Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

(2020) Xiaoxiao Wan et al.   NATURE IMMUNOLOGY

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset

(2019) Louis Gioia et al.   Science Immunology

Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice

(2018) Javier A. Carrero et al.   DIABETES

Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes

(2018) Jamie L. Felton et al.   JOURNAL OF IMMUNOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

(2018) Ruby Alonso et al.   Nature Communications

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

(2018) Xiaoxiao Wan et al.   NATURE

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

(2017) Elise Dalmas et al.   IMMUNITY

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

(2017) Stephen T. Ferris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Origins, Recruitment, and Regulation of CD11c+Cells in Inflamed Islets of Autoimmune Diabetes Mice

(2017) Joanna E. Klementowicz et al.   JOURNAL OF IMMUNOLOGY

Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection

(2017) Samad A. Ibitokou et al.   JOURNAL OF IMMUNOLOGY

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Imaging the emergence and natural progression of spontaneous autoimmune diabetes

(2017) James F. Mohan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis

(2016) Jean Fan et al.   NATURE METHODS

The pancreas anatomy conditions the origin and properties of resident macrophages

(2015) Boris Calderon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor

(2015) Gary E Grajales-Reyes et al.   NATURE IMMUNOLOGY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes

(2014) Stephen T. Ferris et al.   IMMUNITY

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

(2013) Boris Calderon et al.   CURRENT OPINION IN IMMUNOLOGY

CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity

(2013) Yosuke Kumamoto et al.   IMMUNITY

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

   T Cells Are Essential Effectors of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2013) J. G. M. Markle et al.   JOURNAL OF IMMUNOLOGY

B Lymphocyte "Original Sin" in the Bone Marrow Enhances Islet Autoreactivity in Type 1 Diabetes-Prone Nonobese Diabetic Mice

(2013) R. A. Henry-Bonami et al.   JOURNAL OF IMMUNOLOGY

Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse

(2013) Javier A. Carrero et al.   PLoS One

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes

(2013) M. Pietropaolo et al.   Cold Spring Harbor Perspectives in Medicine

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

(2011) J. Chee et al.   JOURNAL OF IMMUNOLOGY

Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response

(2011) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans

(2011) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis

(2010) Vladislav Volarevic et al.   AUTOIMMUNITY

Isolated human islets contain a distinct population of mesenchymal stem cells

(2010) Françoise Carlotti et al.   Islets

KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine Receptors

(2009) Michael A. Weinreich et al.   IMMUNITY

Suppression of Autoimmune Diabetes by Soluble Galectin-1

(2009) M. J. Perone et al.   JOURNAL OF IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Insulin as an autoantigen in NOD/human diabetes

(2008) Li Zhang et al.   CURRENT OPINION IN IMMUNOLOGY