Adenovirus vectors in hematopoietic stem cell genome editing

Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia

(2019) Sarah Marktel et al.   NATURE MEDICINE

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

(2019) Agnieszka Czechowicz et al.   Nature Communications

Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing

(2019) Baisong Lu et al.   NUCLEIC ACIDS RESEARCH

Highly efficient therapeutic gene editing of human hematopoietic stem cells

(2019) Yuxuan Wu et al.   NATURE MEDICINE

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

Gene Therapy for Beta-Hemoglobinopathies: Milestones, New Therapies and Challenges

(2019) Valentina Ghiaccio et al.   Molecular Diagnosis & Therapy

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9

(2019) Calvin J. Stephens et al.   JOURNAL OF CONTROLLED RELEASE

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination

(2019) Renata M. Martin et al.   Cell Stem Cell

Editing the Sickle Cell Disease Mutation in Primary Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates

(2019) Zulema Romero et al.   MOLECULAR THERAPY

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

(2019) Julian Grünewald et al.   NATURE

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

(2019) Tony P. Huang et al.   NATURE BIOTECHNOLOGY

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clinical advances in gene therapy updates on clinical trials of gene therapy in haemophilia

(2019) Flora Peyvandi et al.   HAEMOPHILIA

Gene Therapy

(2019) Katherine A. High et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease

(2019) So Hyun Park et al.   NUCLEIC ACIDS RESEARCH

Direct delivery of adenoviral CRISPR/Cas9 vector into the blastoderm for generation of targeted gene knockout in quail

(2019) Joonbum Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses

(2019) Donna J. Palmer et al.   Molecular Therapy-Methods & Clinical Development

Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors

(2019) Chang Li et al.   MOLECULAR THERAPY

CRISPR DNA base editors with reduced RNA off-target and self-editing activities

(2019) Julian Grünewald et al.   NATURE BIOTECHNOLOGY

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia

(2019) Paula Río et al.   NATURE MEDICINE

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

(2019) Lei Xu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells

(2019) Tomohito Tsukamoto et al.   JOURNAL OF BIOTECHNOLOGY

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

(2018) Chang Li et al.   BLOOD

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

(2018) Nan Liu et al.   CELL

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3

(2018) Alexandra C. Chadwick et al.   CIRCULATION

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

(2018) Luke W Koblan et al.   NATURE BIOTECHNOLOGY

Optimized base editors enable efficient editing in cells, organoids and mice

(2018) Maria Paz Zafra et al.   NATURE BIOTECHNOLOGY

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

(2018) Gabriella E. Martyn et al.   NATURE GENETICS

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

(2018) Robert J. Ihry et al.   NATURE MEDICINE

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

(2018) Alexis A. Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures

(2018) Youdiil Ophinni et al.   Scientific Reports

Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice

(2018) Ramona Bella et al.   Molecular Therapy-Nucleic Acids

HDAd5/35 ++ Adenovirus Vector Expressing Anti-CRISPR Peptides Decreases CRISPR/Cas9 Toxicity in Human Hematopoietic Stem Cells

(2018) Chang Li et al.   Molecular Therapy-Methods & Clinical Development

Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies

(2018) Chang Li et al.   Molecular Therapy-Methods & Clinical Development

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

(2018) Hongjie Wang et al.   Molecular Therapy-Methods & Clinical Development

Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus

(2018) Ashley L Cooney et al.   NUCLEIC ACIDS RESEARCH

CRISPR-Cas guides the future of genetic engineering

(2018) Gavin J. Knott et al.   SCIENCE

Emerging Genetic Therapy for Sickle Cell Disease

(2018) Stuart H. Orkin et al.   Annual Review of Medicine

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia

(2018) Hongjie Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Base editing: precision chemistry on the genome and transcriptome of living cells

(2018) Holly A. Rees et al.   NATURE REVIEWS GENETICS

Viral vector-based delivery of CRISPR/Cas9 and donor DNA for homology directed repair in an in vitro model for canine hemophilia B

(2018) Jian Gao et al.   Molecular Therapy-Nucleic Acids

In Vivo Hematopoietic Stem Cell Transduction

(2017) Maximilian Richter et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Transposons: Moving Forward from Preclinical Studies to Clinical Trials

