renal injury in rats
- (2014) Huilin Gong et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Establishment of an Inflamed Animal Model of Diabetic Nephropathy
- (2014) Kun Ling Ma et al. International Journal of Biological Sciences
- Autophagy in diabetic nephropathy
- (2014) Yan Ding et al. JOURNAL OF ENDOCRINOLOGY
- Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy
- (2014) L. Nordquist et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Functional Role of Glucose Metabolism, Osmotic Stress, and Sodium-Glucose Cotransporter Isoform-Mediated Transport on Na+/H+ Exchanger Isoform 3 Activity in the Renal Proximal Tubule
- (2014) T. D. Pessoa et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
- (2014) Hyun Mi Kang et al. NATURE MEDICINE
- Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC-1α-eNOS pathway and enhanced autophagy
- (2013) J. Lempiäinen et al. Acta Physiologica
- Cell volume and monovalent ion transporters: their role in cell death machinery triggering and progression
- (2013) Sergei N. Orlov et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- (2013) Anu Kauppinen et al. CELLULAR SIGNALLING
- Regulation of ion channels and transporters by AMP-activated kinase (AMPK)
- (2013) Florian Lang et al. Channels
- Sodium-glucose cotransporter 2-mediated oxidative stress augments advanced glycation end products-induced tubular cell apoptosis
- (2013) Sayaka Maeda et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
- (2013) S. Paula-Gomes et al. HORMONE AND METABOLIC RESEARCH
- Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice
- (2013) DAL KIM et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Digoxin Downregulates NDRG1 and VEGF through the Inhibition of HIF-1α under Hypoxic Conditions in Human Lung Adenocarcinoma A549 Cells
- (2013) Dong Wei et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
- (2013) Laura L. Dugan et al. JOURNAL OF CLINICAL INVESTIGATION
- Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress
- (2013) Vikram Prasad et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions
- (2013) K. Yamahara et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Intensive glucose control improves kidney outcomes in patients with type 2 diabetes
- (2013) Vlado Perkovic et al. KIDNEY INTERNATIONAL
- Advanced Glycated End-Products Affect HIF-Transcriptional Activity in Renal Cells
- (2013) Tzvetanka Bondeva et al. MOLECULAR ENDOCRINOLOGY
- Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
- (2013) Kazuhiro Hasegawa et al. NATURE MEDICINE
- Protective Role of AMP-Activated Protein Kinase-Evoked Autophagy on an In Vitro Model of Ischemia/Reperfusion-Induced Renal Tubular Cell Injury
- (2013) Li-Ting Wang et al. PLoS One
- Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
- (2013) Jason A. Funk et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study
- (2012) DIABETES CARE
- Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin
- (2012) Junghyun Kim et al. Experimental Diabetes Research
- The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling
- (2012) Rui Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response
- (2012) Tie Fu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK: a nutrient and energy sensor that maintains energy homeostasis
- (2012) D. Grahame Hardie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration
- (2012) Xiaofang Yu et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
- (2011) T. Weichhart et al. BLOOD
- Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression
- (2011) Abdulqader A. Alhaider et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes
- (2011) Shiro Maeda et al. Clinical and Experimental Nephrology
- Renal Function in Type 2 Diabetes with Rosiglitazone, Metformin, and Glyburide Monotherapy
- (2011) J. M. Lachin et al. Clinical Journal of the American Society of Nephrology
- Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin
- (2011) Yumi Takiyama et al. DIABETES
- Observation on Renal Outcomes in the Veterans Affairs Diabetes Trial
- (2011) L. Agrawal et al. DIABETES CARE
- Autophagy as a Therapeutic Target in Diabetic Nephropathy
- (2011) Yuki Tanaka et al. Experimental Diabetes Research
- Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner
- (2011) Rui Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
- (2011) Ken Inoki et al. JOURNAL OF CLINICAL INVESTIGATION
- Blood oxygen level-dependent (BOLD) MRI of diabetic nephropathy: Preliminary experience
- (2011) Zhen J. Wang et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
- Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients
- (2011) Faramarz Ismail-Beigi et al. KIDNEY INTERNATIONAL
- Oxidative Stress and Diabetic Complications
- (2010) Ferdinando Giacco et al. CIRCULATION RESEARCH
- Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase α1-subunit in rats
- (2010) Lina Nordquist et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
- (2010) Kazuhiro Hasegawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner
- (2010) Ji-Min Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
- (2010) Shinji Kume et al. JOURNAL OF CLINICAL INVESTIGATION
- High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein
- (2010) Tsubasa Isoe et al. KIDNEY INTERNATIONAL
- In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake
- (2010) Dan Yang Huang et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Sirtuin-1 regulation of mammalian metabolism
- (2010) Matthew P. Gillum et al. TRENDS IN MOLECULAR MEDICINE
- The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential
- (2009) Hiroyuki Mori et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of Intracellular and Mitochondrial Sodium in Health and Disease
- (2009) Elizabeth Murphy et al. CIRCULATION RESEARCH
- Sirtuin 1 Functionally and Physically Interacts with Disruptor of Telomeric Silencing-1 to Regulate α-ENaCTranscription in Collecting Duct
- (2009) Dongyu Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aberrant ENaC activation in Dahl salt-sensitive rats
- (2009) Yutaka Kakizoe et al. JOURNAL OF HYPERTENSION
- Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy
- (2009) Chung-Hsin Yeh et al. LIFE SCIENCES
- Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney
- (2009) Y. R. Song et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Reduces Glucose Uptake via the Inhibition of Na+/H+Exchanger 1 in Isolated Rat Ventricular Cardiomyocytes
- (2008) Coralie Ségalen et al. ENDOCRINOLOGY
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
- (2008) Yi Liu et al. NATURE
- Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes
- (2008) Peter Gæde et al. NEW ENGLAND JOURNAL OF MEDICINE
- 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
- (2008) Rury R. Holman et al. NEW ENGLAND JOURNAL OF MEDICINE
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