Retention of Gadolinium in Brain Parenchyma: Pathways for Speciation, Access, and Distribution. A Critical Review

Long-Term Evaluation of Gadolinium Retention in Rat Brain After Single Injection of a Clinically Relevant Dose of Gadolinium-Based Contrast Agents

(2020) Izabela Strzeminska et al.   INVESTIGATIVE RADIOLOGY

Quantitative analysis of gd in the protein content of the brain following single injection of gadolinium-based contrast agents (GBCAs) by size exclusion chromatography

(2019) Achmad Adhipatria Perayabangsa Kartamihardja et al.   BRITISH JOURNAL OF RADIOLOGY

Cumulative administrations of gadolinium-based contrast agents: risks of accumulation and toxicity of linear vs macrocyclic agents

(2019) Lara Chehabeddine et al.   CRITICAL REVIEWS IN TOXICOLOGY

Physicochemical and Pharmacokinetic Profiles of Gadopiclenol

(2019) Caroline Robic et al.   INVESTIGATIVE RADIOLOGY

Gadolinium Deposition in the Brain in a Large Animal Model

(2019) Alexander Radbruch et al.   INVESTIGATIVE RADIOLOGY

Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide

(2019) Carlo A. Mallio et al.   INVESTIGATIVE RADIOLOGY

Glymphatic imaging using MRI

(2019) Toshiaki Taoka et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Gadolinium-based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study

(2018) Stefanie Fingerhut et al.   ACTA NEUROPATHOLOGICA

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

(2018) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Gadolinium Accumulation in the Deep Cerebellar Nuclei and Globus Pallidus After Exposure to Linear but Not Macrocyclic Gadolinium-Based Contrast Agents in a Retrospective Pig Study With High Similarity to Clinical Conditions

(2018) Janina Boyken et al.   INVESTIGATIVE RADIOLOGY

Gadolinium Retention, Brain T1 Hyperintensity, and Endogenous Metals

(2018) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain

(2018) Toshiaki Taoka et al.   INVESTIGATIVE RADIOLOGY

Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum

(2018) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Spatially resolved quantification of gadolinium deposited in the brain of a patient treated with gadolinium-based contrast agents

(2018) Stefanie Fingerhut et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Association of exposure to manganese and iron with relaxation rates R1 and R2*- magnetic resonance imaging results from the WELDOX II study

(2018) Beate Pesch et al.   NEUROTOXICOLOGY

Gadolinium Distribution in Cerebrospinal Fluid after Administration of a Gadolinium-based MR Contrast Agent in Humans

(2018) Florian Berger et al.   RADIOLOGY

Accumulation of Gadolinium in Human Cerebrospinal Fluid after Gadobutrol-enhanced MR Imaging: A Prospective Observational Cohort Study

(2018) Avinash K. Nehra et al.   RADIOLOGY

One-year Retention of Gadolinium in the Brain: Comparison of Gadodiamide and Gadoterate Meglumine in a Rodent Model

(2018) Philippe Robert et al.   RADIOLOGY

Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain

(2018) Katerina Deike-Hofmann et al.   INVESTIGATIVE RADIOLOGY

LA-ICP-MS/MS improves limits of detection in elemental bioimaging of gadolinium deposition originating from MRI contrast agents in skin and brain tissues

(2018) David Clases et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Long-term Excretion of Gadolinium-based Contrast Agents: Linear versus Macrocyclic Agents in an Experimental Rat Model

(2018) Gregor Jost et al.   RADIOLOGY

Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?

(2018) Nathalie Fretellier et al.   INVESTIGATIVE RADIOLOGY

Impact of Treatment With Chelating Agents Depends on the Stability of Administered GBCAs

(2018) Janina Boyken et al.   INVESTIGATIVE RADIOLOGY

Histology and Gadolinium Distribution in the Rodent Brain After the Administration of Cumulative High Doses of Linear and Macrocyclic Gadolinium-Based Contrast Agents

(2017) Jessica Lohrke et al.   INVESTIGATIVE RADIOLOGY

Quantification and Assessment of the Chemical Form of Residual Gadolinium in the Brain After Repeated Administration of Gadolinium-Based Contrast Agents

(2017) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Moderate Renal Failure Accentuates T1 Signal Enhancement in the Deep Cerebellar Nuclei of Gadodiamide-Treated Rats

(2017) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

(2017) Mony J. de Leon et al.   JOURNAL OF NUCLEAR MEDICINE

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T

(2017) Hedok Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Distribution map of gadolinium deposition within the cerebellum following GBCA administration

(2017) Donna R. Roberts et al.   NEUROLOGY

Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents

(2017) Eliana Gianolio et al.   RADIOLOGY

Comparison of Gadolinium Concentrations within Multiple Rat Organs after Intravenous Administration of Linear versus Macrocyclic Gadolinium Chelates