(2017) Jaitip Tipanee et al.   HUMAN GENE THERAPY

Oncolytic Virotherapy: A Contest between Apples and Oranges

(2017) Stephen J. Russell et al.   MOLECULAR THERAPY

Gene Therapy for β-Hemoglobinopathies

(2017) Marina Cavazzana et al.   MOLECULAR THERAPY

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations

(2017) Cem Kuscu et al.   NATURE METHODS

Anti-CRISPR: discovery, mechanism and function

(2017) April Pawluk et al.   NATURE REVIEWS MICROBIOLOGY

Gene Therapy in a Patient with Sickle Cell Disease

(2017) Jean-Antoine Ribeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

(2017) Sachith Mettananda et al.   Nature Communications

Highly efficient gene inactivation by adenoviral CRISPR/Cas9 in human primary cells

(2017) Olaf Voets et al.   PLoS One

CRISPR/Cas9 delivery with one single adenoviral vector devoid of all viral genes

(2017) Eric Ehrke-Schulz et al.   Scientific Reports

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

(2016) M. Richter et al.   BLOOD

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

(2016) Angelo Amabile et al.   CELL

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

(2016) Partow Kebriaei et al.   JOURNAL OF CLINICAL INVESTIGATION

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

(2016) Daniel P. Dever et al.   NATURE

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease

(2016) Suk See De Ravin et al.   NATURE BIOTECHNOLOGY

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

(2016) Bernd Zetsche et al.   NATURE BIOTECHNOLOGY

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

(2016) Elizabeth A Traxler et al.   NATURE MEDICINE

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

(2016) K. Nishida et al.   SCIENCE

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

(2016) Raman Bahal et al.   Nature Communications

Development of Lentiviral Vectors Simultaneously Expressing Multiple siRNAs Against CCR5, vif and tat/rev Genes for an HIV-1 Gene Therapy Approach

(2016) Francesca Spanevello et al.   Molecular Therapy-Nucleic Acids

Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A

(2016) Allison M Lytle et al.   Molecular Therapy-Methods & Clinical Development

Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic

(2016) Maximilian Richter et al.   Molecular Therapy-Methods & Clinical Development

Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9

(2015) Chang Li et al.   JOURNAL OF GENERAL VIROLOGY

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

(2015) Matthew C. Canver et al.   NATURE

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses

(2015) Martin Mück-Häusl et al.   NUCLEIC ACIDS RESEARCH

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template

(2015) Blythe D. Sather et al.   Science Translational Medicine

Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation

(2015) Kamola Saydaminova et al.   Molecular Therapy-Methods & Clinical Development

Safe mobilization of CD34+ cells in adults with  -thalassemia and validation of effective globin gene transfer for clinical investigation

(2014) F. Boulad et al.   BLOOD

Intravenous injection of a foamy virus vector to correct canine SCID-X1

(2014) C. R. Burtner et al.   BLOOD

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

(2014) C. X. Wang et al.   BLOOD

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

(2014) Wulan Deng et al.   CELL

Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones

(2014) Keiichiro Suzuki et al.   Cell Stem Cell

Adenoviruses as gene/vaccine delivery vectors: promises and pitfalls

(2014) Mohan Babu Appaiahgari et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Adenovirus: The First Effective In Vivo Gene Delivery Vector

(2014) Ronald G. Crystal   HUMAN GENE THERAPY

Construction and characterization of adenoviral vectors for the delivery of TALENs into human cells

(2014) Maarten Holkers et al.   METHODS

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation

(2014) Lambros Kordelas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

(2014) Steven Lin et al.   eLife

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

(2014) Kahori Shimizu et al.   Molecular Therapy-Methods & Clinical Development

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

(2014) Harrison C Brown et al.   Molecular Therapy-Methods & Clinical Development

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

(2013) C. A. Didigu et al.   BLOOD

Why does the bone marrow fail in Fanconi anemia?

(2013) J. I. Garaycoechea et al.   BLOOD

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

(2013) Albert W Cheng et al.   CELL RESEARCH

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases

(2013) Lijing Li et al.   MOLECULAR THERAPY

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

(2013) Sandrine Boissel et al.   NUCLEIC ACIDS RESEARCH

High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression by Optimized AAV6 Serotype Vectors In Vitro and in a Murine Xenograft Model In Vivo

(2013) Liujiang Song et al.   PLoS One

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

(2013) Wenli Zhang et al.   PLoS One

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

(2013) B. Wefers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Development of hybrid viral vectors for gene therapy

(2012) Shuohao Huang et al.   BIOTECHNOLOGY ADVANCES

In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration

(2012) Sandra Cristea et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engraftment defect of cytokine-cultured adult human mobilized CD34+ cells is related to reduced adhesion to bone marrow niche elements

(2012) Konstantina Kallinikou et al.   BRITISH JOURNAL OF HAEMATOLOGY

Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells

(2012) R van Rensburg et al.   GENE THERAPY

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

(2012) J. Wang et al.   GENOME RESEARCH

Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob protein

(2012) W. C. Adams et al.   JOURNAL OF GENERAL VIROLOGY

Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity

(2012) M. J. Johnson et al.   JOURNAL OF IMMUNOLOGY

Safer, Silencing-Resistant Lentiviral Vectors: Optimization of the Ubiquitous Chromatin-Opening Element through Elimination of Aberrant Splicing

(2012) S. Knight et al.   JOURNAL OF VIROLOGY

A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses

(2012) H. Wang et al.   JOURNAL OF VIROLOGY

Balloon Catheter Delivery of Helper-dependent Adenoviral Vector Results in Sustained, Therapeutic hFIX Expression in Rhesus Macaques

(2012) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY

Transient Removal of CD46 Is Safe and Increases B-cell Depletion by Rituximab in CD46 Transgenic Mice and Macaques

(2012) Ines Beyer et al.   MOLECULAR THERAPY

Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters

(2012) Masaki Shoji et al.   PLoS One

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

(2012) K. Doronin et al.   SCIENCE

The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

(2012) A. N.-S. Mak et al.   SCIENCE

A Novel Hybrid Adenoretroviral Vector with More Extensive E3 Deletion Extends Transgene Expression in Submandibular Glands

(2012) Changyu Zheng et al.   Human Gene Therapy Methods

Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

(2011) Mo Li et al.   CELL RESEARCH

New insights into stability of recombinant adenovirus vector genomes in mammalian cells

(2011) Christina Rauschhuber et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer

(2011) Reeti Khare et al.   MOLECULAR THERAPY

Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII

(2011) Chuhong Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation

(2011) W. C. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

(2011) Dan H. Barouch et al.   VACCINE

Delivery of an EBV episome by a self-circularizing helper-dependent adenovirus: long-term transgene expression in immunocompetent mice

(2010) J S Gil et al.   GENE THERAPY

Targeted Genome Modification in Mice Using Zinc-Finger Nucleases

(2010) I. D. Carbery et al.   GENETICS

Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates

(2010) Brian C. Beard et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B

(2010) Martin A Hausl et al.   MOLECULAR THERAPY

Adenovirus–Retrovirus Hybrid Vectors Achieve Highly Enhanced Tumor Transduction and Antitumor Efficacy In Vivo

(2010) Shuji Kubo et al.   MOLECULAR THERAPY

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

(2010) Eirini P Papapetrou et al.   NATURE BIOTECHNOLOGY

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

(2009) A. Perumbeti et al.   BLOOD

Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells

(2009) Jizhong Zou et al.   Cell Stem Cell

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency

(2009) James M. Wilson   MOLECULAR GENETICS AND METABOLISM

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

(2009) Alessandro Aiuti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc-/- stem cells

(2008) Y. Si et al.   BLOOD

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Episomal Vectors for Gene Therapy

(2008) Anja Ehrhardt et al.   CURRENT GENE THERAPY

Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors

(2008) N Brunetti-Pierri et al.   GENE THERAPY

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Homologous and heterologous recombination between adenovirus vector DNA and chromosomal DNA

(2008) Sam Laurel Stephen et al.   JOURNAL OF GENE MEDICINE

In Vitro and In Vivo Properties of Adenovirus Vectors with Increased Affinity to CD46

(2008) H. Wang et al.   JOURNAL OF VIROLOGY

Transduction Properties of Adenovirus Serotype 35 Vectors After Intravenous Administration Into Nonhuman Primates

(2008) Fuminori Sakurai et al.   MOLECULAR THERAPY

Extended Transgene Expression From a Nonintegrating Adenoviral Vector Containing Retroviral Elements

(2008) Changyu Zheng et al.   MOLECULAR THERAPY

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors

(2008) K. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE