Cumulative administrations of gadolinium-based contrast agents: risks of accumulation and toxicity of linear vs macrocyclic agents

Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis

(2019) Philipp Eisele et al.   MAGNETIC RESONANCE IMAGING

High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted MR Images: Comparison between Gadobutrol and Linear Gadolinium-Based Contrast Agents

(2018) F.G. Moser et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Development of High Signal Intensity within the Globus Pallidus and Dentate Nucleus following Multiple Administrations of Gadobenate Dimeglumine

(2018) G.M. Bolles et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Gadolinium-Based Contrast Agents in Kidney Disease: Comprehensive Review and Clinical Practice Guideline Issued by the Canadian Association of Radiologists

(2018) Nicola Schieda et al.   CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES

Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration

(2018) J.R. Young et al.   CLINICAL RADIOLOGY

Weekly enhanced T1-weighted MRI with Gadobutrol injections in MS patients: Is there a signal intensity increase in the dentate nucleus and the globus pallidus?

(2018) Paul Jaulent et al.   EUROPEAN JOURNAL OF RADIOLOGY

Gadolinium deposition within the paediatric brain: no increased intrinsic T1-weighted signal intensity within the dentate nucleus following the administration of a minimum of four doses of the macrocyclic agent gadobutrol

(2018) Jonathan R. Young et al.   EUROPEAN RADIOLOGY

Gadolinium Retention, Brain T1 Hyperintensity, and Endogenous Metals

(2018) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Pediatric Brain

(2018) Young Jin Ryu et al.   INVESTIGATIVE RADIOLOGY

Evaluation of Gadolinium Retention After Serial Administrations of a Macrocyclic Gadolinium-Based Contrast Agent (Gadobutrol)

(2018) Roh-Eul Yoo et al.   INVESTIGATIVE RADIOLOGY

Signal Changes in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Magnetic Resonance Images After Intrathecal Administration of Macrocyclic Gadolinium Contrast Agent

(2018) Kerem Ozturk et al.   INVESTIGATIVE RADIOLOGY

Methodological Aspects for Preclinical Evaluation of Gadolinium Presence in Brain Tissue

(2018) Philippe Robert et al.   INVESTIGATIVE RADIOLOGY

Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain

(2018) Toshiaki Taoka et al.   INVESTIGATIVE RADIOLOGY

Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum

(2018) Marlène Rasschaert et al.   INVESTIGATIVE RADIOLOGY

Spatiotemporal Pattern of Gadodiamide-Related T1 Hyperintensity Increase Within the Deep Brain Nuclei

(2018) Guillaume P.O. Marie et al.   INVESTIGATIVE RADIOLOGY

Spatially resolved quantification of gadolinium deposited in the brain of a patient treated with gadolinium-based contrast agents

(2018) Stefanie Fingerhut et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Changes in signal intensity in the dentate nucleus at unenhanced T1-weighted magnetic resonance imaging depending on class of previously used gadolinium-based contrast agent

(2018) Eileen Kasper et al.   PEDIATRIC RADIOLOGY

Dentate Nucleus Signal Intensity Decrease on T1-weighted MR Images after Switching from Gadopentetate Dimeglumine to Gadobutrol

(2018) Ashkan Heshmatzadeh Behzadi et al.   RADIOLOGY

Changes in Signal Intensity of the Dentate Nucleus and Globus Pallidus in Pediatric Patients: Impact of Brain Irradiation and Presence of Primary Brain Tumors Independent of Linear Gadolinium-based Contrast Agent Administration

(2018) Benita Tamrazi et al.   RADIOLOGY

Brain Irradiation and Gadobutrol Administration in Pediatric Patients with Brain Tumors: Effect on MRI Brain Signal Intensity

(2018) Benita Tamrazi et al.   RADIOLOGY

T1 Shortening in the Globus Pallidus after Multiple Administrations of Gadobutrol: Assessment with a Multidynamic Multiecho Sequence

(2018) Koung Mi Kang et al.   RADIOLOGY

Observed Deposition of Gadolinium in Bone Using a New Noninvasive in Vivo Biomedical Device: Results of a Small Pilot Feasibility Study

(2018) Michelle L. Lord et al.   RADIOLOGY

Choosing the Safest Gadolinium-based Contrast Medium for MR Imaging: Not So Simple after All

(2018) Matthew S. Davenport   RADIOLOGY

Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents

(2018) H. Kang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Progressive T1 Shortening of the Dentate Nucleus in Patients With Multiple Sclerosis: Result of Multiple Administrations of Linear Gadolinium Contrast Agents Versus Intrinsic Disease

(2018) Ajay Malhotra et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Evaluation of Gadolinium Deposition in the Brain After MR Arthrography

(2018) Stephen F. Kralik et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Evaluation of the effect of switching from a linear to a macrocyclic contrast agent on the T1 -weighted brain signal intensity of a child during the course of 43 contrast-enhanced MRI examinations

(2018) Ryan K. Robison et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Long-term Excretion of Gadolinium-based Contrast Agents: Linear versus Macrocyclic Agents in an Experimental Rat Model

(2018) Gregor Jost et al.   RADIOLOGY

Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?