(2017) Robert J. McDonald et al.   RADIOLOGY

Gadolinium Deposition in Human Brain Tissues after Contrast-enhanced MR Imaging in Adult Patients without Intracranial Abnormalities

(2017) Robert J. McDonald et al.   RADIOLOGY

Extent of Signal Hyperintensity on Unenhanced T1-weighted Brain MR Images after More than 35 Administrations of Linear Gadolinium-based Contrast Agents

(2017) Yang Zhang et al.   RADIOLOGY

Poor human olfaction is a 19th-century myth

(2017) John P. McGann   SCIENCE

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives

(2016) Jessica Lohrke et al.   ADVANCES IN THERAPY

Progressive increase of T1 signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images in the pediatric brain exposed to multiple doses of gadolinium contrast

(2016) Donna R. Roberts et al.   BRAIN & DEVELOPMENT

Distribution and clearance of retained gadolinium in the brain: differences between linear and macrocyclic gadolinium based contrast agents in a mouse model

(2016) A Adhipatria P Kartamihardja et al.   BRITISH JOURNAL OF RADIOLOGY

Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue

(2016) Gregor Jost et al.   EUROPEAN RADIOLOGY

Impact of Impaired Renal Function on Gadolinium Retention After Administration of Gadolinium-Based Contrast Agents in a Mouse Model

(2016) A. Adhipatria P. Kartamihardja et al.   INVESTIGATIVE RADIOLOGY

Effect of Renal Function on Gadolinium-Related Signal Increases on Unenhanced T1-Weighted Brain Magnetic Resonance Imaging

(2016) Yan Cao et al.   INVESTIGATIVE RADIOLOGY

Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats

(2016) Philippe Robert et al.   INVESTIGATIVE RADIOLOGY

The Translational Significance of the Neurovascular Unit

(2016) Heather L. McConnell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are some agents less likely to deposit gadolinium in the brain?

(2016) Alexander Radbruch   MAGNETIC RESONANCE IMAGING

The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity

(2015) Toshitaka Oohashi et al.   EXPERIMENTAL NEUROLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy

(2015) Tomonori Kanda et al.   RADIOLOGY

Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging

(2015) Robert J. McDonald et al.   RADIOLOGY

Development of the choroid plexus and blood-CSF barrier

(2015) Shane A. Liddelow   Frontiers in Neuroscience

Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

(2014) Ruibin Li et al.   ACS Nano

Progressive Increase of T1 Signal Intensity of the Dentate Nucleus on Unenhanced Magnetic Resonance Images Is Associated With Cumulative Doses of Intravenously Administered Gadodiamide in Patients With Normal Renal Function, Suggesting Dechelation

(2014) Yuri Errante et al.   INVESTIGATIVE RADIOLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol

(2014) Shinji NAGANAWA et al.   Magnetic Resonance in Medical Sciences

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-weighted MR Images: Relationship with Increasing Cumulative Dose of a Gadolinium-based Contrast Material

(2013) Tomonori Kanda et al.   RADIOLOGY

Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus

(2012) Ruth Roales-Buján et al.   ACTA NEUROPATHOLOGICA

Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus

(2012) Arnulf H. Koeppen et al.   CEREBELLUM

Gadolinium-containing magnetic resonance contrast media: investigation on the possible transchelation of Gd3+to the glycosaminoglycan heparin

(2012) Matthias Taupitz et al.   Contrast Media & Molecular Imaging

Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines

(2012) Henrik S. Thomsen et al.   EUROPEAN RADIOLOGY

Use of Contrast Media in Neuroimaging

(2012) Marco Essig et al.   Magnetic Resonance Imaging Clinics of North America

Ocular Pathologic Features and Gadolinium Deposition in Nephrogenic Systemic Fibrosis

(2011) Ann Barker-Griffith   ARCHIVES OF OPHTHALMOLOGY

Human brain iron mapping using atlas-based T2 relaxometry

(2011) Khader M. Hasan et al.   MAGNETIC RESONANCE IN MEDICINE

Mapping Brain Metals to Evaluate Therapies for Neurodegenerative Disease

(2010) Bogdan Florin Gh Popescu et al.   CNS Neuroscience & Therapeutics

Iron, Copper, and Zinc Distribution of the Cerebellum

(2009) Bogdan F. Gh. Popescu et al.   CEREBELLUM

Involvement of Gadolinium Chelates in the Mechanism of Nephrogenic Systemic Fibrosis: An Update

(2009) Jean-Marc Idée et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review

(2008) Marc Port et al.   BIOMETALS

Lysosomes in iron metabolism, ageing and apoptosis

(2008) Tino Kurz et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

(2008) David Sulzer et al.   JOURNAL OF NEUROCHEMISTRY

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY