Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways

Dual inhibition of Akt and c-Met as a second-line therapy following acquired resistance to sorafenib in hepatocellular carcinoma cells

(2017) Peng Han et al.   Molecular Oncology

Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

(2017) Cassiano Felippe Gonçalves-de-Albuquerque et al.   MOLECULES

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

(2017) Tianchi Yu et al.   YONSEI MEDICAL JOURNAL

Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process

(2017) Szymon Kowalski et al.   Oncotarget

The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease

(2017) Michael V. Clausen et al.   Frontiers in Physiology

Personalized therapy for hepatocellular carcinoma: Where are we now?

(2016) Stephen L. Chan et al.   CANCER TREATMENT REVIEWS

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

Targeting Na+/K+-translocating adenosine triphosphatase in cancer treatment

(2015) Cameron T. Durlacher et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Novel drugs in clinical development for hepatocellular carcinoma

(2015) Oliver Waidmann et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na+/K+-ATPase

(2015) Maen Zeino et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells

(2014) Dongdong Chen et al.   BMC CANCER

2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2

(2014) Li Ma et al.   CANCER LETTERS

Sodium orthovanadate inhibits growth of human hepatocellular carcinoma cells in vitro and in an orthotopic model in vivo

(2014) Yaohua Wu et al.   CANCER LETTERS

Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells

(2014) Dali Zhao et al.   CELLULAR SIGNALLING

Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma

(2014) Hala Girgis et al.   Molecular Cancer

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

(2014) B. Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Hepatocellular carcinoma and sorafenib: too many resistance mechanisms?

(2013) Carmen Berasain   GUT

V-ATPase inhibition overcomes trastuzumab resistance in breast cancer

(2013) Karin von Schwarzenberg et al.   Molecular Oncology

Cardiotonic Steroids-Mediated Na+/K+-ATPase Targeting Could Circumvent Various Chemoresistance Pathways

(2013) Tatjana Mijatovic et al.   PLANTA MEDICA

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Human erythrocytes and neuroblastoma cells are in vitro affected by sodium orthovanadate

(2012) M. Suwalsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Resistance and Escape From Antiangiogenesis Therapy: Clinical Implications and Future Strategies

(2012) Justin N. Bottsford-Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells

(2011) Zahid M. Delwar et al.   INVESTIGATIONAL NEW DRUGS

Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1  and 2 

(2011) Q. Lin et al.   MOLECULAR CANCER RESEARCH

Cell metabolism: An essential link between cell growth and apoptosis

(2010) Emily F. Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

(2010) Heidi Menrad et al.   HEPATOLOGY

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

(2009) C. D. Simpson et al.   CANCER RESEARCH

Decavanadate (V10O286-) and oxovanadates: Oxometalates with many biological activities

(2008) Manuel Aureliano et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA