High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy

Treatment of a Mouse Model of ALS by In Vivo Base Editing

(2020) Colin K.W. Lim et al.   MOLECULAR THERAPY

A single “all-in-one” helper-dependent adenovirus to deliver donor DNA and CRISPR/Cas9 for efficient homology-directed repair

(2020) Donna J. Palmer et al.   Molecular Therapy-Methods & Clinical Development

Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial

(2020) Pedro M Folegatti et al.   LANCET INFECTIOUS DISEASES

TALEN-Mediated Gene Targeting for Cystic Fibrosis-Gene Therapy

(2019) Emily Xia et al.   Genes

Protein-Engineered Coagulation Factors for Hemophilia Gene Therapy

(2019) Benjamin J. Samelson-Jones et al.   Molecular Therapy-Methods & Clinical Development

CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems

(2019) Danila del Rio et al.   Frontiers in Molecular Neuroscience

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

(2019) Alexander T. Baker et al.   Nature Communications

Identification of preexisting adaptive immunity to Cas9 proteins in humans

(2019) Carsten T. Charlesworth et al.   NATURE MEDICINE

Adenine base editing in an adult mouse model of tyrosinaemia

(2019) Chun-Qing Song et al.   Nature Biomedical Engineering

Therapeutic developments for Duchenne muscular dystrophy

(2019) Ingrid E. C. Verhaart et al.   Nature Reviews Neurology

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

(2019) Barry J. Byrne et al.   Annals of Translational Medicine

Exploring the functions of polymers in adenovirus-mediated gene delivery: Evading immune response and redirecting tropism

(2019) Yanping Sun et al.   Acta Biomaterialia

Adenovirus persistence, reactivation, and clinical management

(2019) Thomas Lion   FEBS LETTERS

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

(2019) Gaia Colasante et al.   MOLECULAR THERAPY

Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors

(2019) Chang Li et al.   MOLECULAR THERAPY

No more helper adenovirus: production of gutless adenovirus (GLAd) free of adenovirus and replication-competent adenovirus (RCA) contaminants

(2019) Dongwoo Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Strategies for inducing effective neutralizing antibody responses against HIV-1

(2019) Iván del Moral-Sánchez et al.   Expert Review of Vaccines

Adenovirus vectors in hematopoietic stem cell genome editing

(2019) Chang Li et al.   FEBS LETTERS

A novel method to purify adenovirus based on increasing salt concentrations in buffer

(2019) Jinhu Ma et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses

(2019) Donna J. Palmer et al.   Molecular Therapy-Methods & Clinical Development

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

(2018) Chang Li et al.   BLOOD

Transducing Airway Basal Cells with a Helper-Dependent Adenoviral Vector for Lung Gene Therapy

(2018) Huibi Cao et al.   HUMAN GENE THERAPY

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

(2018) Frederick F. Lang et al.   JOURNAL OF CLINICAL ONCOLOGY

Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy

(2018) Suhail Khoja et al.   MOLECULAR GENETICS AND METABOLISM

Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum

(2018) Astrid Kritzinger et al.   NEUROBIOLOGY OF AGING

Development of novel vaccine vectors: Chimpanzee adenoviral vectors

(2018) Jingao Guo et al.   Human Vaccines & Immunotherapeutics

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors

(2018) Maren Schiwon et al.   Molecular Therapy-Nucleic Acids

HDAd5/35 ++ Adenovirus Vector Expressing Anti-CRISPR Peptides Decreases CRISPR/Cas9 Toxicity in Human Hematopoietic Stem Cells

(2018) Chang Li et al.   Molecular Therapy-Methods & Clinical Development

Designer Oncolytic Adenovirus: Coming of Age

(2018) Alexander Baker et al.   Cancers

ABCA1 overexpression in endothelial cells in vitro enhances apoAI-mediated cholesterol efflux and decreases inflammation

(2018) Alexis Stamatikos et al.   HUMAN GENE THERAPY

Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases

(2018) Inbal Zafir-Lavie et al.   JOURNAL OF CONTROLLED RELEASE

Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction

(2018) Emily Xia et al.   Molecular Therapy-Nucleic Acids

Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment

(2017) Joanna Poutou et al.   JOURNAL OF CONTROLLED RELEASE

TARGT Gene Therapy Platform for Correction of Anemia in End-Stage Renal Disease

(2017) Shany Blum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimpanzee Adenovirus Vector Ebola Vaccine

(2017) Julie E. Ledgerwood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models

(2017) Nicola Brunetti-Pierri et al.   VIRUS GENES

Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

(2017) Katie Ewer et al.   Human Vaccines & Immunotherapeutics

Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits

(2017) Bradley K. Wacker et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention

(2016) Lindsey R. Baden et al.   ANNALS OF INTERNAL MEDICINE

Emerging therapies for acute intermittent porphyria

(2016) Antonio Fontanellas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus

(2016) D P W Rastall et al.   GENE THERAPY

Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity

(2016) C. Zussy et al.   JOURNAL OF NEUROSCIENCE

Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial

(2016) Maria Sessa et al.   LANCET

Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations

(2016) Ignazio Maggio et al.   NUCLEIC ACIDS RESEARCH

Successful Phenotype Improvement following Gene Therapy for Severe Hemophilia A in Privately Owned Dogs

(2016) Mary Beth Callan et al.   PLoS One

Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn “On” Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model

(2016) Nathan VanderVeen et al.   Human Gene Therapy Methods

Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors

(2016) Donna J Palmer et al.   Molecular Therapy-Nucleic Acids

A High-Capacity Adenoviral Hybrid Vector System Utilizing the Hyperactive Sleeping Beauty Transposase SB100X for Enhanced Integration

(2016) Philip Boehme et al.   Molecular Therapy-Nucleic Acids

Glyco-engineering strategies for the development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage diseases

(2015) Doo-Byoung Oh   BMB Reports

Chromatographic purification of adenoviral vectors on anion-exchange resins

(2015) Huaben Bo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression

(2015) C Unzu et al.   GENE THERAPY

Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model

(2015) J Poutou et al.   GENE THERAPY

Helper-dependent adenoviral vectors for liver-directed gene therapy of primary hyperoxaluria type 1

(2015) R Castello et al.   GENE THERAPY

Robust design of adenovirus purification by two-column, simulated moving-bed, size-exclusion chromatography

(2015) Piergiuseppe Nestola et al.   JOURNAL OF BIOTECHNOLOGY

The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry

(2015) Fabien Loustalot et al.   JOURNAL OF VIROLOGY

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

(2015) Lindsay A. Schwarz et al.   NATURE

Oral Priming with Replicating Adenovirus Serotype 4 Followed by Subunit H5N1 Vaccine Boost Promotes Antibody Affinity Maturation and Expands H5N1 Cross-Clade Neutralization

(2015) Surender Khurana et al.   PLoS One

Preclinical and Preliminary Clinical Evaluation of Genetically Transduced Dermal Tissue Implants for the Sustained Secretion of Erythropoietin and Interferon α

(2015) Nir Shapir et al.   Human Gene Therapy Clinical Development

Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation

(2015) Kamola Saydaminova et al.   Molecular Therapy-Methods & Clinical Development

Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector

(2014) K Oka et al.   GENE THERAPY

Adenovirus: The First Effective In Vivo Gene Delivery Vector

(2014) Ronald G. Crystal   HUMAN GENE THERAPY

Characterization of Pulmonary T Cell Response to Helper-Dependent Adenoviral Vectors following Intranasal Delivery

(2014) R. Kushwah et al.   JOURNAL OF IMMUNOLOGY

Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver

(2014) Pilar Alzuguren et al.   LIVER INTERNATIONAL

Promoterless gene targeting without nucleases ameliorates haemophilia B in mice

(2014) A. Barzel et al.   NATURE

Adenoviral vector DNA for accurate genome editing with engineered nucleases

(2014) Maarten Holkers et al.   NATURE METHODS

Fiber-Modified Adenovirus for Central Nervous System Parkinson’s Disease Gene Therapy

(2014) Travis Lewis et al.   Viruses-Basel

Coat as a Dagger: The Use of Capsid Proteins to Perforate Membranes during Non-Enveloped DNA Viruses Trafficking

(2014) Eva Bilkova et al.   Viruses-Basel

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

(2013) J. McIntosh et al.   BLOOD

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Coxsackievirus and adenovirus receptor-positive cells compose the putative stem/progenitor cell niches in the marginal cell layer and parenchyma of the rat anterior pituitary

(2013) Mo Chen et al.   CELL AND TISSUE RESEARCH

In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV

(2013) P S Montenegro-Miranda et al.   GENE THERAPY

PEGylated helper-dependent adenoviral vector expressing human Apo A-I for gene therapy in LDLR-deficient mice

(2013) E Leggiero et al.   GENE THERAPY

Transgene Expression up to 7 Years in Nonhuman Primates Following Hepatic Transduction with Helper-Dependent Adenoviral Vectors

(2013) Nicola Brunetti-Pierri et al.   HUMAN GENE THERAPY

Central Nervous System Delivery of Helper-Dependent Canine Adenovirus Corrects Neuropathology and Behavior in Mucopolysaccharidosis Type VII Mice

(2013) Lorena Ariza et al.   HUMAN GENE THERAPY

Helper-dependent adenoviral liver gene therapy protects against induced attacks and corrects protein folding stress in acute intermittent porphyria mice

(2013) Carmen Unzu et al.   HUMAN MOLECULAR GENETICS

Disruption of the Coxsackievirus and Adenovirus Receptor-Homodimeric Interaction Triggers Lipid Microdomain- and Dynamin-dependent Endocytosis and Lysosomal Targeting

(2013) Sara Salinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seroprevalence of neutralizing antibodies to human adenoviruses type-5 and type-26 and chimpanzee adenovirus type-68 in healthy Chinese adults

(2013) Shujun Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Circulating Antibodies and Macrophages as Modulators of Adenovirus Pharmacology

(2013) R. Khare et al.   JOURNAL OF VIROLOGY

Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study

(2013) Marc Gurwith et al.   LANCET INFECTIOUS DISEASES

SR-A and SREC-I Are Kupffer and Endothelial Cell Receptors for Helper-dependent Adenoviral Vectors

(2013) Pasquale Piccolo et al.   MOLECULAR THERAPY

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

(2013) Zhili Xu et al.   NATURE MEDICINE

Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

(2013) Di Yu et al.   PLoS One

Differentiated Neuroprogenitor Cells Incubated with Human or Canine Adenovirus, or Lentiviral Vectors Have Distinct Transcriptome Profiles

(2013) Stefania Piersanti et al.   PLoS One

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

(2013) Wenli Zhang et al.   PLoS One

The Role of Chromatin in Adenoviral Vector Function

(2013) Carmen Wong et al.   Viruses-Basel

Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral Vectors

(2013) Huibi Cao et al.   Molecular Therapy-Nucleic Acids

DREADDing the lateral habenula: A review of methodological approaches for studying lateral habenula function

(2012) Sunila G. Nair et al.   BRAIN RESEARCH

Capsid-Modified Adenoviral Vectors for Improved Muscle-Directed Gene Therapy

(2012) Kilian Guse et al.   HUMAN GENE THERAPY

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration

(2012) Xiaomin Dong et al.   JOURNAL OF GENE MEDICINE

Balloon Catheter Delivery of Helper-dependent Adenoviral Vector Results in Sustained, Therapeutic hFIX Expression in Rhesus Macaques

(2012) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY

Adenovirus receptors: implications for targeting of viral vectors

(2012) Niklas Arnberg   TRENDS IN PHARMACOLOGICAL SCIENCES

Latest Insights on Adenovirus Structure and Assembly

(2012) Carmen San Martín   Viruses-Basel

Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal Brain Parenchyma: Implications for a Glioma Phase 1 Clinical Trial

(2012) A.K.M. Ghulam Muhammad et al.   Human Gene Therapy Methods

Kinesin-1-Mediated Capsid Disassembly and Disruption of the Nuclear Pore Complex Promote Virus Infection

(2011) Sten Strunze et al.   Cell Host & Microbe

Drifting Motions of the Adenovirus Receptor CAR and Immobile Integrins Initiate Virus Uncoating and Membrane Lytic Protein Exposure

(2011) Christoph J. Burckhardt et al.   Cell Host & Microbe

Self-inactivating helper virus for the production of high-capacity adenoviral vectors

(2011) M Gonzalez-Aparicio et al.   GENE THERAPY

NOD2 Signaling Contributes to the Innate Immune Response Against Helper-Dependent Adenovirus Vectors Independently of MyD88 In Vivo

(2011) Masataka Suzuki et al.   HUMAN GENE THERAPY

ΔE1 and high-capacity adenoviral vectors expressing full-length codon-optimized merozoite surface protein 1 for vaccination against Plasmodium falciparum

(2011) Shan Zong et al.   JOURNAL OF GENE MEDICINE

High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses

(2011) Matthias W. Kron et al.   JOURNAL OF GENE MEDICINE

Assembly of Helper-Dependent Adenovirus DNA into Chromatin Promotes Efficient Gene Expression

(2011) P. J. Ross et al.   JOURNAL OF VIROLOGY

Functional Genetic and Biophysical Analyses of Membrane Disruption by Human Adenovirus

(2011) C. L. Moyer et al.   JOURNAL OF VIROLOGY

Rescue From Respiratory Dysfunction by Transduction of Full-length Dystrophin to Diaphragm via the Peritoneal Cavity in Utrophin/Dystrophin Double Knockout Mice

(2011) Masatoshi Ishizaki et al.   MOLECULAR THERAPY

Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer

(2011) Reeti Khare et al.   MOLECULAR THERAPY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII

(2011) Chuhong Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma

(2010) A K M G Muhammad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Adenovirus: a blueprint for non-viral gene delivery

(2010) V Ann Chailertvanitkul et al.   CURRENT OPINION IN BIOTECHNOLOGY

Delivery of an EBV episome by a self-circularizing helper-dependent adenovirus: long-term transgene expression in immunocompetent mice

(2010) J S Gil et al.   GENE THERAPY

Evaluation of cross-reactive cell-mediated immune responses among human, bovine and porcine adenoviruses

(2010) A Sharma et al.   GENE THERAPY

Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice

(2010) M. Gonzalez-Aparicio et al.   GUT

An efficient process for the purification of helper-dependent adenoviral vector and removal of helper virus by iodixanol ultracentrifugation

(2010) Edwige Dormond et al.   JOURNAL OF VIROLOGICAL METHODS

A Novel Bicistronic High-Capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-Inducible Expression of Flt3L for Glioma Therapeutics

(2010) M. Puntel et al.   JOURNAL OF VIROLOGY

Species Differences in the Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus

(2010) Piyanuch Wonganan et al.   MOLECULAR PHARMACEUTICS

Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

(2010) Jan-Michael Prill et al.   MOLECULAR THERAPY

Genomic integration of adenoviral gene transfer vectors following transduction of fertilized mouse oocytes

(2010) Nancy Larochelle et al.   TRANSGENIC RESEARCH

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive

(2010) Natalie A. Hutnick et al.   VACCINE

Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys

(2010) Jonatan Ersching et al.   VIROLOGY

Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine

(2010) Glenda Gray et al.   Current Opinion in HIV and AIDS

HPMA copolymers for masking and retargeting of therapeutic viruses☆

(2009) Kerry D. Fisher et al.   ADVANCED DRUG DELIVERY REVIEWS

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

(2009) R. C. Carlisle et al.   BLOOD

Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1α

(2009) K Küster et al.   CANCER GENE THERAPY

Cetuximab Retargeting of Adenovirus via the Epidermal Growth Factor Receptor for Treatment of Intraperitoneal Ovarian Cancer

(2009) Joanne Morrison et al.   HUMAN GENE THERAPY

Persistence of High-Capacity Adenoviral Vectors as Replication-Defective Monomeric Genomes In Vitro and in Murine Liver

(2009) Lorenz Jager et al.   HUMAN GENE THERAPY

MyD88-Dependent Silencing of Transgene Expression During the Innate and Adaptive Immune Response to Helper-Dependent Adenovirus

(2009) Masataka Suzuki et al.   HUMAN GENE THERAPY

DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice

(2009) Tomoya Terashima et al.   JOURNAL OF CLINICAL INVESTIGATION

Host Cell Detection of Noncoding Stuffer DNA Contained in Helper-Dependent Adenovirus Vectors Leads to Epigenetic Repression of Transgene Expression

(2009) P. J. Ross et al.   JOURNAL OF VIROLOGY

Comparison of Replication-Competent, First Generation, and Helper-Dependent Adenoviral Vaccines

(2009) Eric A. Weaver et al.   PLoS One

Transplantation Procedures in Children With Primary Hyperoxaluria Type 1: Outcome and Longitudinal Growth

(2009) Florian Brinkert et al.   TRANSPLANTATION

CAR-Associated Vesicular Transport of an Adenovirus in Motor Neuron Axons

(2009) Sara Salinas et al.   PLoS Pathogens

Improved purification of recombinant adenoviral vector by metal affinity membrane chromatography

(2008) Dong-Sop Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards purification of adenoviral vectors based on membrane technology

(2008) Cristina Peixoto et al.   BIOTECHNOLOGY PROGRESS

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Treatment of Chronic Viral Hepatitis in Woodchucks by Prolonged Intrahepatic Expression of Interleukin-12

(2008) J. Crettaz et al.   JOURNAL OF VIROLOGY

High-Capacity Adenovirus Vector-Mediated Anti-Glioma Gene Therapy in the Presence of Systemic Antiadenovirus Immunity

(2008) G. D. King et al.   JOURNAL OF VIROLOGY

In Vitro and In Vivo Properties of Adenovirus Vectors with Increased Affinity to CD46

(2008) H. Wang et al.   JOURNAL OF VIROLOGY

Immunization Against the Transgene but not the TetON Switch Reduces Expression From Gutless Adenoviral Vectors in the Brain

(2008) Weidong Xiong et al.   MOLECULAR THERAPY

Transduction of Full-length Dystrophin to Multiple Skeletal Muscles Improves Motor Performance and Life Span in Utrophin/Dystrophin Double Knockout Mice

(2008) Ryoko Kawano et al.   MOLECULAR THERAPY

Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates

(2008) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

(2008) Irene Kuhn et al.   PLoS One

The astrocyte odyssey

(2008) D WANG et al.   PROGRESS IN NEUROBIOLOGY