Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset

The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future

(2018) Yi-Guang Chen et al.   Frontiers in Endocrinology

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

(2018) Xiaoxiao Wan et al.   NATURE

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

(2018) Michelle So et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

(2017) Stephen T. Ferris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity

(2017) Henrike J. Fischer et al.   JOURNAL OF IMMUNOLOGY

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Singular role for T-BET+CXCR3+regulatory T cells in protection from autoimmune diabetes

(2016) Tze Guan Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection

(2015) Claudia X. Dominguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

(2015) Xinli Hu et al.   NATURE GENETICS

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes

(2014) Vimukthi Pathiraja et al.   DIABETES

Cross-Linking of CD80 on CD4+ T Cells Activates a Calcium-Dependent Signaling Pathway

(2014) J. R. Podojil et al.   JOURNAL OF IMMUNOLOGY

Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

(2013) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire

(2011) Menno van Lummel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

Assignment of PolyProline II Conformation and Analysis of Sequence – Structure Relationship

(2011) Yohann Mansiaux et al.   PLoS One

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

(2011) F. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ

(2010) G. Fousteri et al.   DIABETOLOGIA

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity

(2010) Kenji Yoshida et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

(2009) E. Landais et al.   JOURNAL OF IMMUNOLOGY

A protocol for islet isolation from mouse pancreas

(2009) Dong-Sheng Li et al.   Nature Protocols

Weak Proinsulin Peptide-Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

(2008) M. G. Levisetti et al.   DIABETES

The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease

(2008) Zaruhi Hovhannisyan et al.   NATURE