(2018) Nathalie Fretellier et al.   INVESTIGATIVE RADIOLOGY

Impact of Treatment With Chelating Agents Depends on the Stability of Administered GBCAs

(2018) Janina Boyken et al.   INVESTIGATIVE RADIOLOGY

Gadolinium retention after administration of contrast agents based on linear chelators and the recommendations of the European Medicines Agency

(2017) Ilona A. Dekkers et al.   EUROPEAN RADIOLOGY

Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images—a voxel-based whole brain analysis

(2017) Soenke Langner et al.   EUROPEAN RADIOLOGY

Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study

(2017) Giorgio Conte et al.   EUROPEAN RADIOLOGY

Gadolinium deposition in the brain: association with various GBCAs using a generalized additive model

(2017) Sohi Bae et al.   EUROPEAN RADIOLOGY

Comparison of Unenhanced T1-Weighted Signal Intensities Within the Dentate Nucleus and the Globus Pallidus After Serial Applications of Gadopentetate Dimeglumine Versus Gadobutrol in a Pediatric Population

(2017) Diane M. Renz et al.   INVESTIGATIVE RADIOLOGY

Intrathecal Contrast-Enhanced Magnetic Resonance Imaging–Related Brain Signal Changes

(2017) Ali Yusuf Öner et al.   INVESTIGATIVE RADIOLOGY

Contrast Agent–Induced High Signal Intensity in Dentate Nucleus on Unenhanced T1-Weighted Images

(2017) Shintaro Ichikawa et al.   INVESTIGATIVE RADIOLOGY

Quantification and Assessment of the Chemical Form of Residual Gadolinium in the Brain After Repeated Administration of Gadolinium-Based Contrast Agents

(2017) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-Based Contrast Agents

(2017) Miguel Ramalho et al.   Magnetic Resonance Imaging Clinics of North America

Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children

(2017) Maria Camilla Rossi Espagnet et al.   PEDIATRIC RADIOLOGY

Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review

(2017) Ingrid Böhm et al.   POSTGRADUATE MEDICINE

Effects of serial macrocyclic-based contrast materials gadoterate meglumine and gadobutrol administrations on gadolinium-related dentate nuclei signal increases in unenhanced T1-weighted brain: a retrospective study in 158 multiple sclerosis (MS) patients

(2017) Alessandra Splendiani et al.   Radiologia Medica

Gadolinium Brain Deposition after Macrocyclic Gadolinium Administration: A Pediatric Case-Control Study

(2017) Daniel Tibussek et al.   RADIOLOGY

Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents

(2017) Eliana Gianolio et al.   RADIOLOGY

Pediatric Brain: Repeated Exposure to Linear Gadolinium-based Contrast Material Is Associated with Increased Signal Intensity at Unenhanced T1-weighted MR Imaging

(2017) Thomas F. Flood et al.   RADIOLOGY

Signal Enhancement of the Dentate Nucleus at Unenhanced MR Imaging after Very High Cumulative Doses of the Macrocyclic Gadolinium-based Contrast Agent Gadobutrol: An Observational Study

(2017) Atle Bjørnerud et al.   RADIOLOGY

Gadolinium Retention in the Body and Brain: Is It Time for an International Joint Research Effort?

(2017) Carlo Cosimo Quattrocchi et al.   RADIOLOGY

Is There Long-term Signal Intensity Increase in the Central Nervous System on T1-weighted Images after MR Imaging with the Hepatospecific Contrast Agent Gadoxetic Acid? A Cross-sectional Study in 91 Patients

(2017) Johannes Kahn et al.   RADIOLOGY

No Signal Intensity Increase in the Dentate Nucleus on Unenhanced T1-weighted MR Images after More than 20 Serial Injections of Macrocyclic Gadolinium-based Contrast Agents

(2017) Alexander Radbruch et al.   RADIOLOGY

Extent of Signal Hyperintensity on Unenhanced T1-weighted Brain MR Images after More than 35 Administrations of Linear Gadolinium-based Contrast Agents

(2017) Yang Zhang et al.   RADIOLOGY

Brain relaxometry after macrocyclic Gd-based contrast agent

(2017) Andreas Müller et al.   Clinical Neuroradiology

25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives

(2016) Jessica Lohrke et al.   ADVANCES IN THERAPY

Pediatric Patients Demonstrate Progressive T1-Weighted Hyperintensity in the Dentate Nucleus following Multiple Doses of Gadolinium-Based Contrast Agent

(2016) D.R. Roberts et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences

(2016) J. Ramalho et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Signal Change in the Dentate Nucleus on T1-Weighted MR Images After Multiple Administrations of Gadopentetate Dimeglumine Versus Gadobutrol

(2016) Yan Cao et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Progressive increase of T1 signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images in the pediatric brain exposed to multiple doses of gadolinium contrast

(2016) Donna R. Roberts et al.   BRAIN & DEVELOPMENT

Increased Signal Intensity in the Dentate Nucleus of Patients with Multiple Sclerosis in Comparison with Neuromyelitis Optica Spectrum Disorder after Multiple Doses of Gadolinium Contrast

(2016) Masami Tanaka et al.   EUROPEAN NEUROLOGY

Intravenous injection of gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years

(2016) Marie-Luise Kromrey et al.   EUROPEAN RADIOLOGY

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

(2016) Enrico Tedeschi et al.   EUROPEAN RADIOLOGY

Signal intensity change on unenhanced T1-weighted images in dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide

(2016) Joana Ramalho et al.   EUROPEAN RADIOLOGY

Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue

(2016) Gregor Jost et al.   EUROPEAN RADIOLOGY

Signal Increase on Unenhanced T1-Weighted Images in the Rat Brain After Repeated, Extended Doses of Gadolinium-Based Contrast Agents

(2016) Gregor Jost et al.   INVESTIGATIVE RADIOLOGY

Effect of Renal Function on Gadolinium-Related Signal Increases on Unenhanced T1-Weighted Brain Magnetic Resonance Imaging

(2016) Yan Cao et al.   INVESTIGATIVE RADIOLOGY

Intraindividual Analysis of Signal Intensity Changes in the Dentate Nucleus After Consecutive Serial Applications of Linear and Macrocyclic Gadolinium-Based Contrast Agents

(2016) Alexander Radbruch et al.   INVESTIGATIVE RADIOLOGY

Macrocyclic and Other Non–Group 1 Gadolinium Contrast Agents Deposit Low Levels of Gadolinium in Brain and Bone Tissue

(2016) Nozomu Murata et al.   INVESTIGATIVE RADIOLOGY

Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats

(2016) Philippe Robert et al.   INVESTIGATIVE RADIOLOGY

Association Between Gadolinium Contrast Exposure and the Risk of Parkinsonism

(2016) Blayne Welk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Quantitative assessment of gadolinium deposition in dentate nucleus using quantitative susceptibility mapping

(2016) Takuya Hinoda et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Self-reported gadolinium toxicity: A survey of patients with chronic symptoms

(2016) Lauren M.B. Burke et al.   MAGNETIC RESONANCE IMAGING

Gadolinium deposition disease: Initial description of a disease that has been around for a while

(2016) Richard C. Semelka et al.   MAGNETIC RESONANCE IMAGING

Lack of increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis

(2016) Philipp Eisele et al.   MEDICINE

Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients

(2016) Ludwig Schlemm et al.   Multiple Sclerosis Journal

Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams

(2016) Houchun H. Hu et al.   PEDIATRIC RADIOLOGY

Hepatic Gadolinium Deposition and Reversibility after Contrast Agent–enhanced MR Imaging of Pediatric Hematopoietic Stem Cell Transplant Recipients

(2016) Natalia Maximova et al.   RADIOLOGY

Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients

(2016) Ludwig Schlemm et al.   Multiple Sclerosis Journal

Gadolinium-Based Contrast Agent Accumulation and Toxicity: An Update

(2015) J. Ramalho et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The Role of Equilibrium and Kinetic Properties in the Dissociation of Gd[DTPA-bis(methylamide)] (Omniscan) at near to Physiological Conditions

(2015) Zsolt Baranyai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol

(2015) Dragan A. Stojanov et al.   EUROPEAN RADIOLOGY

Gadodiamide and Dentate Nucleus T1 Hyperintensity in Patients With Meningioma Evaluated by Multiple Follow-Up Contrast-Enhanced Magnetic Resonance Examinations With No Systemic Interval Therapy

(2015) Carlo Cosimo Quattrocchi et al.   INVESTIGATIVE RADIOLOGY

Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration

(2015) Lukas D. Weberling et al.   INVESTIGATIVE RADIOLOGY

T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats

(2015) Philippe Robert et al.   INVESTIGATIVE RADIOLOGY

High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images

(2015) Alexander Radbruch et al.   INVESTIGATIVE RADIOLOGY

MRI Brain Signal Intensity Changes of a Child During the Course of 35 Gadolinium Contrast Examinations

(2015) J. H. Miller et al.   PEDIATRICS

High Signal Intensity in Globus Pallidus and Dentate Nucleus on Unenhanced T1-weighted MR Images: Evaluation of Two Linear Gadolinium-based Contrast Agents

(2015) Joana Ramalho et al.   RADIOLOGY

High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration

(2015) Tomonori Kanda et al.   RADIOLOGY

Gadolinium Retention in the Dentate Nucleus and Globus Pallidus Is Dependent on the Class of Contrast Agent

(2015) Alexander Radbruch et al.   RADIOLOGY

Gadolinium-based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy

(2015) Tomonori Kanda et al.   RADIOLOGY

Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging

(2015) Robert J. McDonald et al.   RADIOLOGY

The role of gadolinium chelates in the mechanism of nephrogenic systemic fibrosis: A critical update

(2014) Jean-Marc Idée et al.   CRITICAL REVIEWS IN TOXICOLOGY

Progressive Increase of T1 Signal Intensity of the Dentate Nucleus on Unenhanced Magnetic Resonance Images Is Associated With Cumulative Doses of Intravenously Administered Gadodiamide in Patients With Normal Renal Function, Suggesting Dechelation

(2014) Yuri Errante et al.   INVESTIGATIVE RADIOLOGY

High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-weighted MR Images: Relationship with Increasing Cumulative Dose of a Gadolinium-based Contrast Material

(2013) Tomonori Kanda et al.   RADIOLOGY

Bone as Target Organ for Metals: The Case of f-Elements

(2012) Claude Vidaud et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Dissociation Kinetics of Open-Chain and Macrocyclic Gadolinium(III)-Aminopolycarboxylate Complexes Related to Magnetic Resonance Imaging: Catalytic Effect of Endogenous Ligands

(2012) Zsolt Baranyai et al.   CHEMISTRY-A EUROPEAN JOURNAL

MRI contrast agents: Basic chemistry and safety

(2012) Dapeng Hao et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Skin Gadolinium Following Use of MR Contrast Agents in a Rat Model of Nephrogenic Systemic Fibrosis

(2012) John Haylor et al.   RADIOLOGY

Gadolinium-bound contrast agents: No evidence-based data to support a relationship between structure and hypersensitivity reactions

(2012) Jean-Marc Idee et al.   INDIAN JOURNAL OF DERMATOLOGY

Hyperphosphataemia sensitizes renally impaired rats to the profibrotic effects of gadodiamide

(2011) N Fretellier et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Developmental History of the Gadolinium Chelates as Intravenous Contrast Media for Magnetic Resonance

(2011) Val M. Runge et al.   INVESTIGATIVE RADIOLOGY

Gadoxetate Disodium–Enhanced MRI of the Liver: Part 1, Protocol Optimization and Lesion Appearance in the Noncirrhotic Liver

(2010) Kristina I. Ringe et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C

(2010) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Clinical, Biological, and Skin Histopathologic Effects of Ionic Macrocyclic and Nonionic Linear Gadolinium Chelates in a Rat Model of Nephrogenic Systemic Fibrosis

(2010) Nathalie Fretellier et al.   INVESTIGATIVE RADIOLOGY

Role of thermodynamic and kinetic parameters in gadolinium chelate stability

(2009) Jean-Marc Idée et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Incorporation of excess gadolinium into human bone from medical contrast agents

(2009) Thomas H. Darrah et al.   Metallomics

Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review

(2008) Marc Port et al.   BIOMETALS

Gadolinium(iii) complexes as MRI contrast agents: ligand design and properties of the complexes

(2008) Petr Hermann et al.   DALTON TRANSACTIONS

Preclinical investigation to compare different gadolinium-based contrast agents regarding their propensity to release gadolinium in vivo and to trigger nephrogenic systemic fibrosis-like lesions

(2008) Martin A. Sieber et al.   EUROPEAN RADIOLOGY

NSF: WHAT WE KNOW AND WHAT WE NEED TO KNOW: Patient Characteristics and Risk Factors for Nephrogenic Systemic Fibrosis Following Gadolinium Exposure

(2008) Thomas Grobner et al.   SEMINARS IN DIALYSIS