Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models

Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus

(2016) D P W Rastall et al.   GENE THERAPY

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression

(2015) C Unzu et al.   GENE THERAPY

Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector

(2014) K Oka et al.   GENE THERAPY

PEGylated helper-dependent adenoviral vector expressing human Apo A-I for gene therapy in LDLR-deficient mice

(2013) E Leggiero et al.   GENE THERAPY

Transgene Expression up to 7 Years in Nonhuman Primates Following Hepatic Transduction with Helper-Dependent Adenoviral Vectors

(2013) Nicola Brunetti-Pierri et al.   HUMAN GENE THERAPY

Prime/Boost Immunization with DNA and Adenoviral Vectors Protects from Hepatitis D Virus (HDV) Infection after Simultaneous Infection with HDV and Woodchuck Hepatitis Virus

(2013) M. Fiedler et al.   JOURNAL OF VIROLOGY

The Role of Chromatin in Adenoviral Vector Function

(2013) Carmen Wong et al.   Viruses-Basel

Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral Vectors

(2013) Huibi Cao et al.   Molecular Therapy-Nucleic Acids

Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B

(2012) Itziar Otano et al.   HEPATOLOGY

Balloon Catheter Delivery of Helper-dependent Adenoviral Vector Results in Sustained, Therapeutic hFIX Expression in Rhesus Macaques

(2012) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY

Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia

(2011) B Crane et al.   GENE THERAPY

Assembly of Helper-Dependent Adenovirus DNA into Chromatin Promotes Efficient Gene Expression

(2011) P. J. Ross et al.   JOURNAL OF VIROLOGY

Identification of Adenovirus Serotype 5 Hexon Regions That Interact with Scavenger Receptors

(2011) R. Khare et al.   JOURNAL OF VIROLOGY

Species Differences in the Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus

(2010) Piyanuch Wonganan et al.   MOLECULAR PHARMACEUTICS

Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B

(2010) Martin A Hausl et al.   MOLECULAR THERAPY

Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

(2010) Jan-Michael Prill et al.   MOLECULAR THERAPY

Persistence of High-Capacity Adenoviral Vectors as Replication-Defective Monomeric Genomes In Vitro and in Murine Liver

(2009) Lorenz Jager et al.   HUMAN GENE THERAPY

Host Cell Detection of Noncoding Stuffer DNA Contained in Helper-Dependent Adenovirus Vectors Leads to Epigenetic Repression of Transgene Expression

(2009) P. J. Ross et al.   JOURNAL OF VIROLOGY

Comparison of Replication-Competent, First Generation, and Helper-Dependent Adenoviral Vaccines

(2009) Eric A. Weaver et al.   PLoS One

Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines

(2009) Eric Weaver et al.   Viruses-Basel

Treatment of Chronic Viral Hepatitis in Woodchucks by Prolonged Intrahepatic Expression of Interleukin-12

(2008) J. Crettaz et al.   JOURNAL OF VIROLOGY

Modification of Adenoviral Vectors With Polyethylene Glycol Modulates In Vivo Tissue Tropism and Gene Expression

(2008) Sean E Hofherr et al.   MOLECULAR THERAPY

Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates

(2008) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY