Article
Chemistry, Physical
Youzhi Li, Michel Nguyen, Laure Vendier, Anne Robert, Yan Liu, Bernard Meunier
Summary: TDMQ chelators have been designed as drug-candidates for regulating copper homeostasis and reducing oxidative stress in the brain of Alzheimer's patients. By studying the correlation between the structures and physicochemical properties of Cu- and Zn-TDMQ complexes, it helps to select the most promising drug-candidates for further biological studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Analytical
Stephane Roudeau, Benjamin G. Trist, Asuncion Carmona, Katherine M. Davies, Glenda M. Halliday, Yann Rufin, Stephane Claverol, Stijn J. M. Van Malderen, Gerald Falkenberg, Kay L. Double, Richard Ortega
Summary: A new methodology was developed to analyze the metal content of copper-zinc superoxide dismutase (SOD1) in tissues from the human central nervous system, demonstrating successful preservation of metal, activity, and enrichment of the protein. Results showed Cu and Zn bound to SOD1 in a ratio very close to the expected value of 1, in tissues from healthy individuals. This approach can be adapted to study other metalloproteins in human tissues and other sources.
ANALYTICAL CHEMISTRY
(2021)
Article
Plant Sciences
Philomin Juliana, Velu Govindan, Leonardo Crespo-Herrera, Suchismita Mondal, Julio Huerta-Espino, Sandesh Shrestha, Jesse Poland, Ravi P. Singh
Summary: This study identified consistently significant genotyping-by-sequencing markers associated with grain zinc concentration and grain iron concentration through genome-wide association mapping. The markers showed common associations across different environments, indicating the feasibility of indirect selection for these micronutrients. The study also revealed a quantitative genetic control of these traits, suggesting limited prospects for marker-assisted selection and the need for genomic selection.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Environmental
Vijay Kumar Garg, Ankush Tanta, Arun Lal Srivastav, M. K. Tiwari, Ajay Sharma, Varinder Singh Kanwar
Summary: Pollutants released from pharmaceutical, steel, paper, and battery industries into water cause irreparable damage to the biotic system by entering the natural ecosystems and human food chain. Monitoring and determining heavy metal levels in water are crucial for human beings. In this study, TXRF spectrometry technique was used to assess the contaminant levels in water samples from an industrial area. The elemental concentrations were compared to the guidelines from WHO and BIS, and water quality parameters were assessed. The results showed that some water samples were unfit for drinking with high levels of lead and other heavy metals.
WATER ENVIRONMENT RESEARCH
(2022)
Article
Environmental Sciences
Loredana Brinza, Imad Ahmed, Carmen-Madalina Cismasiu, Ioan Ardelean, Iuliana Gabriela Breaban, Florica Doroftei, Konstantin Ignatyev, Cristina Moisescu, Mariana Neamtu
Summary: Auriferous sulphide ores containing micro-fine gold and silver particles pose extraction challenges, with bioleaching as an environmentally friendly alternative. Experimental findings suggest that iron-oxidizing bacteria can facilitate the release of gold and silver. Utilizing synchrotron-based micro-analysis offers insights into the sequestration and speciation of noble metals.
Article
Biotechnology & Applied Microbiology
Samuel L. Zelinka, Joseph E. Jakes, Grant T. Kirker, Amy B. Bishell, Charles R. Boardman, Barry Lai, George E. Sterbinsky, Jody Jellison, Barry Goodell
Summary: X-ray absorption near edge spectroscopy experiments on wood decayed by brown rot fungi showed that the oxidation states of manganese were mainly Mn2+ and iron mainly Fe3+, with significant Fe2+ present in some cases. Areas of reduced iron corresponded with higher fungal hyphal mass, consistent with the brown rot fungi decay mechanism via chelator-mediated Fenton reaction. Limited changes in manganese oxidation state in wood with active fungal activity suggest the role of manganese in CMF biodegradation chemistry warrants further exploration.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2021)
Article
Thermodynamics
Colin Banyon, Matthew J. Montgomery, Hyunguk Kwon, Alan L. Kastengren, Lisa D. Pfefferle, Travis Sikes, Yuan Xuan, Charles S. McEnally, Robert S. Tranter
Summary: This study presents high-fidelity temperature field measurements of heavily-sooting ethylene/air flames using x-ray fluorescence (XRF) measurements. The challenges faced by conventional optical diagnostics have been overcome by implementing the XRF method with a fluorescent agent. The results demonstrate the efficacy and cost-effectiveness of this method in accurately interpreting the experimental signals.
COMBUSTION AND FLAME
(2023)
Article
Imaging Science & Photographic Technology
Wolf Osterode, Gerald Falkenberg, Heinz Regele
Summary: This study investigated the distribution of gadolinium (Gd) in a renal allograft using microscopic synchrotron X-ray fluorescence. Gd was found to be heterogeneously distributed in areas with interstitial fibrosis and tubular atrophy. No significant correlations were observed between Gd and other bio-metals. These findings provide insights into Gd metabolism.
JOURNAL OF IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Beata Tarnacka, Anna Jopowicz, Maria Maslinska
Summary: Copper, manganese, and iron are essential elements for appropriate brain development and function, but their imbalance can lead to various neurological conditions. This review focuses on neurological disorders associated with excess copper, iron, and manganese, and discusses the diagnosis and potential treatment of these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Marco Aurelio Speranca, Juan Esteban Mayorquin-Guevara, Mara Cristina Pessoa da Cruz, Gustavo Henrique de Almeida Teixeira, Fabiola Manhas Verbi Pereira
Summary: Biofortification is crucial for enhancing nutrients in staple foods, with zinc monitoring being essential for bananas; injecting zinc sulfate into banana trees showed the potential for high throughput analysis of zinc content in biofortified bananas.
Article
Biochemistry & Molecular Biology
Alexander P. Morrell, Richard A. Martin, Helen M. Roberts, Hiram Castillo-Michel, J. Frederick W. Mosselmans, Kalotina Geraki, Adrian T. Warfield, Paul Lingor, Wasif Qayyum, Daniel Graf, Maria Febbraio, Owen Addison
Summary: Exposure to exogenous particles is a growing concern for human health. To understand the associated biological response, it is important to characterize the concentrations, chemical species, distribution, and involvement of the stimulus with the tissue microanatomy. However, no single imaging technique can capture all these features at once, which limits correlative analyses. Developing synchronous imaging strategies that can identify multiple features simultaneously is crucial for assessing spatial relationships with greater confidence.
Article
Environmental Sciences
Lorella Pascolo, Maria Pachetti, Anna Camillo, Alice Cernogoraz, Clara Rizzardi, Katarina Vogel Mikus, Fabrizio Zanconati, Murielle Salome, Vanessa Tardillo Suarez, Federico Romano, Gabriella Zito, Alessandra Gianoncelli, Giuseppe Ricci
Summary: This study reveals the abnormal accumulation of iron and co-localization of environmental metals in ovarian endometriomas of endometriosis patients, suggesting a potential role in the pathogenesis of endometriosis. The findings provide insights into the relationship between iron dysmetabolism, accumulation of environmental metals, and the development of endometriosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Polymer Science
Martin Hruby, Irma Ivette Santana Martinez, Holger Stephan, Pavla Pouckova, Jiri Benes, Petr Stepanek
Summary: Iron and copper are essential micronutrients for cell function, but can be toxic in excess. Current therapy for iron and copper overload using low-molecular-weight chelators has limitations, leading to exploration of polymer-supported chelating therapeutics as a promising alternative.
Article
Computer Science, Artificial Intelligence
A. Rakotondrajoa, M. Radtke
Summary: This study utilized artificial neural networks (ANNs) for quantifying x-ray fluorescence measurements, using Monte Carlo simulation to generate training data and demonstrating the ability to generate additional data through ANN. Emphasis was placed on comparing simulated and experimental data comparability and reducing the influence of deviations, while also describing the search for optimal hyperparameters.
MACHINE LEARNING-SCIENCE AND TECHNOLOGY
(2021)
Article
Environmental Sciences
Xingwen Lu, Zebiao Huang, Zhihong Liang, Zhe Li, Jiani Yang, Yujie Wang, Fei Wang
Summary: This study investigated the influence of Cu and Zn on the precipitation of struvite, showing that the addition of Cu and/or Zn can disrupt the crystalline growth of struvite and promote the formation of amorphous phases. When Cu and Zn coexisted, there was competitive binding of PO4 between the two metals. Overall, the presence of Cu and Zn during struvite formation greatly affects its content by forming different metal-containing products.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)